AptaDB: Result

Interaction ID: 1139

Aptamer sequence: TGGGGTGGTGGTGTGGGTGGGGGTTTGTTC

Target unique ID: P09758

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_1085	Tac-B3	Protein	TACD2_HUMAN	187 nM	1 mM MgCl2 in PBS Buffer, Binding-20 mM Tris-HCl buffer [pH 7.4], 10 mM NaCl, 1 mM MgCl2, and 0.05% Tween 20	34204006

Aptamer Sequence:	TGGGGTGGTGGTGTGGGTGGGGGTTTGTTC
The optimal secondary structure in dot-bracket notation:	..............................
The centroid secondary structure in dot-bracket notation:	..............................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_1085	Description	Tac-B3
Aptamer chemistry	DNA	Length	30 nt
GC content	63.3%	Molecular weight	9,499.05 Da
Molarity of 1 μg/μl solution	105.27 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	TGGGGTGGTGGTGTGGGTGGGGGTTTGTTC
Applications	Capacity for internalization by cells

Type	Detail	Type	Detail
Uniprot ID	P09758	Protein name	Tumor-associated calcium signal transducer 2 (Cell surface glycoprotein Trop-2) (Membrane component chromosome 1 surface marker 1) (Pancreatic carcinoma marker protein GA733-1)
Gene name(s)	TACSTD2 GA733-1 M1S1 TROP2	Organism	Tumor-associated calcium signal transducer 2 (Cell surface glycoprotein Trop-2) (Membrane component chromosome 1 surface marker 1) (Pancreatic carcinoma marker protein GA733-1)
Status	reviewed in uniprot database	Length	323
Mass	35,709	Activity regulation	N/A
Involvement in disease	Corneal dystrophy, gelatinous drop-like (GDLD)	Catalytic activity	N/A
PDB ID(s)	2MAE;2MVK;2MVL;7E5M;7E5N;7PEE;
Function	May function as a growth factor receptor.

	Interaction ID	1139
	Target type	Protein
	Target unique ID	P09758
	Activity	187 nM
	Binding Conditions/Buffer	1 mM MgCl2 in PBS Buffer, Binding-20 mM Tris-HCl buffer [pH 7.4], 10 mM NaCl, 1 mM MgCl2, and 0.05% Tween 20
	Assay	Evaluation of the internalization of each aptamer obtained via CE-SELEX and hybrid-type SELEX
	PubMed ID	34204006

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_25	DNA	TGTGGGGGTGGTTGGGCGGGGCTGC	70.00%
Apta_1241	DNA	GGTGTGGAGTGGTGTGTGTTGTTGTTTGTC	70.00%
Apta_12	DNA	TGAGGGGGTGGGTGGGACGGGTTGG	66.67%
Apta_124	DNA	GGTGGTGGGGGGGGTTGGTAGGGTGTCTTC	66.67%
Apta_350	DNA	GGTGGTGGTGGTTGTGGTGGTGGTGG	66.67%
Apta_1245	DNA	AGTGTGAAGTGGTGTGTGTTGTTGTTTGTC	66.67%
Apta_69	DNA	AGCGAGTAGGTTGGTGTGGTTGGGGCTCGCT	64.52%
Apta_71	DNA	GGCGAGTAGGTTGGTGTGGTTGGGGCTCGCC	64.52%
Apta_73	DNA	GGGGAGTAGGTTGGTGTGGTTGGGGCTCCCC	64.52%
Apta_74	DNA	GGACAGTAGGTTGGTGTGGTTGGGGCTGTCC	64.52%
Apta_10	DNA	GGGGGGGGTGGCTGGGCGGGGTGGG	63.33%
Apta_13	DNA	AGGGGGGGGGGAGGGGTCGGGGTGG	63.33%
Apta_15	DNA	TGAGGGGGGGGGAGGGCGGGGCTGC	63.33%
Apta_17	DNA	AGGGGGGGGGGTGGGGGTGGGTCCC	63.33%
Apta_18	DNA	TGGGGGGTTGGACGGGCGGGGCTGC	63.33%
Apta_20	DNA	AGAGGGGGGGGTGGGGGTGGCCTGC	63.33%
Apta_22	DNA	TGTGGGGGTGGACTGGGTGGGTACC	63.33%
Apta_757	DNA	GGTGGTGGTGGTTGTGGTGGTGG	63.33%
Apta_1193	DNA	GGGTTGGAGGTGGAGGGGAGTTGAGG	63.33%
Apta_266	DNA	TGGATGGTAGCTCGGTCGGGGTGGGTGGGTTGGCAAGTCT	62.50%

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