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PEPDIA-INT-072553

Gold

M6 (Synthetic AMPs, dendrimeric peptides; BBMm; BBN)

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

QKKIRVRLSA

Indexed sequence10 aa

1QKKIRVRLSA

Length

Molecular weight

1198.48 Da

Formula

C52H99N19O13

Structure type

Linear

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic4

Membrane affinity proxy

Polar2

Solubility proxy

Charged4

Net charge proxy +4

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1198.4619 Da

Molecular formula

C52H99N19O13

Theoretical pI

Net charge at pH 7

3.7581

GRAVY

-0.68

Instability index

0.51

Aromaticity

Topological polar surface area

564.38 Å²

cLogP

-5.4281

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

QKKIRVRLSA

HELM 2.0

validated simple linear

PEPTIDE1{Q.K.K.I.R.V.R.L.S.A}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C)C(=O)O)C(C)C

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)O)C(C)C

Follow-up research

External analysis tools

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-072553,
  title = {M6 (Synthetic AMPs, dendrimeric peptides; BBMm; BBN)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-072553},
  note = {Accessed from local PepDiana development build}
}

APA-style note

M6 (Synthetic AMPs, dendrimeric peptides; BBMm; BBN). (2026). PepDiana record PEPDIA-INT-072553. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-072553

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (34 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P072553_ACT_apd_0000	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	AP04474apd / linked
CTPDB_P072553_ACT_avpdb_0001	Antiviral	General Antiviral	Low	Human cytomegalovirus	EGFP expression	AVPdb_AVP1019avpdb / unavailable
CTPDB_P072553_ACT_camp_0002	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ9108camp / linked
CTPDB_P072553_ACT_camp_0003	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ9108camp / linked
CTPDB_P072553_ACT_dbaasp_0004	Antimicrobial	-	4 µg/ml	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0005	Antimicrobial	-	8 µg/ml	Escherichia coli	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0006	Antimicrobial	-	4 µg/ml	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0007	Antimicrobial	-	8 µg/ml	Pseudomonas aeruginosa 885149	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0008	Antimicrobial	-	8 µg/ml	Pseudomonas aeruginosa 891	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0009	Antimicrobial	-	4 µg/ml	Pseudomonas aeruginosa VA463/98	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0010	Antimicrobial	-	4-16 µg/ml	Klebsiella pneumoniae	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0011	Antimicrobial	-	64 µg/ml	Klebsiella oxytoca W99FI00049	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0012	Antimicrobial	-	>128 µg/ml	Proteus mirabilis W99FI0089	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0013	Antimicrobial	-	64 µg/ml	Proteus mirabilis W03VA1144	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0014	Antimicrobial	-	8 µg/ml	Klebsiella aerogenes W03BG0067	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0015	Antimicrobial	-	4 µg/ml	Enterobacter cloacae W03AN0041	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0016	Antimicrobial	-	>128 µg/ml	Morganella morganii W03VA1342	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0017	Antimicrobial	-	16 µg/ml	Acinetobacter baumannii AB1MG	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0018	Antimicrobial	-	32 µg/ml	Acinetobacter baumannii AB7MG	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0019	Antimicrobial	-	16 µg/ml	Citrobacter freundii W99FI00007	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0020	Antimicrobial	-	>128 µg/ml	Elizabethkingia meningoseptica CCUG 4310	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0021	Antimicrobial	-	64 µg/ml	Burkholderia cepacia SMC 71	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0022	Antimicrobial	-	>128 µg/ml	Serratia marcescens W99FI0111	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0023	Antimicrobial	-	>128 µg/ml	Stenotrophomonas maltophilia PT4/99	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0024	Antimicrobial	-	>128 µg/ml	Providencia stuartii W03FI0001	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0025	Antimicrobial	-	>128 µg/ml	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0026	Antimicrobial	-	128 µg/ml	Staphylococcus aureus MIU-68A	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dbaasp_0027	Antimicrobial	-	>64 µg/ml	Staphylococcus aureus ATCC 29213	Not reported by source	DBAASPS_1183_chain0dbaasp / linked
CTPDB_P072553_ACT_dramp_0028	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP09874dramp / linked
CTPDB_P072553_ACT_dramp_0029	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP18183dramp / linked
CTPDB_P072553_ACT_hemolytik_0030	Toxicity	Hemolytic	120.0 µg/ml	Erythrocytes	Not reported by source	1896hemolytik / linked
CTPDB_P072553_ACT_satpdb_0031	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	satpdb20156satpdb / linked
CTPDB_P072553_ACT_satpdb_0032	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb20156satpdb / linked
CTPDB_P072553_ACT_satpdb_0033	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb20156satpdb / linked

Provenance

Source database records (8)

apd

AP04474

Raw sequence

QKKIRVRLSA

avpdb

AVPdb_AVP1019

Raw sequence

QKKIRVRLSA

camp

CAMPSQ9108

Raw sequence

QKKIRVRLSA

dbaasp

DBAASPS_1183_chain0

Raw sequence

QKKIRVRLSA

dramp

DRAMP09874

Raw sequence

QKKIRVRLSA

dramp

DRAMP18183

Raw sequence

QKKIRVRLSA

hemolytik

1896

Raw sequence

QKKIRVRLSA

satpdb

satpdb20156

Raw sequence

QKKIRVRLSA

Citation trail

Literature (3 records)

Antimicrobial activity of novel dendrimeric peptides obtained by phage display selection and rational modification.

Pini A, Giuliani A, Falciani C, Runci Y, Ricci C, Lelli B, Malossi M, Neri P, Rossolini GM, Bracci L.2005

Antimicrob Agents Chemother2005PMID 15980334

Peptide-derivatized dendrimers inhibit human cytomegalovirus infection by blocking virus binding to cell surface heparan sulfate.

Luganini A, Giuliani A, Pirri G, Pizzuto L, Landolfo S, Gribaudo G.

Antiviral Res2010PMID 20083141

-

--PMID 17702663

IP evidence

Patents (1)

US 20110190198

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:12.728292+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "avpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCCCCSCCC"
}