Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1141
Aptamer sequence: CTTACGACTCAGGCATTTTGCCGGGTAACGAAGTTACTGTCGTAAG
Target unique ID: 20111961
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_1087 MA Molecule Methylenedioxypyrovalerone 6.1 μM 10 mM Tris-HCl, 0.5 mM MgCl2, 20 mM NaCl, pH 7.4 29361056
Structure information of aptamer
Aptamer Sequence: CTTACGACTCAGGCATTTTGCCGGGTAACGAAGTTACTGTCGTAAG
The optimal secondary structure in dot-bracket notation: ((((((((...((((...)))).((((((...))))))))))))))
The centroid secondary structure in dot-bracket notation: ((((((((...((((...)))).((((((...))))))))))))))
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_1087 Description MA
Aptamer chemistry DNA Length 46 nt
GC content 47.8% Molecular weight 14,180.11 Da
Molarity of 1 μg/μl solution 70.52 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Aptasensor
Sequence CTTACGACTCAGGCATTTTGCCGGGTAACGAAGTTACTGTCGTAAG
Applications Detection of MDPV
Target information
Type Detail Type Detail
PubChem ID 20111961 Molecular name Methylenedioxypyrovalerone
Molecular formula C16H21NO3 Molecular weight 275.34
IUPAC name 1-(1,3-benzodioxol-5-yl)-2-pyrrolidin-1-ylpentan-1-one InChIKey SYHGEUNFJIGTRX-UHFFFAOYSA-N
LogP 2.863 Topological polar surface area 38.77
Hydrogen bond acceptor 4 Hydrogen bond donor 0

Synonym(s):
Methylenedioxypyrovalerone; MDPV; 687603-66-3; 1-(1,3-Benzodioxol-5-yl)-2-(1-pyrrolidinyl)-1-pentanone; 3,4-methylenedioxypyrovalerone; 1-Pentanone, 1-(1,3-benzodioxol-5-yl)-2-(1-pyrrolidinyl)-; MPDV cpd; MDPK; Pyrovalerone, methylendioxy-; Ivory Wave; (3,4)-methylenedioxypyrovalerone; Energy 1; DEA No. 7535; SCHEMBL15161948; HSDB 7980; DTXSID90897461; 1-(Benzo[d][1,3]dioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one; Q417010; 1-(1,3-benzodioxol-5-yl)-2-pyrrolidin-1-ylpentan-1-one; 1-(1,3-benzodioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one; MDPV; ; ; 1-(1,3-Benzodioxol-5-yl)-2-(1-pyrrolidinyl)-1-pentanone; (RS)-1-(benzo[d][1,3]dioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one

Activity data
Interaction ID 1141
Target type Molecule
Target unique ID 20111961
Activity 6.1 μM
Binding Conditions/Buffer

10 mM Tris-HCl, 0.5 mM MgCl2, 20 mM NaCl, pH 7.4
Assay

ITC characterization of MA binding to MDPV
PubMed ID 29361056
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_1081 DNA CTTACGACTGTGGTCGGGTGGTGGGCCTCTAGAGGGGTGTCGTAAG 60.87%
Apta_1080 DNA CTTACGACCCAGGGGGGTGGACAGGCGGGGGTTAGGGGGGTCGTAAG 59.57%
Apta_497 DNA GTTCGATTGGATTGTGCCGGAAGTGCTGGCTCGAAC 58.70%
Apta_307 DNA CATTCACCATGGCCCCTTCCTACGTATGTTCTGCGGGTG 56.52%
Apta_1191 DNA TAATACTACCAACTTCTTTGCCTGGCGTAAGTAACAGTCA 56.52%
Apta_591 DNA CTCTCGGGACGACGGCTGGCACGTTTGGTTCAAGAATGTGGGTGTCGTCCC 54.90%
Apta_697 DNA CTCTCGGGACGACGGACGCTAATCTTACAAGGGCGTAGTGTATGTCGTCCC 54.90%
Apta_1172 DNA GACGCCACTGACTACCCCAGTATCTCTTCAACGCGTATTGAAGTCAGTCGGTCGTCA 54.39%
Apta_195 DNA AGGAAGGCTTTAGGGGTCTGAGATCTCGGAAT 54.35%
Apta_273 DNA ATAAGCTGAGCATCTTAGATCCCCGTCAAGGGCAGCGTAA 54.35%
Apta_552 DNA CACCTGGGGGAGTATTGCGGAGGAAGGTTCCAGGTG 54.35%
Apta_577 DNA ACTTCAGTGAGTTGTCCCACGGTCGGCGAGTCGGTGGTAG 54.35%
Apta_699 DNA ATCTAACTGCTGCGCCGCCGGGAAAATACTGTACGGTTAGA 54.35%
Apta_820 DNA TCCCACGATCTCATTAGTCTGTGGATAAGCGTGGGACGTCTATGA 54.35%
Apta_939 DNA TTGCCCACCGTACTGTGCAGGTCGAACTACAGGCACGTCGTG 54.35%
Apta_1091 DNA CCATGGTAGGTATTGCTTGGTAGGGATAGTGGGCTTGATG 54.35%
Apta_1092 DNA CCCATGGTAGGTATTGCTTGGTAGGGATAGTGGGCTTGATG 54.35%
Apta_1215 DNA GTCGAATCAGCACCTCTGCATAGGTTACGTTTATACTGCG 54.35%
Apta_556 DNA GGCTCTCGGGACGACATGGATTTTCCATCAACGAAGTGCGTCCGTCCC 54.17%
Apta_974 DNA CATGGTGTCAATACTATACCTTTTGCCGATGGTAACAGTTGGTGGTATCC 54.00%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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