Primary-literature peptidehigh evidence

PEPDIA-PLP-001267

Aliases: P6

FASTA CSV JSON

Normalized sequence

IGALRAVA

8 amino acids

Release PepDiana-V1-20260620

Activity records

Source papers

Positive

Negative / threshold

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.

Computed properties

physchem-20260620

Molecular weight

769.9322 Da

Molecular formula

C34H63N11O9

Theoretical pI

9.75

Net charge at pH 7

0.7601

GRAVY

1.625

Instability index

22.2125

Aromaticity

Topological polar surface area

328.92 Å²

cLogP

-2.5055

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620

ProForma 2.0

validated simple linear

IGALRAVA

HELM 2.0

validated simple linear

PEPTIDE1{I.G.A.L.R.A.V.A}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(N)C(=O)NCC(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(C)C(=O)NC(C(=O)NC(C)C(=O)O)C(C)C

Isomeric SMILES

validated

CC[C@H](C)[C@H](N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)C(C)C

Paper-level observations

Experimental evidence grouped by activity

Metabolic/Cardiovascular 1 records

PMC10001067

1 observations

Metabolic/CardiovascularXO InhibitorNegative / threshold

Record detail

Table 3: XOI Activity of IC50 (mM) for IGALRAVA is NA. Text: 'LSNLGIVI, IGALRAVA, and HHTFYNELR did not even dissolve in water at 3 mg/mL, so these five peptides were neglected for the subsequent experiments.'

Mention PMC10001067::PEP000006PMC10001067table

Measure: other
Value: NA (did not dissolve in water at 3 mg/mL)
Target: Bos taurus
Assay: Not reported by source

Source publication

Citation and release provenance

Cite this identity as PepDiana record PEPDIA-PLP-001267, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.

Record updated: 2026-06-22T07:14:26.229247+00:00