Primary-literature peptidehigh evidence

PEPDIA-PLP-000713

pep_RV23_scramble

Aliases: pep_RV23_scramble

FASTA CSV JSON

Normalized sequence

FGILAKSVVRPKGRKFLKLMLLL

23 amino acids

Release PepDiana-V1-20260620

Activity records

Source papers

Positive

Negative / threshold

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.

Computed properties

physchem-20260620

Molecular weight

2628.3577 Da

Molecular formula

C126H219N33O25S

Theoretical pI

Net charge at pH 7

5.7561

GRAVY

0.7478

Instability index

11.5478

Aromaticity

0.087

Topological polar surface area

942.84 Å²

cLogP

-2.2392

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620

ProForma 2.0

validated simple linear

FGILAKSVVRPKGRKFLKLMLLL

HELM 2.0

validated simple linear

PEPTIDE1{F.G.I.L.A.K.S.V.V.R.P.K.G.R.K.F.L.K.L.M.L.L.L}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)CNC(=O)C(N)Cc1ccccc1)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(C(=O)NC(C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(Cc1ccccc1)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O)C(C)C)C(C)C

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)C)C(C)C

Paper-level observations

Experimental evidence grouped by activity

Antiviral 1 records

PMC10609114

1 observations

AntiviralGeneral AntiviralPositive observation

Record detail

Using the data obtained from RV-23 and AR-23 scramble peptides (Figure 2B,D), we can hypothesize that the antiviral activity ... was strongly associated with the peptide primary sequence. Figure 2B shows no significant inhibition by RV-23 scramble.

Mention PMC10609114::PEP000003PMC10609114text

Measure: percent_inhibition
Value: no significant activity
Target: Vero
Assay: Not reported by source

Source publication

Citation and release provenance

Cite this identity as PepDiana record PEPDIA-PLP-000713, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.

Record updated: 2026-06-22T07:14:26.229247+00:00