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PEPDIA-INT-081832

Gold

Ixosin-B (22-32) [S23W,D24L,V25R,R27V,S30W,R31W,Y32R]

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

KWLRRVWRWWR

Indexed sequence11 aa

1KWLRRVWRWWR

Length

Molecular weight

1728.10 Da

Formula

C85H122N28O12

Structure type

Linear

Synthesis

Synthetic

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic6

Membrane affinity proxy

Polar0

Solubility proxy

Charged5

Net charge proxy +5

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1728.0586 Da

Molecular formula

C85H122N28O12

Theoretical pI

Net charge at pH 7

4.7591

GRAVY

-1.5909

Instability index

141.9636

Aromaticity

0.3636

Topological polar surface area

691.1 Å²

cLogP

0.0265

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

KWLRRVWRWWR

HELM 2.0

validated simple linear

PEPTIDE1{K.W.L.R.R.V.W.R.W.W.R}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(N)CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCNC(=N)N)C(=O)O)C(C)C

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-081832,
  title = {Ixosin-B (22-32) [S23W,D24L,V25R,R27V,S30W,R31W,Y32R]},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-081832},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Ixosin-B (22-32) [S23W,D24L,V25R,R27V,S30W,R31W,Y32R]. (2026). PepDiana record PEPDIA-INT-081832. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-081832

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (36 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P081832_ACT_camp_0000	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ10331camp / linked
CTPDB_P081832_ACT_camp_0001	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ10331camp / linked
CTPDB_P081832_ACT_cancerppd_0002	Anticancer	Anticancer	Not available in the current structured import	Unknown	MTT/MTS assay	3114cancerppd / linked
CTPDB_P081832_ACT_cancerppd_0003	Antimicrobial	-	Not available in the current structured import	Unknown	MTT/MTS assay	3114cancerppd / linked
CTPDB_P081832_ACT_cancerppd_0004	Anticancer	Anticancer	Not available in the current structured import	Unknown	MTT/MTS assay	3115cancerppd / linked
CTPDB_P081832_ACT_cancerppd_0005	Antimicrobial	-	Not available in the current structured import	Unknown	MTT/MTS assay	3115cancerppd / linked
CTPDB_P081832_ACT_cancerppd_0006	Anticancer	Anticancer	Not available in the current structured import	Unknown	MTT/MTS assay	3116cancerppd / linked
CTPDB_P081832_ACT_cancerppd_0007	Antimicrobial	-	Not available in the current structured import	Unknown	MTT/MTS assay	3116cancerppd / linked
CTPDB_P081832_ACT_cancerppd_0008	Anticancer	Anticancer	Not available in the current structured import	Unknown	MTT/MTS assay	3117cancerppd / linked
CTPDB_P081832_ACT_cancerppd_0009	Antimicrobial	-	Not available in the current structured import	Unknown	MTT/MTS assay	3117cancerppd / linked
CTPDB_P081832_ACT_cancerppd_0010	Anticancer	Anticancer	Not available in the current structured import	Unknown	MTT/MTS assay	3118cancerppd / linked
CTPDB_P081832_ACT_cancerppd_0011	Antimicrobial	-	Not available in the current structured import	Unknown	MTT/MTS assay	3118cancerppd / linked
CTPDB_P081832_ACT_cancerppd_0012	Anticancer	Anticancer	Not available in the current structured import	Unknown	MTT/MTS assay	3122cancerppd / linked
CTPDB_P081832_ACT_cancerppd_0013	Antimicrobial	-	Not available in the current structured import	Unknown	MTT/MTS assay	3122cancerppd / linked
CTPDB_P081832_ACT_dbaasp_0014	Antimicrobial	-	15 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_4584_chain0dbaasp / linked
CTPDB_P081832_ACT_dbaasp_0015	Antimicrobial	-	2.5 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_4584_chain0dbaasp / linked
CTPDB_P081832_ACT_dbaasp_0016	Antimicrobial	-	20 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_4584_chain0dbaasp / linked
CTPDB_P081832_ACT_dbaasp_0017	Antimicrobial	-	61.5 µM	Human breast adenocarcinoma MCF-7	Not reported by source	DBAASPS_4584_chain0dbaasp / linked
CTPDB_P081832_ACT_dbaasp_0018	Antimicrobial	-	>100 µM	Candida albicans ATCC 64550	Not reported by source	DBAASPS_4584_chain0dbaasp / linked
CTPDB_P081832_ACT_dbaasp_0019	Antimicrobial	-	5 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_4584_chain0dbaasp / linked
CTPDB_P081832_ACT_dbaasp_0020	Antimicrobial	-	5 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_4584_chain0dbaasp / linked
CTPDB_P081832_ACT_dbaasp_0021	Antimicrobial	-	5 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_4584_chain0dbaasp / linked
CTPDB_P081832_ACT_dbaasp_0022	Antimicrobial	-	5 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_9744_chain0dbaasp / linked
CTPDB_P081832_ACT_dbaasp_0023	Antimicrobial	-	5 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_9744_chain0dbaasp / linked
CTPDB_P081832_ACT_dbaasp_0024	Antimicrobial	-	5 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_9744_chain0dbaasp / linked
CTPDB_P081832_ACT_dbaasp_0025	Antimicrobial	-	10 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_9744_chain0dbaasp / linked
CTPDB_P081832_ACT_dbaasp_0026	Antimicrobial	-	5 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_9744_chain0dbaasp / linked
CTPDB_P081832_ACT_dbaasp_0027	Antimicrobial	-	5 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_9744_chain0dbaasp / linked
CTPDB_P081832_ACT_dramp_0028	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP18564dramp / linked
CTPDB_P081832_ACT_dramp_0029	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP18564dramp / linked
CTPDB_P081832_ACT_dramp_0030	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP18564dramp / linked
CTPDB_P081832_ACT_dramp_0031	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP18564dramp / linked
CTPDB_P081832_ACT_hemolytik_0032	Toxicity	Hemolytic	100.0 µM	Erythrocytes	Not reported by source	2767hemolytik / linked
CTPDB_P081832_ACT_satpdb_0033	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	satpdb13727satpdb / linked
CTPDB_P081832_ACT_satpdb_0034	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb13727satpdb / linked
CTPDB_P081832_ACT_satpdb_0035	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb13727satpdb / linked

Provenance

Source database records (12)

camp

CAMPSQ10331

Raw sequence

KWLRRVWRWWR

cancerppd

3114

Raw sequence

KWLRRVWRWWR

cancerppd

3115

Raw sequence

KWLRRVWRWWR

cancerppd

3116

Raw sequence

KWLRRVWRWWR

cancerppd

3117

Raw sequence

KWLRRVWRWWR

cancerppd

3118

Raw sequence

KWLRRVWRWWR

cancerppd

3122

Raw sequence

KWLRRVWRWWR

dbaasp

DBAASPS_4584_chain0

Raw sequence

KWLRRVWRWWR

dbaasp

DBAASPS_9744_chain0

Raw sequence

KWLRRVWRWWR

dramp

DRAMP18564

Raw sequence

KWLRRVWRWWR

hemolytik

2767

Raw sequence

KWLRRVWRWWR

satpdb

satpdb13727

Raw sequence

KWLRRVWRWWR

Citation trail

Literature (5 records)

-

--PMID 22578463

-

--PMID 23993331

Discovery of potent antimicrobial peptide analogs of Ixosin-B.

Lung FD, Wang KS, Liao ZJ, Hsu SK, Song FY, Liou CC, Wu YS

Bioorg Med Chem Lett2012PMID 28105725

Discovery of potent antimicrobial peptide analogs of Ixosin-B.

Lung FD, Wang KS, Liao ZJ, Hsu SK, Song FY, Liou CC, Wu YS

Bioorg Med Chem Lett2012PMID 31059203

[{"citation": "", "authors": [{"name": "Lung FD", "description": ""}], "journal": {"name": "Patent US 20160130301 A1", "description": ""}, "year": 2016, "volume": "", "pages": "1-9", "title": "NOVEL PEPTIDE AND USES THEREOF", "pubmed_id": "", "pubmed_link": ""}]

[{"citation": "", "authors": [{"name": "Lung FD", "description": ""}], "journal": {"name": "Patent US 20160130301 A1", "description": ""}, "year": 2016, "volume": "", "pages": "1-9", "title": "NOVEL PEPTIDE AND USES THEREOF", "pubmed_id": "", "pubmed_link": ""}]

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:14.859692+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "100",
      "source_db": "dbaasp",
      "assay_method": "100% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "100",
      "source_db": "dbaasp",
      "assay_method": "70.7% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "100",
      "source_db": "dbaasp",
      "assay_method": "71% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.22578463]100% hemolysis at 100μM against human red blood cells",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cancerppd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CGGGGGGGTTC"
}