ProForma 2.0
validated simple linear
RHTPFFKG
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-002449
RHTPFFKG
Aliases: RHTPFFKG
Normalized sequence
RHTPFFKG
8 amino acids
Release PepDiana-V1-20260620
1
Activity records
1
Source papers
1
Positive
0
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
989.1306 Da
Molecular formula
C47H68N14O10
Theoretical pI
11.0008
Net charge at pH 7
1.8463
GRAVY
-1.0875
Instability index
18.075
Aromaticity
0.25
Topological polar surface area
395.06 Ų
cLogP
-2.8462
Hydrogen-bond donors
14
Hydrogen-bond acceptors
13
Rotatable bonds
29
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{R.H.T.P.F.F.K.G}$$$$V2.0
Canonical SMILES
validated
CC(O)C(NC(=O)C(Cc1c[nH]cn1)NC(=O)C(N)CCCNC(=N)N)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCCN)C(=O)NCC(=O)O
Isomeric SMILES
validated
C[C@@H](O)[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O
Paper-level observations
Experimental evidence grouped by activity
Other 1 records
PMC10056772
1 observationsOtherPositive observation
Record detail Table 2: RHTPFFKG, PepRank 0.77. Predicted bioactivity score from PeptideRanker.
- Measure
- other
- Value
- 0.77
- Target
- Not reported by source
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-002449, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00