ProForma 2.0
validated simple linear
ELVFYRP
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-000598
SA905
Aliases: SA905
Normalized sequence
ELVFYRP
7 amino acids
Release PepDiana-V1-20260620
2
Activity records
1
Source papers
1
Positive
1
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
923.0658 Da
Molecular formula
C45H66N10O11
Theoretical pI
6.1007
Net charge at pH 7
-0.1642
GRAVY
-0.0143
Instability index
58.5014
Aromaticity
0.2857
Topological polar surface area
348.56 Ų
cLogP
-0.1655
Hydrogen-bond donors
12
Hydrogen-bond acceptors
11
Rotatable bonds
26
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{E.L.V.F.Y.R.P}$$$$V2.0
Canonical SMILES
validated
CC(C)CC(NC(=O)C(N)CCC(=O)O)C(=O)NC(C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)O)C(C)C
Isomeric SMILES
validated
CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)O)C(C)C
Paper-level observations
Experimental evidence grouped by activity
Anticancer 1 records
PMC10045366
1 observationsAnticancerCytotoxicPositive observation
Record detail The SA923 peptide exhibited a potent cytotoxic effect of 89%; when compared to the same dose of SA626, 37%; and SA905, 54%.
- Measure
- percent_inhibition
- Value
- 54%
- Target
- 3T3
- Assay
- MTT assay
Toxicity 1 records
PMC10045366
1 observationsToxicityGeneral ToxicNegative / threshold
Record detail Embryos exposed to different concentrations did not display any visible anomalies. ... peptides from S. amaranthoides do not demonstrate any toxic effect on embryos.
- Measure
- qualitative
- Value
- no toxic effect
- Target
- Danio rerio
- Assay
- Zebrafish embryo toxicity test
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-000598, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00