ProForma 2.0
validated simple linear
ELVFYRD
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-000597
SA923
Aliases: SA923
Normalized sequence
ELVFYRD
7 amino acids
Release PepDiana-V1-20260620
2
Activity records
1
Source papers
1
Positive
1
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
941.038 Da
Molecular formula
C44H64N10O13
Theoretical pI
4.6699
Net charge at pH 7
-1.1599
GRAVY
-0.2857
Instability index
30.9871
Aromaticity
0.2857
Topological polar surface area
394.65 Ų
cLogP
-1.197
Hydrogen-bond donors
14
Hydrogen-bond acceptors
12
Rotatable bonds
29
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{E.L.V.F.Y.R.D}$$$$V2.0
Canonical SMILES
validated
CC(C)CC(NC(=O)C(N)CCC(=O)O)C(=O)NC(C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)O)C(=O)O)C(C)C
Isomeric SMILES
validated
CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)O)C(C)C
Paper-level observations
Experimental evidence grouped by activity
Anticancer 1 records
PMC10045366
1 observationsAnticancerCytotoxicPositive observation
Record detail The SA923 peptide exhibited a potent cytotoxic effect of 89%; when compared to the same dose of SA626, 37%; and SA905, 54%.
- Measure
- percent_inhibition
- Value
- 89%
- Target
- 3T3
- Assay
- MTT assay
Toxicity 1 records
PMC10045366
1 observationsToxicityGeneral ToxicNegative / threshold
Record detail Embryos exposed to different concentrations did not display any visible anomalies. ... peptides from S. amaranthoides do not demonstrate any toxic effect on embryos.
- Measure
- qualitative
- Value
- no toxic effect
- Target
- Danio rerio
- Assay
- Zebrafish embryo toxicity test
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-000597, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00