ProForma 2.0
validated simple linear
LLRLLRRGGRRLLRLLNH
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-001822
LRGG_chem
Aliases: LRGG_chem, LRGG_expr
Normalized sequence
LLRLLRRGGRRLLRLLNH
18 amino acids
Release PepDiana-V1-20260620
68
Activity records
1
Source papers
60
Positive
8
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
2225.7348 Da
Molecular formula
C98H181N39O20
Theoretical pI
12
Net charge at pH 7
5.8472
GRAVY
-0.2278
Instability index
107.3278
Aromaticity
0
Topological polar surface area
1001.19 Ų
cLogP
-7.3077
Hydrogen-bond donors
39
Hydrogen-bond acceptors
27
Rotatable bonds
79
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{L.L.R.L.L.R.R.G.G.R.R.L.L.R.L.L.N.H}$$$$V2.0
Canonical SMILES
validated
CC(C)CC(N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(=O)NC(Cc1c[nH]cn1)C(=O)O
Isomeric SMILES
validated
CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
Paper-level observations
Experimental evidence grouped by activity
Unknown 68 records
PMC11241267
68 observationsUnknownPositive observation
Record detail Table 1: Chem. Syn. LRGG MIC against Escherichia coli ATCC25922 = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Expressed LRGG MIC against Escherichia coli ATCC25922 = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Chem. Syn. LRGG MIC against S. pullorum NCTC5776 = 4 μg/mL
- Measure
- unknown
- Value
- 4 µg/mL
- Target
- Salmonella pullorum
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Expressed LRGG MIC against S. pullorum NCTC5776 = 4 μg/mL
- Measure
- unknown
- Value
- 4 µg/mL
- Target
- Salmonella pullorum
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Chem. Syn. LRGG MIC against K. pneumoniae ATCC46117 = 8 μg/mL
- Measure
- unknown
- Value
- 8 µg/mL
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Expressed LRGG MIC against K. pneumoniae ATCC46117 = 16 μg/mL
- Measure
- unknown
- Value
- 16 µg/mL
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Chem. Syn. LRGG MIC against P. aeruginosa ATCC27853 = 8 μg/mL
- Measure
- unknown
- Value
- 8 µg/mL
- Target
- Pseudomonas aeruginosa
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Expressed LRGG MIC against P. aeruginosa ATCC27853 = 8 μg/mL
- Measure
- unknown
- Value
- 8 µg/mL
- Target
- Pseudomonas aeruginosa
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Chem. Syn. LRGG MIC against S. flexneri CMCC51572 = 8 μg/mL
- Measure
- unknown
- Value
- 8 µg/mL
- Target
- Shigella flexneri
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Expressed LRGG MIC against S. flexneri CMCC51572 = 8 μg/mL
- Measure
- unknown
- Value
- 8 µg/mL
- Target
- Shigella flexneri
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Chem. Syn. LRGG MIC against Staphylococcus aureus ATCC25923 = 32 μg/mL
- Measure
- unknown
- Value
- 32 µg/mL
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Expressed LRGG MIC against Staphylococcus aureus ATCC25923 = 32 μg/mL
- Measure
- unknown
- Value
- 32 µg/mL
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Chem. Syn. LRGG MIC against S. aureus ATCC29213 = 16 μg/mL
- Measure
- unknown
- Value
- 16 µg/mL
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Expressed LRGG MIC against S. aureus ATCC29213 = 16 μg/mL
- Measure
- unknown
- Value
- 16 µg/mL
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Chem. Syn. LRGG MIC against Enterococcus faecalis ATCC29212 = 32 μg/mL
- Measure
- unknown
- Value
- 32 µg/mL
- Target
- Enterococcus faecalis
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Expressed LRGG MIC against Enterococcus faecalis ATCC29212 = 32 μg/mL
- Measure
- unknown
- Value
- 32 µg/mL
- Target
- Enterococcus faecalis
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Chem. Syn. LRGG MIC against MRSA = 256 μg/mL
- Measure
- unknown
- Value
- 256 µg/mL
- Target
- MRSA
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 1: Expressed LRGG MIC against MRSA = 128 μg/mL
- Measure
- unknown
- Value
- 128 µg/mL
- Target
- MRSA
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Chem. syn. LRGG MIC against E. coli ATCC25922, Control (pH 7) = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Expressed LRGG MIC against E. coli ATCC25922, Control (pH 7) = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Chem. syn. LRGG MIC against E. coli ATCC25922 at 0 °C = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Expressed LRGG MIC against E. coli ATCC25922 at 0 °C = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Chem. syn. LRGG MIC against E. coli ATCC25922 at 37 °C = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Expressed LRGG MIC against E. coli ATCC25922 at 37 °C = 4 μg/mL
- Measure
- unknown
- Value
- 4 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Chem. syn. LRGG MIC against E. coli ATCC25922 at 100 °C = 8 μg/mL
- Measure
- unknown
- Value
- 8 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Expressed LRGG MIC against E. coli ATCC25922 at 100 °C = 8 μg/mL
- Measure
- unknown
- Value
- 8 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Chem. syn. LRGG MIC against E. coli ATCC25922 at pH 4 = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Expressed LRGG MIC against E. coli ATCC25922 at pH 4 = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Chem. syn. LRGG MIC against E. coli ATCC25922 at pH 6 = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Expressed LRGG MIC against E. coli ATCC25922 at pH 6 = 4 μg/mL
- Measure
- unknown
- Value
- 4 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Chem. syn. LRGG MIC against E. coli ATCC25922 at pH 8 = 4 μg/mL
- Measure
- unknown
- Value
- 4 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Expressed LRGG MIC against E. coli ATCC25922 at pH 8 = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Chem. syn. LRGG MIC against E. coli ATCC25922 at pH 10 = 4 μg/mL
- Measure
- unknown
- Value
- 4 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 2: Expressed LRGG MIC against E. coli ATCC25922 at pH 10 = 16 μg/mL
- Measure
- unknown
- Value
- 16 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 3: Chem. syn. LRGG MIC against E. coli ATCC25922, Control = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 3: Expressed LRGG MIC against E. coli ATCC25922, Control = 4 μg/mL
- Measure
- unknown
- Value
- 4 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownNegative / threshold
Record detail Table 3: Chem. syn. LRGG MIC against E. coli ATCC25922 with Trypsin = >128 μg/mL
- Measure
- unknown
- Value
- >128 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownNegative / threshold
Record detail Table 3: Expressed LRGG MIC against E. coli ATCC25922 with Trypsin = >128 μg/mL
- Measure
- unknown
- Value
- >128 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownNegative / threshold
Record detail Table 3: Chem. syn. LRGG MIC against E. coli ATCC25922 with Pepsin = >128 μg/mL
- Measure
- unknown
- Value
- >128 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownNegative / threshold
Record detail Table 3: Expressed LRGG MIC against E. coli ATCC25922 with Pepsin = >128 μg/mL
- Measure
- unknown
- Value
- >128 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownNegative / threshold
Record detail Table 3: Chem. syn. LRGG MIC against E. coli ATCC25922 with Papain = >64 μg/mL
- Measure
- unknown
- Value
- >64 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownNegative / threshold
Record detail Table 3: Expressed LRGG MIC against E. coli ATCC25922 with Papain = >64 μg/mL
- Measure
- unknown
- Value
- >64 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownNegative / threshold
Record detail Table 3: Chem. syn. LRGG MIC against E. coli ATCC25922 with Protease K = >64 μg/mL
- Measure
- unknown
- Value
- >64 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownNegative / threshold
Record detail Table 3: Expressed LRGG MIC against E. coli ATCC25922 with Protease K = >64 μg/mL
- Measure
- unknown
- Value
- >64 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 4: Chem. Syn. LRGG MIC against E. coli ATCC25922, Control = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 4: Expressed LRGG MIC against E. coli ATCC25922, Control = 4 μg/mL
- Measure
- unknown
- Value
- 4 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 4: Chem. Syn. LRGG MIC against E. coli ATCC25922 in CaCl2 = 4 μg/mL
- Measure
- unknown
- Value
- 4 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 4: Expressed LRGG MIC against E. coli ATCC25922 in CaCl2 = 4 μg/mL
- Measure
- unknown
- Value
- 4 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 4: Chem. Syn. LRGG MIC against E. coli ATCC25922 in NaCl = 8 μg/mL
- Measure
- unknown
- Value
- 8 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 4: Expressed LRGG MIC against E. coli ATCC25922 in NaCl = 8 μg/mL
- Measure
- unknown
- Value
- 8 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 4: Chem. Syn. LRGG MIC against E. coli ATCC25922 in KCl = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 4: Expressed LRGG MIC against E. coli ATCC25922 in KCl = 8 μg/mL
- Measure
- unknown
- Value
- 8 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 4: Chem. Syn. LRGG MIC against E. coli ATCC25922 in NH4Cl = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 4: Expressed LRGG MIC against E. coli ATCC25922 in NH4Cl = 4 μg/mL
- Measure
- unknown
- Value
- 4 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 4: Chem. Syn. LRGG MIC against E. coli ATCC25922 in MgCl2 = 4 μg/mL
- Measure
- unknown
- Value
- 4 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 4: Expressed LRGG MIC against E. coli ATCC25922 in MgCl2 = 8 μg/mL
- Measure
- unknown
- Value
- 8 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 5: Chem. syn. LRGG MIC against E. coli ATCC25922, Control = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 5: Expressed LRGG MIC against E. coli ATCC25922, Control = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 5: Chem. syn. LRGG MIC against E. coli ATCC25922 in 5% serum = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 5: Expressed LRGG MIC against E. coli ATCC25922 in 5% serum = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 5: Chem. syn. LRGG MIC against E. coli ATCC25922 in 10% serum = 2 μg/mL
- Measure
- unknown
- Value
- 2 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 5: Expressed LRGG MIC against E. coli ATCC25922 in 10% serum = 4 μg/mL
- Measure
- unknown
- Value
- 4 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 5: Chem. syn. LRGG MIC against E. coli ATCC25922 in 20% serum = 8 μg/mL
- Measure
- unknown
- Value
- 8 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 5: Expressed LRGG MIC against E. coli ATCC25922 in 20% serum = 32 μg/mL
- Measure
- unknown
- Value
- 32 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 5: Chem. syn. LRGG MIC against E. coli ATCC25922 in 40% serum = 16 μg/mL
- Measure
- unknown
- Value
- 16 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 5: Expressed LRGG MIC against E. coli ATCC25922 in 40% serum = 32 μg/mL
- Measure
- unknown
- Value
- 32 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 5: Chem. syn. LRGG MIC against E. coli ATCC25922 in 50% serum = 16 μg/mL
- Measure
- unknown
- Value
- 16 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 5: Expressed LRGG MIC against E. coli ATCC25922 in 50% serum = 32 μg/mL
- Measure
- unknown
- Value
- 32 µg/mL
- Target
- Escherichia coli
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-001822, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00