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PEPDIA-INT-074231

Gold

Violacin A (natural AMPs; uncyclo-tides, UCSS1a; 3S=S, plants)

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

SAISCGETCFKFKCYTPRCSCSYPVCK

Indexed sequence27 aa

1SAISCGETCFKFKCYTPRCSCSYPVCK

Length

Molecular weight

Formula

Structure type

Cyclic

Synthesis

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic7

Membrane affinity proxy

Polar12

Solubility proxy

Charged5

Net charge proxy +3

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

partial sequence only structural context

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

3012.5485 Da

Molecular formula

Not calculated

Theoretical pI

8.636

Net charge at pH 7

2.3985

GRAVY

0.0222

Instability index

25.6185

Aromaticity

0.1481

Topological polar surface area

Not calculated

cLogP

Not calculated

Hydrogen-bond donors

Not calculated

Hydrogen-bond acceptors

Not calculated

Rotatable bonds

Not calculated

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

not generated modification context

Not calculated for this record

HELM 2.0

not generated modification context

Not calculated for this record

Canonical SMILES

not generated modification context

Not calculated for this record

Isomeric SMILES

not generated modification context

Not calculated for this record

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-074231,
  title = {Violacin A (natural AMPs; uncyclo-tides, UCSS1a; 3S=S, plants)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-074231},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Violacin A (natural AMPs; uncyclo-tides, UCSS1a; 3S=S, plants). (2026). PepDiana record PEPDIA-INT-074231. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-074231

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (12 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P074231_ACT_apd_0000	Toxicity	Hemolytic	Not available in the current structured import	Unknown	Not reported by source	AP01135apd / linked
CTPDB_P074231_ACT_camp_0001	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3066camp / linked
CTPDB_P074231_ACT_dramp_0002	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP00926dramp / linked
CTPDB_P074231_ACT_hemolytik_0003	Toxicity	Hemolytic	1.5 µM	Erythrocytes	Not reported by source	3996hemolytik / linked
CTPDB_P074231_ACT_plantpepdb_0004	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	PPepDB_1572plantpepdb / linked
CTPDB_P074231_ACT_plantpepdb_0005	Enzyme Inhibitor	General Enzyme Inhibitor	Not available in the current structured import	Unknown	Not reported by source	PPepDB_1572plantpepdb / linked
CTPDB_P074231_ACT_plantpepdb_0006	Toxicity	Hemolytic	Not available in the current structured import	Unknown	Not reported by source	PPepDB_1572plantpepdb / linked
CTPDB_P074231_ACT_satpdb_0007	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb13102satpdb / linked
CTPDB_P074231_ACT_satpdb_0008	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb13102satpdb / linked
CTPDB_P074231_ACT_satpdb_0009	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb13102satpdb / linked
CTPDB_P074231_ACT_satpdb_0010	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb24260satpdb / linked
CTPDB_P074231_ACT_satpdb_0011	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb24260satpdb / linked

Provenance

Source database records (7)

apd

AP01135

Raw sequence

SAISCGETCFKFKCYTPRCSCSYPVCK

camp

CAMPSQ3066

Raw sequence

SAISCGETCFKFKCYTPRCSCSYPVCK

dramp

DRAMP00926

Raw sequence

SAISCGETCFKFKCYTPRCSCSYPVCK

hemolytik

3996

Raw sequence

SAISCGETCFKFKCYTPRCSCSYPVCK

plantpepdb

PPepDB_1572

Raw sequence

SAISCGETCFKFKCYTPRCSCSYPVCK

satpdb

satpdb13102

Raw sequence

SAISCGETCFKFKCYTPRCSCSYPVCK

satpdb

satpdb24260

Raw sequence

SAISCGETCFKFKCYTPRCSCSYPVCK

Citation trail

Literature (3 records)

{"reference": "J Mol Biol. 2006 Apr 14;357(5):1522-35", "title": "Discovery and characterization of a linear cyclotide from Viola odorata: implications for the processing of circular proteins.", "author": "Ireland DC, Colgrave ML, Nguyencong P, Daly NL, Craik DJ.2006"}

{"reference": "J Mol Biol. 2006 Apr 14;357(5):1522-35", "title": "Discovery and characterization of a linear cyclotide from Viola odorata: implications for the processing of circular proteins.", "author": "Ireland DC, Colgrave ML, Nguyencong P, Daly NL, Craik DJ.2006"}

-

--PMID 16488428

A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability..##Discovery and characterization of a linear cyclotide from Viola odorata: implications for the processing of circular proteins.

Ireland DC, Colgrave ML, Craik DJ.##Ireland DC, Colgrave ML, Nguyencong P, Daly NL, Craik DJ.

Biochem J2006PMID 16872274

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.491115+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref:16488428]10% hemolytic activity at 1.0μM and 35% hemolytic activity at 1.5μM against human type A red blood cells",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "pdb_id": "2FQA resolved by NMR.",
  "source_db": "dramp"
}