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PEPDIA-INT-066588

Gold

Teriparatide

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF

Indexed sequence34 aa

1SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF

Length

Molecular weight

4117.79 Da

Formula

C181H291N55O51S2

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic13

Membrane affinity proxy

Polar8

Solubility proxy

Charged12

Net charge proxy +4

Aromatic5

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

4117.7146 Da

Molecular formula

C181H291N55O51S2

Theoretical pI

8.2868

Net charge at pH 7

0.7282

GRAVY

-0.6706

Instability index

62.5235

Aromaticity

0.0588

Topological polar surface area

1752.65 Å²

cLogP

-15.2403

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

144

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF

HELM 2.0

validated simple linear

PEPTIDE1{S.V.S.E.I.Q.L.M.H.N.L.G.K.H.L.N.S.M.E.R.V.E.W.L.R.K.K.L.Q.D.V.H.N.F}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(NC(=O)C(N)CO)C(C)C)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)NC(CCC(=O)O)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(N)=O)C(=O)NC(CC(=O)O)C(=O)NC(C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CC(N)=O)C(=O)NC(Cc1ccccc1)C(=O)O)C(C)C)C(C)C

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-066588,
  title = {Teriparatide},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-066588},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Teriparatide. (2026). PepDiana record PEPDIA-INT-066588. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-066588

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (8 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P066588_ACT_peptherdia_0000	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	20peptherdia / linked
CTPDB_P066588_ACT_thpdb_0001	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1120_10584_rec0thpdb / unavailable
CTPDB_P066588_ACT_thpdb_0002	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1120_10585_rec1thpdb / unavailable
CTPDB_P066588_ACT_thpdb_0003	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1120_10586_rec2thpdb / unavailable
CTPDB_P066588_ACT_thpdb_0004	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1120_10587_rec3thpdb / unavailable
CTPDB_P066588_ACT_topicalpdb_0005	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	<1% PTH dissolved in normal saline recovered in the lower chamber of the Franz cell after 24 h; Franz cell; in vitro	1215topicalpdb / linked
CTPDB_P066588_ACT_topicalpdb_0006	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	<1% PTH dissolved in propylene glycol recovered in the lower chamber of the Franz cell after 24 h; Franz cell; in vitro	1216topicalpdb / linked
CTPDB_P066588_ACT_topicalpdb_0007	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	45% PTH formulated in Novasome A cream recovered in the lower chamber of the Franz cell after 24 h; Franz cell; in vitro	1217topicalpdb / linked

Provenance

Source database records (8)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

peptherdia

Raw sequence

SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF

thpdb

Th1120_10584_rec0

Raw sequence

SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF

thpdb

Th1120_10585_rec1

Raw sequence

SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF

thpdb

Th1120_10586_rec2

Raw sequence

SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF

thpdb

Th1120_10587_rec3

Raw sequence

SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF

topicalpdb

1215

Raw sequence

SVSEIQLMHNLGKHL NSMERVEWLRKKLQD VHNF

topicalpdb

1216

Raw sequence

SVSEIQLMHNLGKHL NSMERVEWLRKKLQD VHNF

topicalpdb

1217

Raw sequence

SVSEIQLMHNLGKHL NSMERVEWLRKKLQD VHNF

Citation trail

Literature (2 records)

[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB06285", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB06285)"}, {"text": "fda.gov", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021318s015lbl.pdf", "markdown": "[fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021318s015lbl.pdf)"}, {"text": "europa.eu", "url": "https://www.ema.europa.eu/en/documents/scientific-discussion/forsteo-epar-scientific-discussion_en.pdf", "markdown":

[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB06285", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB06285)"}, {"text": "fda.gov", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021318s015lbl.pdf", "markdown": "[fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021318s015lbl.pdf)"}, {"text": "europa.eu", "url": "https://www.ema.europa.eu/en/documents/scientific-discussion/forsteo-epar-scientific-discussion_en.pdf", "markdown":

-

--PMID 12932245

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:21.345173+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "source_db": "thpdb",
      "assay_method": "Effects of overexposure may include headaches, dizziness, dizziness, decreased blood pressured, decreased fetal survival, leg cramps, changes in clinical chemistry including increased in blood levels ",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Effects of overexposure may include headaches, dizziness, dizziness, decreased blood pressured, decreased fetal survival, leg cramps, changes in clinical chemistry including increased in blood levels ",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Effects of overexposure may include headaches, dizziness, dizziness, decreased blood pressured, decreased fetal survival, leg cramps, changes in clinical chemistry including increased in blood levels ",
      "toxicity_type": "Toxicity"
    },
    {
      "source_db": "thpdb",
      "assay_method": "Effects of overexposure may include headaches, dizziness, dizziness, decreased blood pressured, decreased fetal survival, leg cramps, changes in clinical chemistry including increased in blood levels ",
      "toxicity_type": "Toxicity"
    }
  ]
}

Source metadata

[
  {
    "source_db": "peptherdia",
    "organism_name": "Unknown"
  },
  {
    "source_db": "thpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "topicalpdb",
    "organism_name": "Unknown"
  }
]

Clinical trials

[
  {
    "status": "Therapeutic",
    "drug_name": "Teriparatide",
    "source_db": "peptherdia",
    "indication": "Treatment of osteoporosis",
    "approval_year": 2002,
    "approval_agency": "FDA",
    "administration_route": "SC"
  }
]

Approved drug annotations

{
  "status": "Therapeutic",
  "drug_name": "Teriparatide",
  "source_db": "peptherdia",
  "indication": "Treatment of osteoporosis",
  "approval_year": 2002,
  "approval_agency": "FDA",
  "administration_route": "SC"
}