ProForma 2.0
validated simple linear
FLQHIIGALGRLF
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-000750
GHa11R
Aliases: GHa11R
Normalized sequence
FLQHIIGALGRLF
13 amino acids
Release PepDiana-V1-20260620
11
Activity records
1
Source papers
10
Positive
1
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
1484.7856 Da
Molecular formula
C72H113N19O15
Theoretical pI
9.7565
Net charge at pH 7
0.8473
GRAVY
1.2154
Instability index
61.5769
Aromaticity
0.1538
Topological polar surface area
546.19 Ų
cLogP
-1.2909
Hydrogen-bond donors
19
Hydrogen-bond acceptors
17
Rotatable bonds
48
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{F.L.Q.H.I.I.G.A.L.G.R.L.F}$$$$V2.0
Canonical SMILES
validated
CCC(C)C(NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(N)Cc1ccccc1)C(=O)NC(C(=O)NCC(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)O)C(C)CC
Isomeric SMILES
validated
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC
Paper-level observations
Experimental evidence grouped by activity
Unknown 11 records
PMC10562637
11 observationsUnknownPositive observation
Record detail Table 3: S. mutans UA159, GHa11R MIC/MBC 3.1/6.2 μM
- Measure
- unknown
- Value
- 3.1 μM
- Target
- Streptococcus mutans
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 3: S. mutans UA159, GHa11R MIC/MBC 3.1/6.2 μM
- Measure
- unknown
- Value
- 6.2 μM
- Target
- Streptococcus mutans
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 3: S. sanguis ATCC 10556, GHa11R MIC/MBC 6.2/12.5 μM
- Measure
- unknown
- Value
- 6.2 μM
- Target
- Streptococcus sanguis
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 3: S. sanguis ATCC 10556, GHa11R MIC/MBC 6.2/12.5 μM
- Measure
- unknown
- Value
- 12.5 μM
- Target
- Streptococcus sanguis
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 3: P. gingivalis ATCC 33277, GHa11R MIC/MBC 6.2/12.5 μM
- Measure
- unknown
- Value
- 6.2 μM
- Target
- Porphyromonas gingivalis
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 3: P. gingivalis ATCC 33277, GHa11R MIC/MBC 6.2/12.5 μM
- Measure
- unknown
- Value
- 12.5 μM
- Target
- Porphyromonas gingivalis
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 3: B. adolescentis ATCC 15703, GHa11R MIC/MBC 25/25 μM
- Measure
- unknown
- Value
- 25 μM
- Target
- Bifidobacterium adolescentis
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 3: B. breve ATCC 15700, GHa11R MIC/MBC 100/100 μM
- Measure
- unknown
- Value
- 100 μM
- Target
- Bifidobacterium breve
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 3: L. acidophilus ATCC 4356, GHa11R MIC/MBC 50/100 μM
- Measure
- unknown
- Value
- 50 μM
- Target
- Lactobacillus acidophilus
- Assay
- Not reported by source
UnknownPositive observation
Record detail Table 3: L. acidophilus ATCC 4356, GHa11R MIC/MBC 50/100 μM
- Measure
- unknown
- Value
- 100 μM
- Target
- Lactobacillus acidophilus
- Assay
- Not reported by source
UnknownNegative / threshold
Record detail GHa11R had no toxic effect on HOK cells at a concentration of 100 μM; IC50 >100 μM
- Measure
- unknown
- Value
- >100 μM
- Target
- HOK
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-000750, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00