Primary-literature peptidehigh evidence

PEPDIA-PLP-001846

Aliases: P4

FASTA CSV JSON

Normalized sequence

LNSADLIK

8 amino acids

Release PepDiana-V1-20260620

Activity records

Source papers

Positive

Negative / threshold

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.

Computed properties

physchem-20260620

Molecular weight

873.0056 Da

Molecular formula

C38H68N10O13

Theoretical pI

5.8357

Net charge at pH 7

-0.2398

GRAVY

0.275

Instability index

-12.475

Aromaticity

Topological polar surface area

393.66 Å²

cLogP

-3.5785

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620

ProForma 2.0

validated simple linear

LNSADLIK

HELM 2.0

validated simple linear

PEPTIDE1{L.N.S.A.D.L.I.K}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(N)CC(C)C)C(=O)NC(CCCCN)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O

Paper-level observations

Experimental evidence grouped by activity

Metabolic/Cardiovascular 1 records

PMC10001067

1 observations

Metabolic/CardiovascularXO InhibitorNegative / threshold

Record detail

Table 3: XOI Activity of IC50 (mM) for LNSADLIK is NA. Text: 'IADRMQKELT and LNSADLIK had no XOI activity at 15 mg/mL'.

Mention PMC10001067::PEP000004PMC10001067table

Measure: other
Value: NA (no XOI activity at 15 mg/mL)
Target: Bos taurus
Assay: Not reported by source

Source publication

Citation and release provenance

Cite this identity as PepDiana record PEPDIA-PLP-001846, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.

Record updated: 2026-06-22T07:14:26.229247+00:00