ProForma 2.0
Not calculated for this record
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Primary-literature peptidemedium evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-003670
P
Aliases: P
Normalized sequence
ILGTILGLLKGL
12 amino acids
Release PepDiana-V1-20260620
7
Activity records
1
Source papers
5
Positive
2
Negative / threshold
Cross-layer links
Related Integrated records
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
Not calculated
Molecular formula
Not calculated
Theoretical pI
Not calculated
Net charge at pH 7
Not calculated
GRAVY
Not calculated
Instability index
Not calculated
Aromaticity
Not calculated
Topological polar surface area
Not calculated
cLogP
Not calculated
Hydrogen-bond donors
Not calculated
Hydrogen-bond acceptors
Not calculated
Rotatable bonds
Not calculated
Method: Not recorded
Tool: Not recorded
Calculated: Not recorded
Sequence representations
HELM 2.0
Not calculated for this record
Canonical SMILES
Not calculated for this record
Isomeric SMILES
Not calculated for this record
Paper-level observations
Experimental evidence grouped by activity
Antimicrobial 3 records
PMC10587126
3 observationsAntimicrobialAntibacterialPositive observation
Record detail the range of antimicrobial activity of the hybrid peptide matched, or came within one dilution, of that of the template AMP (protonecin and temporin A, 3.1–25 μmol L−1).
- Measure
- MIC
- Value
- 3.1–25 μmol L−1
- Target
- multiple bacteria
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail The MIC values of protonectin, PV and VP against P. aeruginosa were 128 μmol L−1 (Fig. 3a and Tables S1 and S2).
- Measure
- MIC
- Value
- 128 μmol L−1
- Target
- Pseudomonas aeruginosa
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Anoplin and protonectin were not active against Bacillus subtilis at the range of concentrations tested.
- Measure
- MIC
- Value
- not active
- Target
- Bacillus subtilis
- Assay
- Not reported by source
Anticancer 2 records
PMC10587126
2 observationsAnticancerCytotoxicPositive observation
Record detail Within 4 h of incubation with MCF-7, protonectin and temporin A reduced the counts of viable MCF-7 cells (LD50: 25 μmol L−1 and 50 μmol L−1, respectively).
- Measure
- other
- Value
- 25 μmol L−1 (LD50)
- Target
- MCF-7
- Assay
- Not reported by source
AnticancerCytotoxicPositive observation
Record detail After 24 h of incubation, protonectin and temporin A exhibited the same LD50 (LD50: 25 μmol L−1 and 50 μmol L−1, respectively).
- Measure
- other
- Value
- 25 μmol L−1 (LD50)
- Target
- MCF-7
- Assay
- Not reported by source
Toxicity 2 records
PMC10587126
2 observationsToxicityHemolyticPositive observation
Record detail The markedly improved hemolytic profile of VP (hemolytic at 100 μmol L−1) compared to the parent peptide protonectin (hemolytic at 12.5 μmol L−1) or to PV (hemolytic at 25 μmol L−1)
- Measure
- hemolysis
- Value
- hemolytic at 12.5 μmol L−1
- Target
- Homo sapiens
- Assay
- Not reported by source
ToxicityCytotoxicNegative / threshold
Record detail After 24 h of incubation, we did not observe peptide-meditated cytotoxicity towards MCF-10A cells (Fig. 3e).
- Measure
- cell_viability
- Value
- did not observe peptide-meditated cytotoxicity
- Target
- MCF-10A
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-003670, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00