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PEPDIA-INT-068385

Gold

Gaegurin 5 (1-11)[A4W][V8W][S10K]

85

Quality

7

Source DBs

83

Activities

35

Source refs

3

Literature

1

Patents

Integrated record

Sequence and molecular profile

FLGWLFKWAKK
Indexed sequence11 aa
1FLGWLFKWAKK

Length

11

Molecular weight

1423.77 Da

Formula

C75H106N16O12

Structure type

Linear

Synthesis

Synthetic

Chirality

L

Family

-

Gene

-

Residue composition

K
3
F
2
L
2
W
2
G
1
A
1

Physicochemical profile

Hydrophobic7

Membrane affinity proxy

Polar0

Solubility proxy

Charged3

Net charge proxy +3

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1423.744 Da

Molecular formula

C75H106N16O12

Theoretical pI

10.3021

Net charge at pH 7

2.7571

GRAVY

0.1

Instability index

4.2

Aromaticity

0.3636

Topological polar surface area

463.96 Ų

cLogP

2.3102

Hydrogen-bond donors

17

Hydrogen-bond acceptors

15

Rotatable bonds

45

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

FLGWLFKWAKK

HELM 2.0

validated simple linear

PEPTIDE1{F.L.G.W.L.F.K.W.A.K.K}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(N)Cc1ccccc1)C(=O)NCC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-068385,
  title = {Gaegurin 5 (1-11)[A4W][V8W][S10K]},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-068385},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Gaegurin 5 (1-11)[A4W][V8W][S10K]. (2026). PepDiana record PEPDIA-INT-068385. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-068385

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (83 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P068385_ACT_apd_0000AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceAP05676apd / linked
CTPDB_P068385_ACT_camp_0001AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceCAMPSQ13773camp / linked
CTPDB_P068385_ACT_camp_0002AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceCAMPSQ13773camp / linked
CTPDB_P068385_ACT_cancerppd_0029AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1710cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0030Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1710cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0031AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1711cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0032Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1711cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0033AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1712cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0034Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1712cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0035AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1713cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0036Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1713cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0037AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1714cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0038Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1714cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0039AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1715cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0040Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1715cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0041AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1734cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0042Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1734cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0043AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1738cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0044Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1738cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0045AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1742cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0046Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1742cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0047AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1743cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0048Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1743cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0049AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1744cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0050Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1744cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0051AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1745cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0052Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1745cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0053AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1746cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0054Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1746cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0055AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1747cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0056Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1747cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0057AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay1748cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0058Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay1748cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0003AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3240cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0004Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3240cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0005AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3241cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0006Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3241cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0007AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3242cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0008Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3242cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0009AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3243cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0010Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3243cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0011AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3244cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0012Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3244cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0013AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3245cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0014Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3245cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0015AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3246cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0016Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3246cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0017AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3741cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0018Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3741cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0019AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3742cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0020Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3742cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0021AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3743cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0022Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3743cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0023AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3744cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0024Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3744cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0025AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3745cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0026Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3745cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0027AnticancerAnticancerNot available in the current structured importUnknownMTT/MTS assay3746cancerppd / linked
CTPDB_P068385_ACT_cancerppd_0028Antimicrobial-Not available in the current structured importUnknownMTT/MTS assay3746cancerppd / linked
CTPDB_P068385_ACT_dbaasp_0059Antimicrobial-6.3 µg/mlBacillus subtilis ATCC 6633Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0060Antimicrobial-3.1 µg/mlMicrococcus luteus ATCC 10240Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0061Antimicrobial-12.5 µg/mlStaphylococcus aureus ATCC 6538PNot reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0062Antimicrobial-6.3 µg/mlStaphylococcus epidermidis ATCC 12228Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0063Antimicrobial-12.5 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0064Antimicrobial-25 µg/mlShigella dysenteriae ATCC 9752Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0065Antimicrobial-50 µg/mlSalmonella enterica subsp. enterica serovar Typhimurium ATCC 14028Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0066Antimicrobial-12.5 µg/mlKlebsiella pneumoniae ATCC 10031Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0067Antimicrobial-25 µg/mlPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0068Antimicrobial-41.21 µMHuman renal carcinoma A498Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0069Antimicrobial-25.20 µMHuman lung carcinoma A549Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0070Antimicrobial-27.00 µMHuman colon adenocarcinoma HCT 116Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0071Antimicrobial-26.70 µMHuman gastric cancer MKN 45Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0072Antimicrobial-47.69 µMHuman prostate adenocarcinoma PC-3Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0073Antimicrobial-27.39 µMHuman skin melanoma SK-MEL-2Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dbaasp_0074Antimicrobial-24.76 µMHuman ovarian adenocarcinoma SK-OV-3Not reported by sourceDBAASPS_942_chain0dbaasp / linked
CTPDB_P068385_ACT_dramp_0075Antimicrobial-Not available in the current structured importUnknownNot reported by sourceDRAMP09408dramp / linked
CTPDB_P068385_ACT_dramp_0076Anticancer-Not available in the current structured importUnknownNot reported by sourceDRAMP09408dramp / linked
CTPDB_P068385_ACT_hemolytik_0077ToxicityHemolytic50.0 µg/mlErythrocytesNot reported by source1556hemolytik / linked
CTPDB_P068385_ACT_satpdb_0078Anticancer-Not available in the current structured importUnknownNot reported by sourcesatpdb17893satpdb / linked
CTPDB_P068385_ACT_satpdb_0079ToxicityGeneral ToxicNot available in the current structured importUnknownNot reported by sourcesatpdb17893satpdb / linked
CTPDB_P068385_ACT_satpdb_0080Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb17893satpdb / linked
CTPDB_P068385_ACT_satpdb_0081Anticancer-Not available in the current structured importUnknownNot reported by sourcesatpdb26327satpdb / linked
CTPDB_P068385_ACT_satpdb_0082Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb26327satpdb / linked

Provenance

Source database records (35)

apd

AP05676

Raw sequence

FLGWLFKWAKK

camp

CAMPSQ13773

Raw sequence

FLGWLFKWAKK

cancerppd

3240

Raw sequence

FLGWLFKWAKK

cancerppd

3241

Raw sequence

FLGWLFKWAKK

cancerppd

3242

Raw sequence

FLGWLFKWAKK

cancerppd

3243

Raw sequence

FLGWLFKWAKK

cancerppd

3244

Raw sequence

FLGWLFKWAKK

cancerppd

3245

Raw sequence

FLGWLFKWAKK

cancerppd

3246

Raw sequence

FLGWLFKWAKK

cancerppd

3741

Raw sequence

FLGWLFKWAKK

cancerppd

3742

Raw sequence

FLGWLFKWAKK

cancerppd

3743

Raw sequence

FLGWLFKWAKK

cancerppd

3744

Raw sequence

FLGWLFKWAKK

cancerppd

3745

Raw sequence

FLGWLFKWAKK

cancerppd

3746

Raw sequence

FLGWLFKWAKK

cancerppd

1710

Raw sequence

FLGWLFKWAKK

cancerppd

1711

Raw sequence

FLGWLFKWAKK

cancerppd

1712

Raw sequence

FLGWLFKWAKK

cancerppd

1713

Raw sequence

FLGWLFKWAKK

cancerppd

1714

Raw sequence

FLGWLFKWAKK

cancerppd

1715

Raw sequence

FLGWLFKWAKK

cancerppd

1734

Raw sequence

FLGWLFKWAKK

cancerppd

1738

Raw sequence

FLGWLFKWAKK

cancerppd

1742

Raw sequence

FLGWLFKWAKK

cancerppd

1743

Raw sequence

FLGWLFKWAKK

cancerppd

1744

Raw sequence

FLGWLFKWAKK

cancerppd

1745

Raw sequence

FLGWLFKWAKK

cancerppd

1746

Raw sequence

FLGWLFKWAKK

cancerppd

1747

Raw sequence

FLGWLFKWAKK

cancerppd

1748

Raw sequence

FLGWLFKWAKK

dbaasp

DBAASPS_942_chain0

Raw sequence

FLGWLFKWAKK

dramp

DRAMP09408

Raw sequence

FLGWLFKWAKK

hemolytik

1556

Raw sequence

FLGWLFKWAKK

satpdb

satpdb17893

Raw sequence

FLGWLFKWAKK

satpdb

satpdb26327

Raw sequence

FLGWLFKWAKK

Citation trail

Literature (3 records)

Activity optimization of an undecapeptide analogue derived from a frog-skin antimicrobial peptide.

Won HS, Kang SJ, Choi WS, Lee BJ. 2011

Mol Cells2011PMID 21110126

{"pubmed_id": "[None](http://www.ncbi.nlm.nih.gov/pubmed/None)", "year": "2011"}

-

--

IP evidence

Patents (1)

US 8076284

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:12.385336+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET
{
  "toxicity": [
    {
      "unit": "µg/ml",
      "value": "50",
      "source_db": "dbaasp",
      "assay_method": "5% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}
Source metadata
[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cancerppd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]
Structure metadata
{
  "source_db": "satpdb",
  "dssp_states": "CCCTTTSSCCC"
}