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PEPDIA-INT-077906

Silver

Cyclopeptide 1 (natural AMPs; sea sponge, marine animals, XXC; UCBB)

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

GSPE

Indexed sequence4 aa

1GSPE

Length

Molecular weight

388.38 Da

Formula

C15H24N4O8

Structure type

Linear

Synthesis

Non-ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic0

Membrane affinity proxy

Polar1

Solubility proxy

Charged1

Net charge proxy -1

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

388.3731 Da

Molecular formula

C15H24N4O8

Theoretical pI

4.5989

Net charge at pH 7

-1.2319

GRAVY

-1.575

Instability index

160.8

Aromaticity

Topological polar surface area

199.36 Å²

cLogP

-3.1526

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

GSPE

HELM 2.0

validated simple linear

PEPTIDE1{G.S.P.E}$$$$V2.0

Canonical SMILES

validated

NCC(=O)NC(CO)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)O

Isomeric SMILES

validated

NCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-077906,
  title = {Cyclopeptide 1 (natural AMPs; sea sponge, marine animals, XXC; UCBB)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-077906},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Cyclopeptide 1 (natural AMPs; sea sponge, marine animals, XXC; UCBB). (2026). PepDiana record PEPDIA-INT-077906. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-077906

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (13 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P077906_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP03255apd / linked
CTPDB_P077906_ACT_camp_0001	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ22946camp / linked
CTPDB_P077906_ACT_camp_0002	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ22946camp / linked
CTPDB_P077906_ACT_camp_0003	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ22946camp / linked
CTPDB_P077906_ACT_dbaasp_0004	Antimicrobial	-	25 µg/ml	Bacillus subtilis subsp. spizizenii DSM 347	Not reported by source	DBAASPS_10055_chain0dbaasp / linked
CTPDB_P077906_ACT_dbaasp_0005	Antimicrobial	-	NA	Escherichia coli DSM 498	Not reported by source	DBAASPS_10055_chain0dbaasp / linked
CTPDB_P077906_ACT_dbaasp_0006	Antimicrobial	-	NA	Saccharomyces cerevisiae DSM 70449	Not reported by source	DBAASPS_10055_chain0dbaasp / linked
CTPDB_P077906_ACT_dbaasp_0007	Antimicrobial	-	NA	Pseudomonas aeruginosa	Not reported by source	DBAASPS_10055_chain0dbaasp / linked
CTPDB_P077906_ACT_dbaasp_0008	Antimicrobial	-	NA	Staphylococcus aureus	Not reported by source	DBAASPS_10055_chain0dbaasp / linked
CTPDB_P077906_ACT_dbaasp_0009	Antimicrobial	-	NA	Human prostate adenocarcinoma LNCaP	Not reported by source	DBAASPS_10055_chain0dbaasp / linked
CTPDB_P077906_ACT_dbaasp_0010	Antimicrobial	-	NA	Human hepatocellular carcinoma HepG2	Not reported by source	DBAASPS_10055_chain0dbaasp / linked
CTPDB_P077906_ACT_dramp_0011	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP34412dramp / linked
CTPDB_P077906_ACT_dramp_0012	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP34412dramp / linked

Provenance

Source database records (4)

apd

AP03255

Raw sequence

GSPE

camp

CAMPSQ22946

Raw sequence

GSPE

dbaasp

DBAASPS_10055_chain0

Raw sequence

GSPE

dramp

DRAMP34412

Raw sequence

GSPE

Citation trail

Literature (2 records)

Cyclic peptides from a Ruegeria strain of bacteria associated with the sponge Suberites domuncula

Mitova M, Popov S, De Rosa S. 2004

J Nat Prod2004PMID 15270577

-

--PMID 25988520

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.715308+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  }
]