ProForma 2.0
validated simple linear
AGPAGPAGPAGPR
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-000095
AGPAGPAGPAGPR
Aliases: AGPAGPAGPAGPR
Normalized sequence
AGPAGPAGPAGPR
13 amino acids
Release PepDiana-V1-20260620
2
Activity records
1
Source papers
2
Positive
0
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
1075.1786 Da
Molecular formula
C46H74N16O14
Theoretical pI
9.795
Net charge at pH 7
0.7959
GRAVY
-0.4077
Instability index
47.8769
Aromaticity
0
Topological polar surface area
439.26 Ų
cLogP
-6.8908
Hydrogen-bond donors
13
Hydrogen-bond acceptors
15
Rotatable bonds
25
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{A.G.P.A.G.P.A.G.P.A.G.P.R}$$$$V2.0
Canonical SMILES
validated
CC(N)C(=O)NCC(=O)N1CCCC1C(=O)NC(C)C(=O)NCC(=O)N1CCCC1C(=O)NC(C)C(=O)NCC(=O)N1CCCC1C(=O)NC(C)C(=O)NCC(=O)N1CCCC1C(=O)NC(CCCNC(=N)N)C(=O)O
Isomeric SMILES
validated
C[C@H](N)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Paper-level observations
Experimental evidence grouped by activity
Metabolic/Cardiovascular 2 records
PMC10001269
2 observationsMetabolic/CardiovascularACE InhibitorPositive observation
Record detail Table 3: ACE IC50 Seq5 (AGPAGPAGPAGPR) 11.7 ± 1.34 mM.
- Measure
- other
- Value
- 11.7 ± 1.34 other
- Target
- Oryctolagus cuniculus
- Assay
- Not reported by source
Metabolic/CardiovascularDPP-IV InhibitorPositive observation
Record detail Table 3: DPP-IV IC50 Seq5 (AGPAGPAGPAGPR) 4.56 ± 0.57 mM.
- Measure
- other
- Value
- 4.56 ± 0.57 other
- Target
- DPP-IV
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-000095, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00