ProForma 2.0
validated simple linear
LHKAR
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-001764
LAR5
Aliases: LAR5
Normalized sequence
LHKAR
5 amino acids
Release PepDiana-V1-20260620
6
Activity records
1
Source papers
2
Positive
4
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
623.7481 Da
Molecular formula
C27H49N11O6
Theoretical pI
11.0008
Net charge at pH 7
1.8463
GRAVY
-1.2
Instability index
55.36
Aromaticity
0
Topological polar surface area
296.32 Ų
cLogP
-2.2384
Hydrogen-bond donors
11
Hydrogen-bond acceptors
9
Rotatable bonds
21
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{L.H.K.A.R}$$$$V2.0
Canonical SMILES
validated
CC(C)CC(N)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)O
Isomeric SMILES
validated
CC(C)C[C@H](N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Paper-level observations
Experimental evidence grouped by activity
Immunomodulatory 4 records
PMC10221837
4 observationsImmunomodulatoryAnti-inflammatoryNegative / threshold
Record detail Table 1: LAR5 at 12.5 μg/mL, NO Inhibition Rate = 13.84 ± 0.04%.
- Measure
- percent_inhibition
- Value
- 13.84 ± 0.04%
- Target
- RAW264.7
- Assay
- Not reported by source
ImmunomodulatoryAnti-inflammatoryNegative / threshold
Record detail Table 1: LAR5 at 25 μg/mL, NO Inhibition Rate = 13.51 ± 0.04%.
- Measure
- percent_inhibition
- Value
- 13.51 ± 0.04%
- Target
- RAW264.7
- Assay
- Not reported by source
ImmunomodulatoryAnti-inflammatoryNegative / threshold
Record detail Table 1: LAR5 at 50 μg/mL, NO Inhibition Rate = 11.05 ± 0.04%.
- Measure
- percent_inhibition
- Value
- 11.05 ± 0.04%
- Target
- RAW264.7
- Assay
- Not reported by source
ImmunomodulatoryAnti-inflammatoryNegative / threshold
Record detail Table 1: LAR5 at 100 μg/mL, NO Inhibition Rate = 7.72 ± 0.08%.
- Measure
- percent_inhibition
- Value
- 7.72 ± 0.08%
- Target
- RAW264.7
- Assay
- Not reported by source
Antioxidant 2 records
PMC10221837
2 observationsAntioxidantPositive observation
Record detail Compared with the original pentapeptide LR5, the IC50 values of the replacement pentapeptides AR5 and LAR5 with reduced hydrophobicity increased from 2.6561 ± 0.0031 mmol/L to 6.985 ± 0.0002 mmol/L (p < 0.01) and 3.633 ± 0.0071 mmol/L (p < 0.01), respectively.
- Measure
- other
- Value
- 3.633 ± 0.0071 mmol/L
- Target
- Not reported by source
- Assay
- Not reported by source
AntioxidantPositive observation
Record detail Compared with the original pentapeptide LR5, the IC50 values of the replacement pentapeptides AR5 and LAR5 increased from 0.6476 ± 0.0032 mmol/L to 0.6702 ± 0.0019 mmol/L (p < 0.05) and 0.6561 ± 0.0025 mmol/L (p < 0.05), respectively.
- Measure
- other
- Value
- 0.6561 ± 0.0025 mmol/L
- Target
- Not reported by source
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-001764, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00