ProForma 2.0
validated simple linear
STYQT
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PEPDIA-INT-063632
GoldPepDiana tier derived from the internal quality score plus activity and literature coverage; it is not an external database rating.ACE inhibitory peptide
85
Quality PepDiana 0–100 composite of sequence, source, activity, literature, and cross-database evidence completeness.
3
Source DBs
5
Activities
4
Source refs
3
Literature
0
Patents
Integrated record
Sequence and molecular profile
STYQT
Indexed sequence5 aa
1STYQT
Length
5
Molecular weight
598.61 Da
Formula
C25H38N6O11
Structure type
Linear
Synthesis
-
Chirality
-
Family
-
Gene
-
Residue composition
T
2
S
1
Y
1
Q
1
Physicochemical profile
Hydrophobic1
Membrane affinity proxy
Polar4
Solubility proxy
Charged0
Net charge proxy +0
Aromatic1
Binding interaction proxy
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.
Computed properties
physchem-20260620Molecular weight
598.6028 Da
Molecular formula
C25H38N6O11
Theoretical pI
5.2398
Net charge at pH 7
-0.5409
GRAVY
-1.4
Instability index
8
Aromaticity
0.2
Topological polar surface area
303.73 Ų
cLogP
-4.6948
Hydrogen-bond donors
11
Hydrogen-bond acceptors
11
Rotatable bonds
17
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{S.T.Y.Q.T}$$$$V2.0
Canonical SMILES
validated
CC(O)C(NC(=O)C(CCC(N)=O)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(N)CO)C(C)O)C(=O)O
Isomeric SMILES
validated
C[C@@H](O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)O
Follow-up research
External analysis tools
Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.
Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.
Research workflow
Citation and local history
BibTeX
@misc{PEPDIA-INT-063632,
title = {ACE inhibitory peptide},
author = {{PepDiana Consortium}},
year = {2026},
howpublished = {PepDiana Multifunctional Peptide Database},
url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-063632},
note = {Accessed from local PepDiana development build}
}APA-style note
ACE inhibitory peptide. (2026). PepDiana record PEPDIA-INT-063632. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-063632
This record is saved to local recent-view history so it can reappear on the peptide browser page.
Integrated source-database annotations
Biological activity (5 records)
| Stable record | Activity | Subtype | Value | Target | Assay method | Source |
|---|---|---|---|---|---|---|
| CTPDB_P063632_ACT_ahtpdb_0000 | Metabolic/Cardiovascular | ACE Inhibitor | 300.4 µM | Unknown | Cushman and Cheung (1971) | 1234ahtpdb / linked |
| CTPDB_P063632_ACT_ahtpdb_0001 | Metabolic/Cardiovascular | ACE Inhibitor | Not available for this observation | Unknown | Not reported by source | 1947ahtpdb / linked |
| CTPDB_P063632_ACT_plantpepdb_0002 | Metabolic/Cardiovascular | ACE Inhibitor | Not available for this observation | Unknown | Not reported by source | PPepDB_3738plantpepdb / linked |
| CTPDB_P063632_ACT_plantpepdb_0003 | Metabolic/Cardiovascular | Antihypertensive | Not available for this observation | Unknown | Not reported by source | PPepDB_3738plantpepdb / linked |
| CTPDB_P063632_ACT_satpdb_0004 | Metabolic/Cardiovascular | Antihypertensive | Not available for this observation | Unknown | Not reported by source | satpdb11598satpdb / linked |
Provenance
Source database records (4)
Citation trail
Literature (3 records)
Antihypertensive Properties of Plant Protein Derived Peptides
Anne Pihlanto and Sari Ma?kinen
Bioactive Food Peptides in Health and Disease Edited by Blanca Hernandez-Ledesma and Chia-Chien Hsieh, ISBN 978-953-51-0964-8, 276 pages2013
Pharmaceutical applications of bioactive peptides
MK Danquah1,2,*, D Agyei1
OA Biotechnology 2012 Dec 29;1(2):5.2012
-
-
Audit surface
Raw annotations and release metadata
Integrated record last updated: 2026-04-15T00:59:11.196781+00:00
Modification summary
No structured modification annotations are available for this record.
Source metadata
[
{
"source_db": "ahtpdb",
"organism_name": "Unknown"
},
{
"source_db": "plantpepdb",
"organism_name": "Unknown"
},
{
"source_db": "satpdb",
"organism_name": "Unknown"
}
]Structure metadata
{
"source_db": "satpdb",
"dssp_states": "CGGGC"
}