ProForma 2.0
validated simple linear
WDDMEKIW
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-003152
P1
Aliases: P1
Normalized sequence
WDDMEKIW
8 amino acids
Release PepDiana-V1-20260620
1
Activity records
1
Source papers
1
Positive
0
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
1122.2498 Da
Molecular formula
C52H71N11O15S
Theoretical pI
4.05
Net charge at pH 7
-2.2358
GRAVY
-1.225
Instability index
-1.8625
Aromaticity
0.25
Topological polar surface area
436.52 Ų
cLogP
-0.0177
Hydrogen-bond donors
15
Hydrogen-bond acceptors
14
Rotatable bonds
35
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{W.D.D.M.E.K.I.W}$$$$V2.0
Canonical SMILES
validated
CCC(C)C(NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(N)Cc1c[nH]c2ccccc12)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O
Isomeric SMILES
validated
CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
Paper-level observations
Experimental evidence grouped by activity
Metabolic/Cardiovascular 1 records
PMC10001067
1 observationsMetabolic/CardiovascularXO InhibitorPositive observation
Record detail Table 3: XOI Activity of IC50 (mM) for WDDMEKIW is 3.16 ± 0.03. Text: 'The XOI activities of the peptides were highest in WW8 (IC50 = 3.16 ± 0.03 mM)'.
- Measure
- other
- Value
- 3.16 ± 0.03 mM
- Target
- Bos taurus
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-003152, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00