AptaDB: Result

Interaction ID: 1133

Aptamer sequence: GGGCGCUCAAUUUUUUAUUGCAUUUUUCUUUGAGCGCCC

Target unique ID: P60170

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_1079	39SGP1A	Protein	VSGP_EBOZM	27 nM	137 mM NaCl, 2.7 mM KCl, 10 mM Na2HPO4, 2 mM KH2PO4, 5 mM MgCl2, pH 7.4	30120364

Aptamer Sequence:	GGGCGCUCAAUUUUUUAUUGCAUUUUUCUUUGAGCGCCC
The optimal secondary structure in dot-bracket notation:	((((((((((...................))))))))))
The centroid secondary structure in dot-bracket notation:	((((((((((...................))))))))))

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_1079	Description	39SGP1A
Aptamer chemistry	RNA	Length	39 nt
GC content	43.6%	Molecular weight	12,297.16 Da
Molarity of 1 μg/μl solution	81.32 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Aptasensor
Sequence	GGGCGCUCAAUUUUUUAUUGCAUUUUUCUUUGAGCGCCC
Applications	Detection ebolavirus infections

Type	Detail	Type	Detail
Uniprot ID	P60170	Protein name	Pre-small/secreted glycoprotein (pre-sGP) [Cleaved into: Small/secreted glycoprotein (sGP); Delta-peptide]
Gene name(s)	GP	Organism	Pre-small/secreted glycoprotein (pre-sGP) [Cleaved into: Small/secreted glycoprotein (sGP); Delta-peptide]
Status	reviewed in uniprot database	Length	364
Mass	41,175	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	N/A
Function	sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.

	Interaction ID	1133
	Target type	Protein
	Target unique ID	P60170
	Activity	27 nM
	Binding Conditions/Buffer	137 mM NaCl, 2.7 mM KCl, 10 mM Na2HPO4, 2 mM KH2PO4, 5 mM MgCl2, pH 7.4
	Assay	Specifcity of Oligonucleotides 5183 and 39SGP1A for EBOV sGP
	PubMed ID	30120364

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_289	RNA	GGGGGCUUAUCAUUCCAUUUAGUGUUAUGAUAACC	56.41%
Apta_367	RNA	CGAGCGUAGAAUGUCUUCCCACUAGACGUCGUUCGGCCCC	50.00%
Apta_603	RNA	CUUGUCUGAACAAUUUCGUCUGCCUUUGCGUUCCGACGGC	50.00%
Apta_1249	RNA	AAUCGGCCCAAUUUUACCUUCGGACUUCAGUAUCUAGUGUGGCUUUAAAUCAUAGC	50.00%
Apta_129	RNA	GGGAGGACGAUGCGGACACCGUUAAUCUGAGGCCCUGUCCUAUUCCUUCACGCCUCAGA	49.15%
Apta_131	RNA	GGGAGGACGAUGCGGUCCUGUCGUCUGUUCGUCCCCAGACGACUCGCCCGA	49.02%
Apta_859	RNA	GGGAGUCUGAAGUCGGACUUGUUAUCAAUUCACUUCAGACU	48.78%
Apta_1141	RNA	ACGAGUCUGGUCCUUCCUUUGACGACUAUUGUUUGGUAUCGAUCAACAACAA	48.08%
Apta_304	RNA	CGGCCGAUAGAAAGACUACUUGAGCCCUUAAAUGAGGUUAUGUGCGGCCG	48.00%
Apta_703	RNA	GGGCGGAUGAGACGCUUGGCGUGUGCUGUGGAGAGUCAUCCG	47.62%
Apta_521	RNA	GGGUUGGGAAGAAACUGUGGCACUUCGGUGCCAGCAACCC	47.50%
Apta_132	RNA	GGGAGGACGAUGCGGCGUUUCCUCUGGUUCGUCCCCAGACGACUCGCCCGA	47.06%
Apta_133	RNA	GGGAGGACGAUGCGGUGAGUCGUUCCCUUCGUCCCCAGACGACUCGCCCGA	47.06%
Apta_135	RNA	GGGAGGACGAUGCGGAUUCUGGUUACUGGCCGCCCCAGACGACUCGCCCGA	47.06%
Apta_394	RNA	GGGCGAAUUCAACUGCCAUCUAGGCAGUAACCAGGAGUUAGUAGGACAAGUUUCGUCC	46.55%
Apta_984	RNA	GGGAGGACGAUGCGGCGUAUUGCGCGAGGAUUAUCCGCUCAUCGUUGUUGUUGUGCAGACGACUCGCCCGA	46.48%
Apta_460	RNA	GGAUGGCAGCGGAGAGUUGCUUGGAAUGCGUUAUAGUCUCUUAGGUGUGUACAGCCCACACCACUCUCC	46.38%
Apta_230	RNA	GGGAGGACGAUGCGGGCGUGAAUGGUGUUGUGAGG	46.15%
Apta_634	RNA	GGUCUUACGUCGUUCGCGACUAUUGGGAGACC	46.15%
Apta_716	RNA	GGCGCUUCAUGCCGAAAGGCCCGUUGUAACGUC	46.15%

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