ProForma 2.0
validated simple linear
HHTFYNELR
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-001184
P7
Aliases: P7
Normalized sequence
HHTFYNELR
9 amino acids
Release PepDiana-V1-20260620
1
Activity records
1
Source papers
0
Positive
1
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
1216.3047 Da
Molecular formula
C55H77N17O15
Theoretical pI
6.9209
Net charge at pH 7
-0.0637
GRAVY
-1.4778
Instability index
71.8456
Aromaticity
0.2222
Topological polar surface area
536.23 Ų
cLogP
-4.1703
Hydrogen-bond donors
19
Hydrogen-bond acceptors
17
Rotatable bonds
37
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{H.H.T.F.Y.N.E.L.R}$$$$V2.0
Canonical SMILES
validated
CC(C)CC(NC(=O)C(CCC(=O)O)NC(=O)C(CC(N)=O)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(Cc1c[nH]cn1)NC(=O)C(N)Cc1c[nH]cn1)C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)O
Isomeric SMILES
validated
CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Paper-level observations
Experimental evidence grouped by activity
Metabolic/Cardiovascular 1 records
PMC10001067
1 observationsMetabolic/CardiovascularXO InhibitorNegative / threshold
Record detail Table 3: XOI Activity of IC50 (mM) for HHTFYNELR is NA. Text: 'LSNLGIVI, IGALRAVA, and HHTFYNELR did not even dissolve in water at 3 mg/mL, so these five peptides were neglected for the subsequent experiments.'
- Measure
- other
- Value
- NA (did not dissolve in water at 3 mg/mL)
- Target
- Bos taurus
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-001184, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00