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PEPDIA-INT-075806

Gold

Nesiritide

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH

Indexed sequence32 aa

1SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH

Length

Molecular weight

Formula

Structure type

Cyclic

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic8

Membrane affinity proxy

Polar9

Solubility proxy

Charged9

Net charge proxy +7

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

partial sequence only structural context

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

3466.0528 Da

Molecular formula

Not calculated

Theoretical pI

10.9482

Net charge at pH 7

5.5256

GRAVY

-0.5062

Instability index

86.7781

Aromaticity

0.0313

Topological polar surface area

Not calculated

cLogP

Not calculated

Hydrogen-bond donors

Not calculated

Hydrogen-bond acceptors

Not calculated

Rotatable bonds

Not calculated

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

not generated modification context

Not calculated for this record

HELM 2.0

not generated modification context

Not calculated for this record

Canonical SMILES

not generated modification context

Not calculated for this record

Isomeric SMILES

not generated modification context

Not calculated for this record

Follow-up research

External analysis tools

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Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-075806,
  title = {Nesiritide},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-075806},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Nesiritide. (2026). PepDiana record PEPDIA-INT-075806. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-075806

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (3 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P075806_ACT_peptherdia_0000	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	15peptherdia / linked
CTPDB_P075806_ACT_satpdb_0001	Bioregulatory	Cell-Cell Communication	Not available in the current structured import	Unknown	Not reported by source	satpdb19511satpdb / linked
CTPDB_P075806_ACT_thpdb_0002	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1109_10557_rec0thpdb / unavailable

Provenance

Source database records (3)

peptherdia

Raw sequence

SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH

satpdb

satpdb19511

Raw sequence

SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH

thpdb

Th1109_10557_rec0

Raw sequence

SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH

Citation trail

Literature (1 records)

[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB04899", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB04899)"}, {"text": "cvpharmacology.com", "url": "https://cvpharmacology.com/diuretic/natriuretics", "markdown": "[cvpharmacology.com](https://cvpharmacology.com/diuretic/natriuretics)"}, {"text": "fda.gov", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/020920s012lbl.pdf", "markdown": "[fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/lab

[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB04899", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB04899)"}, {"text": "cvpharmacology.com", "url": "https://cvpharmacology.com/diuretic/natriuretics", "markdown": "[cvpharmacology.com](https://cvpharmacology.com/diuretic/natriuretics)"}, {"text": "fda.gov", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/020920s012lbl.pdf", "markdown": "[fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/lab

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:21.345173+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "source_db": "thpdb",
      "assay_method": "No data are available with respect to overdosage in humans. The expected reaction would be excessive hypotension, which should be treated with drug discontinuation or reduction and appropriate measure",
      "toxicity_type": "Toxicity"
    }
  ]
}

Source metadata

[
  {
    "source_db": "peptherdia",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "thpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSSCCSSCSSCSCCCSTTSCCCSSCCCCCCC"
}

Clinical trials

[
  {
    "status": "Therapeutic",
    "drug_name": "Nesiritide",
    "source_db": "peptherdia",
    "indication": "Treatment of acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion",
    "approval_year": 2001,
    "approval_agency": "FDA",
    "administration_route": "IV"
  }
]

Approved drug annotations

{
  "status": "Therapeutic",
  "drug_name": "Nesiritide",
  "source_db": "peptherdia",
  "indication": "Treatment of acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion",
  "approval_year": 2001,
  "approval_agency": "FDA",
  "administration_route": "IV"
}