ProForma 2.0
Not calculated for this record
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-003679
MP
Aliases: Mastoparan-L, MP
Normalized sequence
INLKALAALAKKIL
14 amino acids
Release PepDiana-V1-20260620
4
Activity records
2
Source papers
4
Positive
0
Negative / threshold
Cross-layer links
Related Integrated records
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
Not calculated
Molecular formula
Not calculated
Theoretical pI
Not calculated
Net charge at pH 7
Not calculated
GRAVY
Not calculated
Instability index
Not calculated
Aromaticity
Not calculated
Topological polar surface area
Not calculated
cLogP
Not calculated
Hydrogen-bond donors
Not calculated
Hydrogen-bond acceptors
Not calculated
Rotatable bonds
Not calculated
Method: Not recorded
Tool: Not recorded
Calculated: Not recorded
Sequence representations
HELM 2.0
Not calculated for this record
Canonical SMILES
Not calculated for this record
Isomeric SMILES
Not calculated for this record
Paper-level observations
Experimental evidence grouped by activity
Toxicity 3 records
PMC10611374
2 observationsToxicityHemolyticPositive observation
Record detail Table 1: Mastoparan (L) HRBC EC50 82.9 ± 3.8 μM
- Measure
- EC50
- Value
- 82.9 ± 3.8 µM
- Target
- Homo sapiens
- Assay
- Not reported by source
ToxicityHemolyticPositive observation
Record detail Table 1: Mastoparan (L) RRBC EC50 242.5 ± 2.6 μM
- Measure
- EC50
- Value
- 242.5 ± 2.6 µM
- Target
- Rattus norvegicus
- Assay
- Not reported by source
PMC9065177
1 observationsToxicityHemolyticPositive observation
Record detail The potential of the stapled MP peptides to non-specifically lyse red blood cells (RBC) was measured and their hemolytic activities (HC50) determined. The peptide MP9 displayed the lowest level of RBC hemolysis.
- Measure
- HD50
- Value
- HC50 values not explicitly given for MP; MP9 displayed the lowest level of RBC hemolysis
- Target
- Mus musculus
- Assay
- Not reported by source
Anticancer 1 records
PMC9065177
1 observationsAnticancerCytotoxicPositive observation
Record detail These stapled peptides were evaluated for cytotoxicity in the CRC cell line CT26 in vitro, IC50 values ranged from 1.11 μM to 9.32 μM. These stapled MP derivatives exhibited either enhanced or same anti-CRC activity, in comparison to the parent MP.
- Measure
- other
- Value
- IC50 values ranged from 1.11 μM to 9.32 μM for stapled peptides; MP IC50 not explicitly given but stated stapled derivatives exhibited enhanced or same anti-CRC activity compared to parent MP
- Target
- CT26
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-003679, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00