ProForma 2.0
validated simple linear
IKWLNISAATGILGRIALKSGPL
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-001302
pep_AR23_scramble
Aliases: pep_AR23_scramble
Normalized sequence
IKWLNISAATGILGRIALKSGPL
23 amino acids
Release PepDiana-V1-20260620
1
Activity records
1
Source papers
1
Positive
0
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
2392.8802 Da
Molecular formula
C111H190N30O28
Theoretical pI
11.1663
Net charge at pH 7
2.7581
GRAVY
0.7304
Instability index
27.6435
Aromaticity
0.0435
Topological polar surface area
928.24 Ų
cLogP
-6.6211
Hydrogen-bond donors
33
Hydrogen-bond acceptors
31
Rotatable bonds
79
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{I.K.W.L.N.I.S.A.A.T.G.I.L.G.R.I.A.L.K.S.G.P.L}$$$$V2.0
Canonical SMILES
validated
CCC(C)C(N)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CO)C(=O)NC(C)C(=O)NC(C)C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NCC(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)O)C(C)CC)C(C)CC)C(C)O)C(C)CC
Isomeric SMILES
validated
CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC
Paper-level observations
Experimental evidence grouped by activity
Antiviral 1 records
PMC10609114
1 observationsAntiviralGeneral AntiviralPositive observation
Record detail Using the data obtained from RV-23 and AR-23 scramble peptides (Figure 2B,D), we can hypothesize that the antiviral activity ... was strongly associated with the peptide primary sequence. Figure 2D shows no significant inhibition by AR-23 scramble.
- Measure
- percent_inhibition
- Value
- no significant activity
- Target
- Vero
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-001302, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00