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PEPDIA-INT-082502

Silver

Teduglutide

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

HGDGSFSDEMNTILDNLAARDFINWLIQTKITD

Indexed sequence33 aa

1HGDGSFSDEMNTILDNLAARDFINWLIQTKITD

Length

Molecular weight

3752.14 Da

Formula

C164H252N44O55S

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic13

Membrane affinity proxy

Polar9

Solubility proxy

Charged9

Net charge proxy -3

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

3752.082 Da

Molecular formula

C164H252N44O55S

Theoretical pI

4.3011

Net charge at pH 7

-4.1421

GRAVY

-0.3485

Instability index

5.5576

Aromaticity

0.0909

Topological polar surface area

1624.22 Å²

cLogP

-16.8852

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

125

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

HGDGSFSDEMNTILDNLAARDFINWLIQTKITD

HELM 2.0

validated simple linear

PEPTIDE1{H.G.D.G.S.F.S.D.E.M.N.T.I.L.D.N.L.A.A.R.D.F.I.N.W.L.I.Q.T.K.I.T.D}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CC(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(N)=O)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(NC(=O)C(CC(N)=O)NC(=O)C(CCSC)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(Cc1ccccc1)NC(=O)C(CO)NC(=O)CNC(=O)C(CC(=O)O)NC(=O)CNC(=O)C(N)Cc1c[nH]cn1)C(C)O)C(C)CC)C(=O)NC(CC(N)=O)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CCC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(C(=O)NC(CC(=O)O)C(=O)O)C(C)O)C(C)CC)C(C)O)C(C)CC

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-082502,
  title = {Teduglutide},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-082502},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Teduglutide. (2026). PepDiana record PEPDIA-INT-082502. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-082502

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (4 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P082502_ACT_peptherdia_0000	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	17peptherdia / linked
CTPDB_P082502_ACT_thpdb_0001	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1137_10652_rec0thpdb / unavailable
CTPDB_P082502_ACT_thpdb_0002	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1137_10653_rec1thpdb / unavailable
CTPDB_P082502_ACT_thpdb_0003	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1137_10654_rec2thpdb / unavailable

Provenance

Source database records (4)

peptherdia

Raw sequence

HGDGSFSDEMNTILDNLAARDFINWLIQTKITD

thpdb

Th1137_10652_rec0

Raw sequence

HGDGSFSDEMNTILDNLAARDFINWLIQTKITD

thpdb

Th1137_10653_rec1

Raw sequence

HGDGSFSDEMNTILDNLAARDFINWLIQTKITD

thpdb

Th1137_10654_rec2

Raw sequence

HGDGSFSDEMNTILDNLAARDFINWLIQTKITD

Citation trail

Literature (1 records)

[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB08900", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB08900)"}, {"text": "fda.gov", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203441Orig1s002.pdf", "markdown": "[fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203441Orig1s002.pdf)"}, {"text": "europa.eu", "url": "https://www.ema.europa.eu/en/documents/assessment-report/revestive-epar-public-assessment-report_en.pdf", "markdown":

[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB08900", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB08900)"}, {"text": "fda.gov", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203441Orig1s002.pdf", "markdown": "[fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/203441Orig1s002.pdf)"}, {"text": "europa.eu", "url": "https://www.ema.europa.eu/en/documents/assessment-report/revestive-epar-public-assessment-report_en.pdf", "markdown":

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:21.345173+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "source_db": "thpdb",
      "assay_method": "The most common adverse reactions (= 10%) across all studies with GATTEX are abdominal pain, injection site reactions, nausea, headaches, abdominal distension, upper respiratory tract infection. In ad",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "The most common adverse reactions (= 10%) across all studies with GATTEX are abdominal pain, injection site reactions, nausea, headaches, abdominal distension, upper respiratory tract infection. In ad",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "The most common adverse reactions (= 10%) across all studies with GATTEX are abdominal pain, injection site reactions, nausea, headaches, abdominal distension, upper respiratory tract infection. In ad",
      "toxicity_type": "Toxicity"
    }
  ]
}

Source metadata

[
  {
    "source_db": "peptherdia",
    "organism_name": "Unknown"
  },
  {
    "source_db": "thpdb",
    "organism_name": "Unknown"
  }
]

Clinical trials

[
  {
    "status": "Therapeutic",
    "drug_name": "Teduglutide",
    "source_db": "peptherdia",
    "indication": "Treatment of short bowel syndrome (SBS), malabsorption associated with the removal of the intestine, in adults patients who are dependent on parenteral support.",
    "approval_year": 2012,
    "approval_agency": "FDA",
    "administration_route": "SC"
  }
]

Approved drug annotations

{
  "status": "Therapeutic",
  "drug_name": "Teduglutide",
  "source_db": "peptherdia",
  "indication": "Treatment of short bowel syndrome (SBS), malabsorption associated with the removal of the intestine, in adults patients who are dependent on parenteral support.",
  "approval_year": 2012,
  "approval_agency": "FDA",
  "administration_route": "SC"
}