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PEPDIA-INT-072778

Gold

Omega-conotoxin MVIIA, Ziconotide

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

CKGKGAKCSRLMYDCCTGSCRSGKC

Indexed sequence25 aa

1CKGKGAKCSRLMYDCCTGSCRSGKC

Length

Molecular weight

2646.22 Da

Formula

C102H177N35O33S7

Structure type

Linear

Synthesis

Ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic4

Membrane affinity proxy

Polar10

Solubility proxy

Charged7

Net charge proxy +5

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

2646.1664 Da

Molecular formula

C102H177N35O33S7

Theoretical pI

9.1257

Net charge at pH 7

4.6968

GRAVY

-0.464

Instability index

59.528

Aromaticity

0.04

Topological polar surface area

1128.05 Å²

cLogP

-17.2198

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

CKGKGAKCSRLMYDCCTGSCRSGKC

HELM 2.0

validated simple linear

PEPTIDE1{C.K.G.K.G.A.K.C.S.R.L.M.Y.D.C.C.T.G.S.C.R.S.G.K.C}$$$$V2.0

Canonical SMILES

validated

CSCCC(NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(CS)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(N)CS)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CC(=O)O)C(=O)NC(CS)C(=O)NC(CS)C(=O)NC(C(=O)NCC(=O)NC(CO)C(=O)NC(CS)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CS)C(=O)O)C(C)O

Isomeric SMILES

validated

CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-072778,
  title = {Omega-conotoxin MVIIA, Ziconotide},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-072778},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Omega-conotoxin MVIIA, Ziconotide. (2026). PepDiana record PEPDIA-INT-072778. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-072778

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (15 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P072778_ACT_camp_0000	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ23613camp / linked
CTPDB_P072778_ACT_camp_0001	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ23613camp / linked
CTPDB_P072778_ACT_camp_0002	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ23613camp / linked
CTPDB_P072778_ACT_conoserver_0003	Neuroactive/Ion Channel	Toxin	Not available in the current structured import	Voltage-Gated Calcium Channels	Not reported by source	P01386conoserver / linked
CTPDB_P072778_ACT_conoserver_0004	Neuroactive/Ion Channel	Toxin	Not available in the current structured import	Voltage-Gated Calcium Channels	Not reported by source	P01386conoserver / linked
CTPDB_P072778_ACT_conoserver_0005	Neuroactive/Ion Channel	Toxin	Not available in the current structured import	Voltage-Gated Calcium Channels	Not reported by source	P01386conoserver / linked
CTPDB_P072778_ACT_conoserver_0006	Neuroactive/Ion Channel	Toxin	Not available in the current structured import	Voltage-Gated Calcium Channels	Not reported by source	P10845conoserver / linked
CTPDB_P072778_ACT_dbaasp_0007	Antimicrobial	-	>500 µM	Escherichia coli	Not reported by source	DBAASPS_13514_chain0dbaasp / linked
CTPDB_P072778_ACT_dbaasp_0008	Antimicrobial	-	>500 µM	Pseudomonas aeruginosa	Not reported by source	DBAASPS_13514_chain0dbaasp / linked
CTPDB_P072778_ACT_dbaasp_0009	Antimicrobial	-	>500 µM	Staphylococcus aureus	Not reported by source	DBAASPS_13514_chain0dbaasp / linked
CTPDB_P072778_ACT_dbaasp_0010	Antimicrobial	-	28.8 µM	Candida kefyr	Not reported by source	DBAASPS_13514_chain0dbaasp / linked
CTPDB_P072778_ACT_dbaasp_0011	Antimicrobial	-	39.8 µM	Candida tropicalis	Not reported by source	DBAASPS_13514_chain0dbaasp / linked
CTPDB_P072778_ACT_satpdb_0012	Unknown	miscellaneous	Not available in the current structured import	Unknown	Not reported by source	satpdb13347satpdb / linked
CTPDB_P072778_ACT_satpdb_0013	Unknown	miscellaneous	Not available in the current structured import	Unknown	Not reported by source	satpdb17028satpdb / linked
CTPDB_P072778_ACT_satpdb_0014	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb28098satpdb / linked

Provenance

Source database records (15)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

b3pdb

b3pdb_1088

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC

b3pdb

b3pdb_1089

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC

b3pdb

b3pdb_1090

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC

b3pdb

b3pdb_1091

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC

b3pdb

b3pdb_0042

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC

camp

CAMPSQ23613

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC

conoserver

P01386

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC(nh2)

conoserver

P01841

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC

conoserver

P01868

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC

conoserver

P02269

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC

conoserver

P10845

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC

dbaasp

DBAASPS_13514_chain0

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC

satpdb

satpdb13347

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC

satpdb

satpdb17028

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC

satpdb

satpdb28098

Raw sequence

CKGKGAKCSRLMYDCCTGSCRSGKC

Citation trail

Literature (25 records)

[{"full_text": "Drinkwater,R.D., Lewis,R.J., Alewood,P.F. and Nielsen,K.J. (2006) Omega.conotoxin peptidesPatent: US 7101849 05-SEP-2006", "authors": "Drinkwater,R.D., Lewis,R.J., Alewood,P.F. and Nielsen,K.J.", "year": "2006", "title": "Omega.conotoxin peptidesPatent: US 7101849 05-SEP-2006", "journal": "", "url": null, "pmid": null}]

[{"full_text": "Drinkwater,R.D., Lewis,R.J., Alewood,P.F. and Nielsen,K.J. (2006) Omega.conotoxin peptidesPatent: US 7101849 05-SEP-2006", "authors": "Drinkwater,R.D., Lewis,R.J., Alewood,P.F. and Nielsen,K.J.", "year": "2006", "title": "Omega.conotoxin peptidesPatent: US 7101849 05-SEP-2006", "journal": "", "url": null, "pmid": null}]

[{"full_text": "Craik,D.J., Daly,N.L. and Nielsen,K.J. (2006) Cyclized conotoxin peptidesPatent: US 7001883-A 29 21-FEB-2006; The University of Queensland; Queensland; AU;", "authors": "Craik,D.J., Daly,N.L. and Nielsen,K.J.", "year": "2006", "title": "Cyclized conotoxin peptidesPatent: US 7001883-A 29 21-FEB-2006; The University of Queensland; Queensland; AU;", "journal": "", "url": null, "pmid": null}]

[{"full_text": "Craik,D.J., Daly,N.L. and Nielsen,K.J. (2006) Cyclized conotoxin peptidesPatent: US 7001883-A 29 21-FEB-2006; The University of Queensland; Queensland; AU;", "authors": "Craik,D.J., Daly,N.L. and Nielsen,K.J.", "year": "2006", "title": "Cyclized conotoxin peptidesPatent: US 7001883-A 29 21-FEB-2006; The University of Queensland; Queensland; AU;", "journal": "", "url": null, "pmid": null}]

[{"full_text": "Pang,I.-H., Kapin,M. and Hellberg,M. (1999) Use of .omega.-conotoxin analogs for treating retinal and optic nerve head damagePatent: US 5965534-A 7 12-OCT-1999;", "authors": "Pang,I.-H., Kapin,M. and Hellberg,M.", "year": "1999", "title": "Use of .omega.-conotoxin analogs for treating retinal and optic nerve head damagePatent: US 5965534-A 7 12-OCT-1999;", "journal": "", "url": null, "pmid": null}]

[{"full_text": "Pang,I.-H., Kapin,M. and Hellberg,M. (1999) Use of .omega.-conotoxin analogs for treating retinal and optic nerve head damagePatent: US 5965534-A 7 12-OCT-1999;", "authors": "Pang,I.-H., Kapin,M. and Hellberg,M.", "year": "1999", "title": "Use of .omega.-conotoxin analogs for treating retinal and optic nerve head damagePatent: US 5965534-A 7 12-OCT-1999;", "journal": "", "url": null, "pmid": null}]

-

--PMID 37148162

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:13.602083+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "4230",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "b3pdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "conoserver",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CBCTTSCCCSSSCCBSSSCCBTTBC"
}