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PEPDIA-INT-075943

Gold

Glucagon

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

Indexed sequence29 aa

1HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

Length

Molecular weight

3482.80 Da

Formula

C153H225N43O49S

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic10

Membrane affinity proxy

Polar11

Solubility proxy

Charged7

Net charge proxy +1

Aromatic6

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

3482.7469 Da

Molecular formula

C153H225N43O49S

Theoretical pI

6.7485

Net charge at pH 7

-0.1524

GRAVY

-0.9897

Instability index

56.0276

Aromaticity

0.1724

Topological polar surface area

1538.74 Å²

cLogP

-17.9398

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

113

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

HELM 2.0

validated simple linear

PEPTIDE1{H.S.Q.G.T.F.T.S.D.Y.S.K.Y.L.D.S.R.R.A.Q.D.F.V.Q.W.L.M.N.T}$$$$V2.0

Canonical SMILES

validated

CSCCC(NC(=O)C(CC(C)C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCC(N)=O)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CC(=O)O)NC(=O)C(CCC(N)=O)NC(=O)C(C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CCC(N)=O)NC(=O)C(CO)NC(=O)C(N)Cc1c[nH]cn1)C(C)O)C(C)O)C(C)C)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)O)C(C)O

Isomeric SMILES

validated

CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)O)[C@@H](C)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-075943,
  title = {Glucagon},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-075943},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Glucagon. (2026). PepDiana record PEPDIA-INT-075943. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-075943

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (37 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P075943_ACT_peptherdia_0000	Clinical / Approved Drug	Dual-Role (Theranostic)	Not available in the current structured import	Unknown	Not reported by source	18peptherdia / linked
CTPDB_P075943_ACT_satpdb_0001	Bioregulatory	Cell-Cell Communication	Not available in the current structured import	Unknown	Not reported by source	satpdb25632satpdb / linked
CTPDB_P075943_ACT_thpdb_0002	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1035_10252_rec0thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0003	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1035_10253_rec1thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0004	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1035_10254_rec2thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0005	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1035_10255_rec3thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0006	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1035_10256_rec4thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0007	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11405_rec0thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0008	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11406_rec1thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0009	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11407_rec2thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0010	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11408_rec3thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0011	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11409_rec4thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0012	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11410_rec5thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0013	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11411_rec6thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0014	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11412_rec7thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0015	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11413_rec8thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0016	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11414_rec9thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0017	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11415_rec10thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0018	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11416_rec11thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0019	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11417_rec12thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0020	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11418_rec13thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0021	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11419_rec14thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0022	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11420_rec15thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0023	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11421_rec16thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0024	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11422_rec17thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0025	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11423_rec18thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0026	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11424_rec19thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0027	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11425_rec20thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0028	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11426_rec21thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0029	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11427_rec22thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0030	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11428_rec23thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0031	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11429_rec24thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0032	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11430_rec25thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0033	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11431_rec26thpdb / unavailable
CTPDB_P075943_ACT_thpdb_0034	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1247_11432_rec27thpdb / unavailable
CTPDB_P075943_ACT_topicalpdb_0035	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Osmolarity measurements: t=0 min., Glucagon/Buffer=311/312.5mOsm/l; t=6 min., Glucagon/Buffer=304/306.5mOsm/l; t=16 min., Glucagon/Buffer=305/307.5mOsm/l; Tear film osmolarity; in vivo	1431topicalpdb / linked
CTPDB_P075943_ACT_topicalpdb_0036	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Osmolarity measurements: t=0 min., Glucagon/Buffer=310/308mOsm/l; t=6 min., Glucagon/Buffer=301/306mOsm/l; t=16 min., Glucagon/Buffer=305/307mOsm/l; Volume measurement: Glucagon/Buffer= 11.5µl/5.2µl; Osmolarity and tear volume measurements; in vivo	1432topicalpdb / linked

Provenance

Source database records (37)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

peptherdia

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

satpdb

satpdb25632

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1035_10252_rec0

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1035_10253_rec1

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1035_10254_rec2

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1035_10255_rec3

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1035_10256_rec4

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11405_rec0

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11406_rec1

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11407_rec2

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11408_rec3

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11409_rec4

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11410_rec5

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11411_rec6

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11412_rec7

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11413_rec8

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11414_rec9

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11415_rec10

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11416_rec11

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11417_rec12

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11418_rec13

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11419_rec14

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11420_rec15

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11421_rec16

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11422_rec17

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11423_rec18

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11424_rec19

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11425_rec20

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11426_rec21

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11427_rec22

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11428_rec23

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11429_rec24

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11430_rec25

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11431_rec26

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

thpdb

Th1247_11432_rec27

Raw sequence

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

topicalpdb

1431

Raw sequence

HSQGTFTSDYSKYLD SRRAQDFVQWLMNT

topicalpdb

1432

Raw sequence

HSQGTFTSDYSKYLD SRRAQDFVQWLMNT

Citation trail

Literature (2 records)

[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB00040", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB00040)"}, {"text": "fda.gov", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/020918_S003_GLUCAGEN.pdf", "markdown": "[fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/020918_S003_GLUCAGEN.pdf)"}]

[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB00040", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB00040)"}, {"text": "fda.gov", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/020918_S003_GLUCAGEN.pdf", "markdown": "[fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/020918_S003_GLUCAGEN.pdf)"}]

-

--PMID 2365569

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:21.345173+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "source_db": "thpdb",
      "assay_method": "atients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium. Phentolamine may be given t",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "atients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium. Phentolamine may be given t",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "atients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium. Phentolamine may be given t",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "atients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium. Phentolamine may be given t",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "atients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium. Phentolamine may be given t",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Patients experiencing an overdose may present with nausea, vomiting, inhibition of GI tract motility, increased blood pressure and heart rate, and decreased serum potassium.[L7634,L7637,L7640,L7643] P",
      "toxicity_type": "Toxicity"
    }
  ]
}

Source metadata

[
  {
    "source_db": "peptherdia",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "thpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "topicalpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSCSCHHHHTTTHHHHHHHHHHTTSCCC"
}

Clinical trials

[
  {
    "status": "Diagnostic, Therapeutic",
    "drug_name": "Glucagon",
    "source_db": "peptherdia",
    "indication": "Indicated as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia",
    "approval_year": 1960,
    "approval_agency": "FDA",
    "administration_route": "NASAL, IV, IM, SC"
  }
]

Approved drug annotations

{
  "status": "Diagnostic, Therapeutic",
  "drug_name": "Glucagon",
  "source_db": "peptherdia",
  "indication": "Indicated as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia",
  "approval_year": 1960,
  "approval_agency": "FDA",
  "administration_route": "NASAL, IV, IM, SC"
}