ProForma 2.0
validated simple linear
FGFDGDF
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-000709
FGFDGDF
Aliases: FGFDGDF
Normalized sequence
FGFDGDF
7 amino acids
Release PepDiana-V1-20260620
2
Activity records
1
Source papers
1
Positive
1
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
803.8141 Da
Molecular formula
C39H45N7O12
Theoretical pI
4.05
Net charge at pH 7
-2.2377
GRAVY
0.0857
Instability index
15.4286
Aromaticity
0.4286
Topological polar surface area
312.52 Ų
cLogP
-1.7526
Hydrogen-bond donors
10
Hydrogen-bond acceptors
10
Rotatable bonds
23
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{F.G.F.D.G.D.F}$$$$V2.0
Canonical SMILES
validated
NC(Cc1ccccc1)C(=O)NCC(=O)NC(Cc1ccccc1)C(=O)NC(CC(=O)O)C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(Cc1ccccc1)C(=O)O
Isomeric SMILES
validated
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Paper-level observations
Experimental evidence grouped by activity
Metabolic/Cardiovascular 2 records
PMC10001269
2 observationsMetabolic/CardiovascularACE InhibitorNegative / threshold
Record detail Table 3: ACE IC50 Seq3 (FGFDGDF) ND (not detected). Text: 'The IC50 value on ACE of FGFDGDF was not determined due to its low predicted score as AHTP'.
- Measure
- other
- Value
- ND
- Target
- Oryctolagus cuniculus
- Assay
- Not reported by source
Metabolic/CardiovascularDPP-IV InhibitorPositive observation
Record detail Table 3: DPP-IV IC50 Seq3 (FGFDGDF) 0.59 ± 0.07 mM.
- Measure
- other
- Value
- 0.59 ± 0.07 other
- Target
- DPP-IV
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-000709, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00