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PEPDIA-INT-081204

Silver

SLAY-screened peptide P2380

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

Indexed sequence2 aa

1SL

Length

Molecular weight

218.25 Da

Formula

C9H18N2O4

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic1

Membrane affinity proxy

Polar1

Solubility proxy

Charged0

Net charge proxy +0

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

218.2502 Da

Molecular formula

C9H18N2O4

Theoretical pI

5.24

Net charge at pH 7

-0.5399

GRAVY

1.5

Instability index

Aromaticity

Topological polar surface area

112.65 Å²

cLogP

-1.0785

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

HELM 2.0

validated simple linear

PEPTIDE1{S.L}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(N)CO)C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@@H](N)CO)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-081204,
  title = {SLAY-screened peptide P2380},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-081204},
  note = {Accessed from local PepDiana development build}
}

APA-style note

SLAY-screened peptide P2380. (2026). PepDiana record PEPDIA-INT-081204. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-081204

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (4 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P081204_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	Not available in the current structured import	Unknown	Not reported by source	3884ahtpdb / linked
CTPDB_P081204_ACT_dramp_0001	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP24030dramp / linked
CTPDB_P081204_ACT_dramp_0002	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP25357dramp / linked
CTPDB_P081204_ACT_satpdb_0003	Metabolic/Cardiovascular	Antihypertensive	Not available in the current structured import	Unknown	Not reported by source	satpdb20026satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-004048 View all experimental records

Provenance

Source database records (4)

ahtpdb

3884

Raw sequence

dramp

DRAMP24030

Raw sequence

dramp

DRAMP25357

Raw sequence

satpdb

satpdb20026

Raw sequence

Citation trail

Literature (2 records)

Three-dimensional holograph vector of atomic interaction field (3D-HoVAIF): a novel rotation-translation invariant 3D structure descriptor and its applications to peptides.

Tian F1, Zhou P, Lv F, Song R, Li Z.

J Pept Sci. 2007 Aug;13(8):549-66.2007PMID 17654623

Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries

Ashley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies

Cell2018PMID 29307492

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.254051+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CC"
}