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Primary-literature peptidehigh evidence

PEPDIA-PLP-003007

OSTI-2483

Aliases: OSTI-2483

Normalized sequence

VKWKVKWKCWTKSKPPKPCKNH

22 amino acids

Release PepDiana-V1-20260620

43

Activity records

1

Source papers

39

Positive

4

Negative / threshold

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.

Computed properties

physchem-20260620

Molecular weight

2737.3399 Da

Molecular formula

C129H202N36O26S2

Theoretical pI

10.2472

Net charge at pH 7

7.7934

GRAVY

-1.5227

Instability index

5.4727

Aromaticity

0.1364

Topological polar surface area

1015.81 Å²

cLogP

-5.3124

Hydrogen-bond donors

37

Hydrogen-bond acceptors

37

Rotatable bonds

88

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620

ProForma 2.0

validated simple linear

VKWKVKWKCWTKSKPPKPCKNH

HELM 2.0

validated simple linear

PEPTIDE1{V.K.W.K.V.K.W.K.C.W.T.K.S.K.P.P.K.P.C.K.N.H}$$$$V2.0

Canonical SMILES

validated

CC(C)C(N)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCCN)C(=O)NC(CS)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CS)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(Cc1c[nH]cn1)C(=O)O)C(C)O)C(C)C

Isomeric SMILES

validated

CC(C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O)[C@@H](C)O)C(C)C

Paper-level observations

Experimental evidence grouped by activity

Antimicrobial 40 records

PMC12838809

40 observations

AntimicrobialAnti-Gram-Positive observation

Table 3: OSTI-2483 MIC 4 μM against E. coli ATCC CRM 8739

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: OSTI-2483 MBC 4 μM against E. coli ATCC CRM 8739

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: OSTI-2483 MIC 8 μM against E. coli BAA 2340

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 8 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: OSTI-2483 MBC 8 μM against E. coli BAA 2340

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 8 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: OSTI-2483 MIC 4 μM against E. coli NCTC 13846

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: OSTI-2483 MBC 4 μM against E. coli NCTC 13846

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: OSTI-2483 MIC 8 μM against P. aeruginosa ATCC CRM 9027

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 8 µM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: OSTI-2483 MBC 16 μM against P. aeruginosa ATCC CRM 9027

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 16 µM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: OSTI-2483 MIC 64 μM against K. pneumoniae ATCC CRM 43861

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 64 µM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: OSTI-2483 MBC 64 μM against K. pneumoniae ATCC CRM 43861

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 64 µM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: OSTI-2483 MIC 128 μM against A. baumannii BAA 747

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 128 µM
Target: Acinetobacter baumannii
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 3: OSTI-2483 MBC 128 μM against A. baumannii BAA 747

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 128 µM
Target: Acinetobacter baumannii
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram+Positive observation

Table 3: OSTI-2483 MIC 512 μM against S. aureus ATCC CRM 6538

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 512 µM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram+Positive observation

Table 3: OSTI-2483 MBC 512 μM against S. aureus ATCC CRM 6538

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 512 µM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram+Negative / threshold

Table 3: OSTI-2483 MIC >512 μM against E. faecium NCTC 12697

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: >512 µM
Target: Enterococcus faecium
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram+Positive observation

Table 3: OSTI-2483 MIC 8 μM against MRSA NCTC 12493

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 8 µM
Target: Methicillin-resistant Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram+Positive observation

Table 3: OSTI-2483 MBC 8 μM against MRSA NCTC 12493

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 8 µM
Target: Methicillin-resistant Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntifungalNegative / threshold

Table 3: OSTI-2483 MIC >512 μM against C. albicans ATCC 10231

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: >512 µM
Target: Candida albicans
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MIC 4 μM against E. coli ATCC CRM 8739 in 1% DMSO (control)

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MBC 4 μM against E. coli ATCC CRM 8739 in 1% DMSO (control)

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MIC 4 μM against E. coli ATCC CRM 8739 with FeCl3

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MBC 4 μM against E. coli ATCC CRM 8739 with FeCl3

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MIC 8 μM against E. coli ATCC CRM 8739 with CaCl2

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 8 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MBC 8 μM against E. coli ATCC CRM 8739 with CaCl2

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 8 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MIC 8 μM against E. coli ATCC CRM 8739 with NaCl

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 8 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MBC 8 μM against E. coli ATCC CRM 8739 with NaCl

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 8 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MIC 4 μM against E. coli ATCC CRM 8739 with KCl

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MBC 4 μM against E. coli ATCC CRM 8739 with KCl

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MIC 8 μM against E. coli ATCC CRM 8739 with MgCl2

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 8 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MBC 8 μM against E. coli ATCC CRM 8739 with MgCl2

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 8 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MIC 4 μM against E. coli ATCC CRM 8739 with NH4Cl

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MBC 4 μM against E. coli ATCC CRM 8739 with NH4Cl

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MIC 4 μM against E. coli ATCC CRM 8739 with Serum

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 4: OSTI-2483 MBC 8 μM against E. coli ATCC CRM 8739 with Serum

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 8 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 5: OSTI-2483 MIC 4 μM against E. coli ATCC CRM 8739 (Contrast)

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 5: OSTI-2483 MBC 4 μM against E. coli ATCC CRM 8739 (Contrast)

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 5: OSTI-2483 MIC 4 μM against E. coli ATCC CRM 8739 with 0.25 mg/mL trypsin

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 5: OSTI-2483 MBC 4 μM against E. coli ATCC CRM 8739 with 0.25 mg/mL trypsin

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 4 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 5: OSTI-2483 MIC 8 μM against E. coli ATCC CRM 8739 with 0.5 mg/mL trypsin

Mention PMC12838809::PEP000003PMC12838809table

Measure: MIC
Value: 8 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 5: OSTI-2483 MBC 16 μM against E. coli ATCC CRM 8739 with 0.5 mg/mL trypsin

Mention PMC12838809::PEP000003PMC12838809table

Measure: MBC
Value: 16 µM
Target: Escherichia coli
Assay: Not reported by source

Source publication

Toxicity 2 records

PMC12838809

2 observations

ToxicityHemolyticNegative / threshold

Section 3.8: OSTI-2483 produced little haemolysis, less than 10% even at the highest concentrations (1-512 μM) against horse erythrocytes

Mention PMC12838809::PEP000003PMC12838809text

Measure: hemolysis
Value: <10% at 1-512 μM
Target: horse
Assay: Not reported by source

Source publication

ToxicityCytotoxicNegative / threshold

Section 3.8: OSTI-2483 had minimal impact on HaCaT cell proliferation at 0.1-10 μM but reduced proliferation by more than 20% at 100 μM

Mention PMC12838809::PEP000003PMC12838809text

Measure: cell_viability
Value: minimal impact at 0.1-10 μM; >20% reduction at 100 μM
Target: HaCaT
Assay: Not reported by source

Source publication

Other 1 records

PMC12838809

1 observations

OtherProtease InhibitorPositive observation

Table 2: OSTI-2483 Trypsin Ki = 0.131 μM

Mention PMC12838809::PEP000003PMC12838809table

Measure: Ki
Value: 0.131 µM
Target: trypsin
Assay: Not reported by source

Source publication

Citation and release provenance

Cite this identity as PepDiana record PEPDIA-PLP-003007, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.

Record updated: 2026-06-22T07:14:26.229247+00:00