ProForma 2.0
validated simple linear
RFGIISVRF
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-002415
RFGIISVRF
Aliases: RFGIISVRF
Normalized sequence
RFGIISVRF
9 amino acids
Release PepDiana-V1-20260620
1
Activity records
1
Source papers
1
Positive
0
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
1094.3091 Da
Molecular formula
C52H83N15O11
Theoretical pI
12
Net charge at pH 7
1.7601
GRAVY
0.9556
Instability index
-0.5444
Aromaticity
0.2222
Topological polar surface area
440.15 Ų
cLogP
-2.3395
Hydrogen-bond donors
17
Hydrogen-bond acceptors
13
Rotatable bonds
35
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{R.F.G.I.I.S.V.R.F}$$$$V2.0
Canonical SMILES
validated
CCC(C)C(NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(N)CCCNC(=N)N)C(=O)NC(C(=O)NC(CO)C(=O)NC(C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)O)C(C)C)C(C)CC
Isomeric SMILES
validated
CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)[C@@H](C)CC
Paper-level observations
Experimental evidence grouped by activity
Other 1 records
PMC10056772
1 observationsOtherPositive observation
Record detail Table 2: RFGIISVRF, PepRank 0.58. Predicted bioactivity score from PeptideRanker.
- Measure
- other
- Value
- 0.58
- Target
- Not reported by source
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-002415, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00