PEPDIA-PLP-001503

Table 3: BP76 MIC 25 µg/ml against S. aureus ATCC 29213

Table 3: BP76 MBC 25 µg/ml against S. aureus ATCC 29213

Table 3: BP76 MIC 50 µg/ml against S. aureus MRSA USA 300

Table 3: BP76 MBC 50 µg/ml against S. aureus MRSA USA 300

Table 3: BP76 MIC 50 µg/ml against P. aeruginosa ATCC 27853

Table 3: BP76 MBC 50 µg/ml against P. aeruginosa ATCC 27853

Table 3: BP76 MIC 50 µg/ml against P. aeruginosa ST175-1

Table 3: BP76 MBC 50 µg/ml against P. aeruginosa ST175-1

Table 3: BP76 MIC 6.25 µg/ml against A. baumannii ATCC 19606

Table 3: BP76 MBC 6.25 µg/ml against A. baumannii ATCC 19606

Table 3: BP76 MIC 25 µg/ml against A. baumannii IB010

Table 3: BP76 MBC 25 µg/ml against A. baumannii IB010

Table 3: BP76 MIC 12.5 µg/ml against A. baumannii Ab-1

Table 3: BP76 MBC 12.5 µg/ml against A. baumannii Ab-1

Table 3: BP76 MIC 12.5 µg/ml against K. pneumoniae ATCC 43816

Table 3: BP76 MBC 12.5 µg/ml against K. pneumoniae ATCC 43816

Table 3: BP76 MIC 6.25 µg/ml against K. pneumoniae CG258

Table 3: BP76 MBC 6.25 µg/ml against K. pneumoniae CG258

Table 3: BP76 MIC 6.25 µg/ml against E. coli ATCC 25922

Table 3: BP76 MBC 6.25 µg/ml against E. coli ATCC 25922

Table 3: BP76 MIC 12.5 µg/ml against E. coli ESBL 1057.1

Table 3: BP76 MBC 12.5 µg/ml against E. coli ESBL 1057.1

Section 3.4: BP76 reduced SBF indices compared to BP607 for K. pneumoniae ATCC 43816 (Fig. 3)

Section 3.4: BP76 reduced production of biofilm for K. pneumoniae CG258 (Fig. 3)

Section 3.4: BP76 reduced production of biofilm for E. coli ATCC 25922 (Fig. 3)

Section 3.3: BP76 was able to reduce growth to bactericidal level at 6h, but not at 24h against K. pneumoniae CG258 at 2x MIC

Section 3.3: at 2x MIC, all three peptides bactericidal for A. baumannii ATCC 19606 at 6 and 24h

Section 3.3: at 2x MIC, all three peptides bactericidal for E. coli ESBL 1057.1 at 6 and 24h

Section 3.3: all three peptides were bactericidal for E. coli ESBL 1057.1 at 6 and 24h at MIC

Section 3.3: BP76 displayed bactericidal activity at 6h but not at 24h against K. pneumoniae CG258 at MIC

Section 3.3: none of the peptides were bactericidal for A. baumannii ATCC 19606 at 6h or 24h at MIC

Section 3.1: BP76 inhibited growth of all strains by ≈90% at 50 µg/ml

Abstract: BP76 inhibited ≥76.77% of K. pneumoniae biofilm formation at subinhibitory concentrations

Abstract: BP76 inhibited ≥76.77% of E. coli biofilm formation at subinhibitory concentrations

Section 3.1: BP125 inhibited ≥83% of growth in all strains except for both K. pneumoniae and E. coli ATCC 25922

Section 3.1: 13 peptides reduced growth of all A. baumannii strains at least 83%

Section 3.1: 11 peptides reduced growth at least 80% in E. coli strains

Section 3.1: eight compounds were able to reduce over 92% of growth in K. pneumoniae strains

Section 3.1: five out of 26 compounds reduced at least 88% of growth in P. aeruginosa strains

Section 3.1: five peptides able to inhibit growth ≥83% in S. aureus

Section 3.1: BP475, BP181, BP179, BP241 and BP171 mainly reduced growth of A. baumannii, K. pneumoniae and E. coli strains with values ranging between 74% and 95%

Section 3.5: BP76 showed 15% peptide remaining after 60 min in human serum

Table 1: BP76 hemolysis 34±2.1% at 150 µM

Section 3.6: BP76 presented less toxicity than colistin with 100% survival after 24h (Fig. 5B)