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PEPDIA-INT-069735

Gold

Gaegurin 5 (1-11)[G3W][A4W][V8W][S10W]

85

Quality

7

Source DBs

88

Activities

37

Source refs

3

Literature

1

Patents

Integrated record

Sequence and molecular profile

FLWWLFKWAWK
Indexed sequence11 aa
1FLWWLFKWAWK

Length

11

Molecular weight

1610.97 Da

Formula

C89H111N17O12

Structure type

Linear

Synthesis

Synthetic

Chirality

L

Family

-

Gene

-

Residue composition

W
4
F
2
L
2
K
2
A
1

Physicochemical profile

Hydrophobic9

Membrane affinity proxy

Polar0

Solubility proxy

Charged2

Net charge proxy +2

Aromatic6

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1610.9402 Da

Molecular formula

C89H111N17O12

Theoretical pI

10.0027

Net charge at pH 7

1.7581

GRAVY

0.3273

Instability index

14.5091

Aromaticity

0.5455

Topological polar surface area

469.52 Ų

cLogP

5.9978

Hydrogen-bond donors

18

Hydrogen-bond acceptors

14

Rotatable bonds

45

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

FLWWLFKWAWK

HELM 2.0

validated simple linear

PEPTIDE1{F.L.W.W.L.F.K.W.A.W.K}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(N)Cc1ccccc1)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCCN)C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-069735,
  title = {Gaegurin 5 (1-11)[G3W][A4W][V8W][S10W]},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-069735},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Gaegurin 5 (1-11)[G3W][A4W][V8W][S10W]. (2026). PepDiana record PEPDIA-INT-069735. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-069735

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (88 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P069735_ACT_apd_0000AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceAP05677apd / linked
CTPDB_P069735_ACT_apd_0001ToxicityHemolyticNot available in the current structured importUnknownNot reported by sourceAP05677apd / linked
CTPDB_P069735_ACT_camp_0002AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceCAMPSQ13774camp / linked
CTPDB_P069735_ACT_camp_0003AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceCAMPSQ13774camp / linked
CTPDB_P069735_ACT_cancerppd_0032AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1728cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0033Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1728cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0034AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1729cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0035Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1729cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0036AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1730cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0037Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1730cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0038AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1731cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0039Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1731cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0040AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1732cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0041Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1732cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0042AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1733cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0043Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1733cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0044AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1737cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0045Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1737cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0046AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1741cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0047Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1741cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0048AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1765cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0049Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1765cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0050AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1766cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0051Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1766cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0052AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1767cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0053Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1767cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0054AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1768cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0055Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1768cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0056AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1769cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0057Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1769cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0058AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1770cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0059Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1770cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0060AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1771cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0061Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1771cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0062AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1772cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0063Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1772cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0004AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3233cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0005Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3233cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0006AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3234cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0007Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3234cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0008AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3235cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0009Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3235cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0010AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3236cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0011Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3236cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0012AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3237cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0013Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3237cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0014AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3238cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0015Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3238cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0016AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3239cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0017Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3239cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0018AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3734cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0019Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3734cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0020AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3735cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0021Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3735cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0022AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3736cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0023Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3736cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0024AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3737cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0025Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3737cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0026AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3738cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0027Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3738cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0028AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3739cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0029Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3739cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0030AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3740cancerppd / linked
CTPDB_P069735_ACT_cancerppd_0031Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3740cancerppd / linked
CTPDB_P069735_ACT_dbaasp_0064Antimicrobial-3.1 µg/mlBacillus subtilis ATCC 6633Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0065Antimicrobial-3.1 µg/mlMicrococcus luteus ATCC 10240Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0066Antimicrobial-6.3 µg/mlStaphylococcus aureus ATCC 6538PNot reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0067Antimicrobial-3.1 µg/mlStaphylococcus epidermidis ATCC 12228Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0068Antimicrobial->200 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0069Antimicrobial-200 µg/mlShigella dysenteriae ATCC 9752Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0070Antimicrobial->200 µg/mlSalmonella enterica subsp. enterica serovar Typhimurium ATCC 14028Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0071Antimicrobial-200 µg/mlKlebsiella pneumoniae ATCC 10031Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0072Antimicrobial->200 µg/mlPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0073Antimicrobial-22.59 µMHuman renal carcinoma A498Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0074Antimicrobial-15.88 µMHuman lung carcinoma A549Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0075Antimicrobial-14.80 µMHuman colon adenocarcinoma HCT 116Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0076Antimicrobial-13.77 µMHuman gastric cancer MKN 45Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0077Antimicrobial-24.32 µMHuman prostate adenocarcinoma PC-3Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0078Antimicrobial-13.16 µMHuman skin melanoma SK-MEL-2Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dbaasp_0079Antimicrobial-14.58 µMHuman ovarian adenocarcinoma SK-OV-3Not reported by sourceDBAASPS_941_chain0dbaasp / linked
CTPDB_P069735_ACT_dramp_0080Antimicrobial-Not available in the current structured importUnknownNot reported by sourceDRAMP09411dramp / linked
CTPDB_P069735_ACT_dramp_0081Anticancer-Not available in the current structured importUnknownNot reported by sourceDRAMP09411dramp / linked
CTPDB_P069735_ACT_hemolytik_0082ToxicityHemolytic25.0 µg/mlErythrocytesNot reported by source1555hemolytik / linked
CTPDB_P069735_ACT_satpdb_0083Anticancer-Not available in the current structured importUnknownNot reported by sourcesatpdb13336satpdb / linked
CTPDB_P069735_ACT_satpdb_0084Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb13336satpdb / linked
CTPDB_P069735_ACT_satpdb_0085Anticancer-Not available in the current structured importUnknownNot reported by sourcesatpdb21466satpdb / linked
CTPDB_P069735_ACT_satpdb_0086ToxicityGeneral ToxicNot available in the current structured importUnknownNot reported by sourcesatpdb21466satpdb / linked
CTPDB_P069735_ACT_satpdb_0087Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb21466satpdb / linked

Provenance

Source database records (37)

apd

AP05677

Raw sequence

FLWWLFKWAWK

camp

CAMPSQ13774

Raw sequence

FLWWLFKWAWK

cancerppd

3233

Raw sequence

FLWWLFKWAWK

cancerppd

3234

Raw sequence

FLWWLFKWAWK

cancerppd

3235

Raw sequence

FLWWLFKWAWK

cancerppd

3236

Raw sequence

FLWWLFKWAWK

cancerppd

3237

Raw sequence

FLWWLFKWAWK

cancerppd

3238

Raw sequence

FLWWLFKWAWK

cancerppd

3239

Raw sequence

FLWWLFKWAWK

cancerppd

3734

Raw sequence

FLWWLFKWAWK

cancerppd

3735

Raw sequence

FLWWLFKWAWK

cancerppd

3736

Raw sequence

FLWWLFKWAWK

cancerppd

3737

Raw sequence

FLWWLFKWAWK

cancerppd

3738

Raw sequence

FLWWLFKWAWK

cancerppd

3739

Raw sequence

FLWWLFKWAWK

cancerppd

3740

Raw sequence

FLWWLFKWAWK

cancerppd

1728

Raw sequence

FLWWLFKWAWK

cancerppd

1729

Raw sequence

FLWWLFKWAWK

cancerppd

1730

Raw sequence

FLWWLFKWAWK

cancerppd

1731

Raw sequence

FLWWLFKWAWK

cancerppd

1732

Raw sequence

FLWWLFKWAWK

cancerppd

1733

Raw sequence

FLWWLFKWAWK

cancerppd

1737

Raw sequence

FLWWLFKWAWK

cancerppd

1741

Raw sequence

FLWWLFKWAWK

cancerppd

1765

Raw sequence

FLWWLFKWAWK

cancerppd

1766

Raw sequence

FLWWLFKWAWK

cancerppd

1767

Raw sequence

FLWWLFKWAWK

cancerppd

1768

Raw sequence

FLWWLFKWAWK

cancerppd

1769

Raw sequence

FLWWLFKWAWK

cancerppd

1770

Raw sequence

FLWWLFKWAWK

cancerppd

1771

Raw sequence

FLWWLFKWAWK

cancerppd

1772

Raw sequence

FLWWLFKWAWK

dbaasp

DBAASPS_941_chain0

Raw sequence

FLWWLFKWAWK

dramp

DRAMP09411

Raw sequence

FLWWLFKWAWK

hemolytik

1555

Raw sequence

FLWWLFKWAWK

satpdb

satpdb13336

Raw sequence

FLWWLFKWAWK

satpdb

satpdb21466

Raw sequence

FLWWLFKWAWK

Citation trail

Literature (3 records)

Activity optimization of an undecapeptide analogue derived from a frog-skin antimicrobial peptide.

Won HS, Kang SJ, Choi WS, Lee BJ. 2011

Mol Cells2011PMID 21110126

{"pubmed_id": "[None](http://www.ncbi.nlm.nih.gov/pubmed/None)", "year": "2011"}

-

--

IP evidence

Patents (1)

US 8076284

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:12.385336+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET
{
  "toxicity": [
    {
      "unit": "µg/ml",
      "value": "25",
      "source_db": "dbaasp",
      "assay_method": "5% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}
Source metadata
[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cancerppd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]
Structure metadata
{
  "source_db": "satpdb",
  "dssp_states": "CTTTTSCSSCC"
}