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Primary-literature peptidehigh evidence

PEPDIA-PLP-001901

P5

Aliases: P5

FASTA CSV JSON

Normalized sequence

LSNLGIVI

8 amino acids

Release PepDiana-V1-20260620

1

Activity records

1

Source papers

0

Positive

1

Negative / threshold

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.

Computed properties

physchem-20260620

Molecular weight

828.0079 Da

Molecular formula

C38H69N9O11

Theoretical pI

5.525

Net charge at pH 7

-0.2399

GRAVY

2.0125

Instability index

-12.475

Aromaticity

0

Topological polar surface area

330.34 Ų

cLogP

-1.8686

Hydrogen-bond donors

11

Hydrogen-bond acceptors

11

Rotatable bonds

27

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620

ProForma 2.0

validated simple linear

LSNLGIVI

HELM 2.0

validated simple linear

PEPTIDE1{L.S.N.L.G.I.V.I}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)C(N)CC(C)C)C(C)CC)C(C)C)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)CC)C(C)C)C(=O)O

Paper-level observations

Experimental evidence grouped by activity

Metabolic/Cardiovascular 1 records

PMC10001067

1 observations
Metabolic/CardiovascularXO InhibitorNegative / threshold
Record detail

Table 3: XOI Activity of IC50 (mM) for LSNLGIVI is NA. Text: 'LSNLGIVI, IGALRAVA, and HHTFYNELR did not even dissolve in water at 3 mg/mL, so these five peptides were neglected for the subsequent experiments.'

Mention PMC10001067::PEP000005PMC10001067table
Measure
other
Value
NA (did not dissolve in water at 3 mg/mL)
Target
Bos taurus
Assay
Not reported by source
Source publication

Citation and release provenance

Cite this identity as PepDiana record PEPDIA-PLP-001901, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.

Record updated: 2026-06-22T07:14:26.229247+00:00