ProForma 2.0
validated simple linear
PGPMGPSGPR
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-002198
PGPMGPSGPR
Aliases: PGPMGPSGPR
Normalized sequence
PGPMGPSGPR
10 amino acids
Release PepDiana-V1-20260620
2
Activity records
1
Source papers
2
Positive
0
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
952.089 Da
Molecular formula
C40H65N13O12S
Theoretical pI
10.18
Net charge at pH 7
0.9585
GRAVY
-1.1
Instability index
13.18
Aromaticity
0
Topological polar surface area
366.99 Ų
cLogP
-5.3923
Hydrogen-bond donors
12
Hydrogen-bond acceptors
14
Rotatable bonds
24
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{P.G.P.M.G.P.S.G.P.R}$$$$V2.0
Canonical SMILES
validated
CSCCC(NC(=O)C1CCCN1C(=O)CNC(=O)C1CCCN1)C(=O)NCC(=O)N1CCCC1C(=O)NC(CO)C(=O)NCC(=O)N1CCCC1C(=O)NC(CCCNC(=N)N)C(=O)O
Isomeric SMILES
validated
CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Paper-level observations
Experimental evidence grouped by activity
Metabolic/Cardiovascular 2 records
PMC10001269
2 observationsMetabolic/CardiovascularACE InhibitorPositive observation
Record detail Table 3: ACE IC50 Seq6 (PGPMGPSGPR) 7.73 ± 0.54 mM. Text: 'only PGPMGPSGPR had an IC50 value below 10 mM'.
- Measure
- other
- Value
- 7.73 ± 0.54 other
- Target
- Oryctolagus cuniculus
- Assay
- Not reported by source
Metabolic/CardiovascularDPP-IV InhibitorPositive observation
Record detail Table 3: DPP-IV IC50 Seq6 (PGPMGPSGPR) 3.74 ± 0.52 mM.
- Measure
- other
- Value
- 3.74 ± 0.52 other
- Target
- DPP-IV
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-002198, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00