ProForma 2.0
validated simple linear
APPERKYSVW
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-000181
P2
Aliases: P2
Normalized sequence
APPERKYSVW
10 amino acids
Release PepDiana-V1-20260620
1
Activity records
1
Source papers
1
Positive
0
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
1232.387 Da
Molecular formula
C58H85N15O15
Theoretical pI
8.6339
Net charge at pH 7
0.7967
GRAVY
-1.21
Instability index
64.9
Aromaticity
0.2
Topological polar surface area
489.11 Ų
cLogP
-2.6285
Hydrogen-bond donors
17
Hydrogen-bond acceptors
16
Rotatable bonds
34
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{A.P.P.E.R.K.Y.S.V.W}$$$$V2.0
Canonical SMILES
validated
CC(N)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CO)C(=O)NC(C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O)C(C)C
Isomeric SMILES
validated
CC(C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
Paper-level observations
Experimental evidence grouped by activity
Metabolic/Cardiovascular 1 records
PMC10001067
1 observationsMetabolic/CardiovascularXO InhibitorPositive observation
Record detail Table 3: XOI Activity of IC50 (mM) for APPERKYSVW is 5.86 ± 0.02. Text: 'AW10 (IC50 = 5.86 ± 0.02 mM)'.
- Measure
- other
- Value
- 5.86 ± 0.02 mM
- Target
- Bos taurus
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-000181, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00