ProForma 2.0
validated simple linear
CKRIVQRIKDFLRNH
Back to Primary literature
Primary-literature peptidemedium evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-000314
V
Aliases: II, III, IV, V, VI, VII
Normalized sequence
CKRIVQRIKDFLRNH
15 amino acids
Release PepDiana-V1-20260620
63
Activity records
1
Source papers
56
Positive
7
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
1926.296 Da
Molecular formula
C84H144N30O20S
Theoretical pI
10.9164
Net charge at pH 7
3.8365
GRAVY
-0.8467
Instability index
35.7867
Aromaticity
0.0667
Topological polar surface area
860.62 Ų
cLogP
-7.2185
Hydrogen-bond donors
32
Hydrogen-bond acceptors
26
Rotatable bonds
68
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{C.K.R.I.V.Q.R.I.K.D.F.L.R.N.H}$$$$V2.0
Canonical SMILES
validated
CCC(C)C(NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(N)=O)NC(=O)C(NC(=O)C(NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(N)CS)C(C)CC)C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(Cc1ccccc1)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(N)=O)C(=O)NC(Cc1c[nH]cn1)C(=O)O
Isomeric SMILES
validated
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CS)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
Paper-level observations
Experimental evidence grouped by activity
Antimicrobial 57 records
PMC11990879
57 observationsAntimicrobialAntifungalPositive observation
Record detail Table 2: Compound II, C. albicans MIC 128 mg/L.
- Measure
- MIC
- Value
- 128 other
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound II, C. albicans MFC 256 mg/L.
- Measure
- other
- Value
- 256 (MFC)
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound II, C. glabrata MIC 256 mg/L.
- Measure
- MIC
- Value
- 256 other
- Target
- Candida glabrata
- Assay
- Not reported by source
AntimicrobialAntifungalNegative / threshold
Record detail Table 2: Compound II, C. glabrata MFC >256 mg/L.
- Measure
- other
- Value
- >256 (MFC)
- Target
- Candida glabrata
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound II, C. lipolytica MIC 32 mg/L.
- Measure
- MIC
- Value
- 32 other
- Target
- Candida lipolytica
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound II, C. lipolytica MFC 64 mg/L.
- Measure
- other
- Value
- 64 (MFC)
- Target
- Candida lipolytica
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound II, C. tropicalis MIC 16 mg/L.
- Measure
- MIC
- Value
- 16 other
- Target
- Candida tropicalis
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound II, C. tropicalis MFC 16 mg/L.
- Measure
- other
- Value
- 16 (MFC)
- Target
- Candida tropicalis
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound III, C. albicans MIC 64 mg/L.
- Measure
- MIC
- Value
- 64 other
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound III, C. albicans MFC 128 mg/L.
- Measure
- other
- Value
- 128 (MFC)
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound III, C. glabrata MIC 128 mg/L.
- Measure
- MIC
- Value
- 128 other
- Target
- Candida glabrata
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound III, C. glabrata MFC 256 mg/L.
- Measure
- other
- Value
- 256 (MFC)
- Target
- Candida glabrata
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound III, C. lipolytica MIC 16 mg/L.
- Measure
- MIC
- Value
- 16 other
- Target
- Candida lipolytica
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound III, C. lipolytica MFC 32 mg/L.
- Measure
- other
- Value
- 32 (MFC)
- Target
- Candida lipolytica
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound III, C. tropicalis MIC 8 mg/L.
- Measure
- MIC
- Value
- 8 other
- Target
- Candida tropicalis
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound III, C. tropicalis MFC 16 mg/L.
- Measure
- other
- Value
- 16 (MFC)
- Target
- Candida tropicalis
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound IV, C. albicans MIC 32 mg/L.
- Measure
- MIC
- Value
- 32 other
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound IV, C. albicans MFC 64 mg/L.
- Measure
- other
- Value
- 64 (MFC)
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound IV, C. glabrata MIC 32 mg/L.
- Measure
- MIC
- Value
- 32 other
- Target
- Candida glabrata
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound IV, C. glabrata MFC 64 mg/L.
- Measure
- other
- Value
- 64 (MFC)
- Target
- Candida glabrata
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound IV, C. lipolytica MIC 8 mg/L.
- Measure
- MIC
- Value
- 8 other
- Target
- Candida lipolytica
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound IV, C. lipolytica MFC 16 mg/L.
- Measure
- other
- Value
- 16 (MFC)
- Target
- Candida lipolytica
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound IV, C. tropicalis MIC 8 mg/L.
- Measure
- MIC
- Value
- 8 other
- Target
- Candida tropicalis
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound IV, C. tropicalis MFC 8 mg/L.
- Measure
- other
- Value
- 8 (MFC)
- Target
- Candida tropicalis
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound V, C. albicans MIC 16 mg/L.
- Measure
- MIC
- Value
- 16 other
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound V, C. albicans MFC 32 mg/L.
- Measure
- other
- Value
- 32 (MFC)
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound V, C. glabrata MIC 8 mg/L.
- Measure
- MIC
- Value
- 8 other
- Target
- Candida glabrata
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound V, C. glabrata MFC 8 mg/L.
- Measure
- other
- Value
- 8 (MFC)
- Target
- Candida glabrata
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound V, C. lipolytica MIC 4 mg/L.
- Measure
- MIC
- Value
- 4 other
- Target
- Candida lipolytica
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound V, C. lipolytica MFC 8 mg/L.
- Measure
- other
- Value
- 8 (MFC)
- Target
- Candida lipolytica
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound V, C. tropicalis MIC 4 mg/L.
- Measure
- MIC
- Value
- 4 other
- Target
- Candida tropicalis
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound V, C. tropicalis MFC 4 mg/L.
- Measure
- other
- Value
- 4 (MFC)
- Target
- Candida tropicalis
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VI, C. albicans MIC 8 mg/L.
- Measure
- MIC
- Value
- 8 other
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VI, C. albicans MFC 16 mg/L.
- Measure
- other
- Value
- 16 (MFC)
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VI, C. glabrata MIC 4 mg/L.
- Measure
- MIC
- Value
- 4 other
- Target
- Candida glabrata
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VI, C. glabrata MFC 4 mg/L.
- Measure
- other
- Value
- 4 (MFC)
- Target
- Candida glabrata
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VI, C. lipolytica MIC 4 mg/L.
- Measure
- MIC
- Value
- 4 other
- Target
- Candida lipolytica
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VI, C. lipolytica MFC 4 mg/L.
- Measure
- other
- Value
- 4 (MFC)
- Target
- Candida lipolytica
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VI, C. tropicalis MIC 4 mg/L.
- Measure
- MIC
- Value
- 4 other
- Target
- Candida tropicalis
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VI, C. tropicalis MFC 4 mg/L.
- Measure
- other
- Value
- 4 (MFC)
- Target
- Candida tropicalis
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VII, C. albicans MIC 8 mg/L.
- Measure
- MIC
- Value
- 8 other
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VII, C. albicans MFC 8 mg/L.
- Measure
- other
- Value
- 8 (MFC)
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VII, C. glabrata MIC 4 mg/L.
- Measure
- MIC
- Value
- 4 other
- Target
- Candida glabrata
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VII, C. glabrata MFC 4 mg/L.
- Measure
- other
- Value
- 4 (MFC)
- Target
- Candida glabrata
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VII, C. lipolytica MIC 4 mg/L.
- Measure
- MIC
- Value
- 4 other
- Target
- Candida lipolytica
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VII, C. lipolytica MFC 4 mg/L.
- Measure
- other
- Value
- 4 (MFC)
- Target
- Candida lipolytica
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VII, C. tropicalis MIC 8 mg/L.
- Measure
- MIC
- Value
- 8 other
- Target
- Candida tropicalis
- Assay
- Not reported by source
AntimicrobialAntifungalPositive observation
Record detail Table 2: Compound VII, C. tropicalis MFC 8 mg/L.
- Measure
- other
- Value
- 8 (MFC)
- Target
- Candida tropicalis
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmNegative / threshold
Record detail Table 3: Compound V, MBEC 24 h >512 mg/L.
- Measure
- other
- Value
- >512 (MBEC)
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmNegative / threshold
Record detail Table 3: Compound V, MBEC 48 h >512 mg/L.
- Measure
- other
- Value
- >512 (MBEC)
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmNegative / threshold
Record detail Table 3: Compound V, MBEC 72 h >512 mg/L.
- Measure
- other
- Value
- >512 (MBEC)
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmPositive observation
Record detail Table 3: Compound VI, MBEC 24 h 512 mg/L.
- Measure
- other
- Value
- 512 (MBEC)
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmNegative / threshold
Record detail Table 3: Compound VI, MBEC 48 h >512 mg/L.
- Measure
- other
- Value
- >512 (MBEC)
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmNegative / threshold
Record detail Table 3: Compound VI, MBEC 72 h >512 mg/L.
- Measure
- other
- Value
- >512 (MBEC)
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmPositive observation
Record detail Table 3: Compound VII, MBEC 24 h 256 mg/L.
- Measure
- other
- Value
- 256 (MBEC)
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmPositive observation
Record detail Table 3: Compound VII, MBEC 48 h 256 mg/L.
- Measure
- other
- Value
- 256 (MBEC)
- Target
- Candida albicans
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmPositive observation
Record detail Table 3: Compound VII, MBEC 72 h 512 mg/L.
- Measure
- other
- Value
- 512 (MBEC)
- Target
- Candida albicans
- Assay
- Not reported by source
Toxicity 6 records
PMC11990879
6 observationsToxicityHemolyticNegative / threshold
Record detail Table 2: Compound II, MHC5% >256 mg/L.
- Measure
- other
- Value
- >256 (MHC5)
- Target
- Homo sapiens
- Assay
- Not reported by source
ToxicityHemolyticPositive observation
Record detail Table 2: Compound III, MHC5% 256 mg/L.
- Measure
- other
- Value
- 256 (MHC5)
- Target
- Homo sapiens
- Assay
- Not reported by source
ToxicityHemolyticPositive observation
Record detail Table 2: Compound IV, MHC5% 64 mg/L.
- Measure
- other
- Value
- 64 (MHC5)
- Target
- Homo sapiens
- Assay
- Not reported by source
ToxicityHemolyticPositive observation
Record detail Table 2: Compound V, MHC5% 4 mg/L.
- Measure
- other
- Value
- 4 (MHC5)
- Target
- Homo sapiens
- Assay
- Not reported by source
ToxicityHemolyticPositive observation
Record detail Table 2: Compound VI, MHC5% 4 mg/L.
- Measure
- other
- Value
- 4 (MHC5)
- Target
- Homo sapiens
- Assay
- Not reported by source
ToxicityHemolyticPositive observation
Record detail Table 2: Compound VII, MHC5% 4 mg/L.
- Measure
- other
- Value
- 4 (MHC5)
- Target
- Homo sapiens
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-000314, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00