ProForma 2.0
validated simple linear
GPAGPAGPIGPVG
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-001050
GPAGPAGPIGPVG
Aliases: GPAGPAGPIGPVG
Normalized sequence
GPAGPAGPIGPVG
13 amino acids
Release PepDiana-V1-20260620
2
Activity records
1
Source papers
2
Positive
0
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
1046.177 Da
Molecular formula
C47H75N13O14
Theoretical pI
5.525
Net charge at pH 7
-0.2399
GRAVY
0.3
Instability index
47.1462
Aromaticity
0
Topological polar surface area
377.36 Ų
cLogP
-4.8604
Hydrogen-bond donors
10
Hydrogen-bond acceptors
14
Rotatable bonds
24
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{G.P.A.G.P.A.G.P.I.G.P.V.G}$$$$V2.0
Canonical SMILES
validated
CCC(C)C(NC(=O)C1CCCN1C(=O)CNC(=O)C(C)NC(=O)C1CCCN1C(=O)CNC(=O)C(C)NC(=O)C1CCCN1C(=O)CN)C(=O)NCC(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)O)C(C)C
Isomeric SMILES
validated
CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)CN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)C(C)C
Paper-level observations
Experimental evidence grouped by activity
Metabolic/Cardiovascular 2 records
PMC10001269
2 observationsMetabolic/CardiovascularACE InhibitorPositive observation
Record detail Table 3: ACE IC50 Seq4 (GPAGPAGPIGPVG) 17.07 ± 2.45 mM.
- Measure
- other
- Value
- 17.07 ± 2.45 other
- Target
- Oryctolagus cuniculus
- Assay
- Not reported by source
Metabolic/CardiovascularDPP-IV InhibitorPositive observation
Record detail Table 3: DPP-IV IC50 Seq4 (GPAGPAGPIGPVG) 0.07 ± 0.01 mM. Text: 'GPAGPAGPIGPVG had the best inhibition ability on DPP-IV, with a low IC50 value of 0.07 ± 0.01 mM'.
- Measure
- other
- Value
- 0.07 ± 0.01 other
- Target
- DPP-IV
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-001050, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00