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PEPDIA-INT-062072

Silver

Cyclo(Pro-Trp), Diketopiperazine (PW)

65

Quality

2

Source DBs

28

Activities

3

Source refs

3

Literature

0

Patents

Integrated record

Sequence and molecular profile

PW
Indexed sequence2 aa
1PW

Length

2

Molecular weight

301.35 Da

Formula

C16H19N3O3

Structure type

-

Synthesis

Synthetic

Chirality

-

Family

-

Gene

-

Residue composition

P
1
W
1

Physicochemical profile

Hydrophobic1

Membrane affinity proxy

Polar0

Solubility proxy

Charged0

Net charge proxy +0

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

301.3404 Da

Molecular formula

C16H19N3O3

Theoretical pI

5.955

Net charge at pH 7

-0.0415

GRAVY

-1.25

Instability index

-9.4

Aromaticity

0.5

Topological polar surface area

94.22 Ų

cLogP

1.0318

Hydrogen-bond donors

4

Hydrogen-bond acceptors

3

Rotatable bonds

5

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

PW

HELM 2.0

validated simple linear

PEPTIDE1{P.W}$$$$V2.0

Canonical SMILES

validated

O=C(O)C(Cc1c[nH]c2ccccc12)NC(=O)C1CCCN1

Isomeric SMILES

validated

O=C(O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-062072,
  title = {Cyclo(Pro-Trp), Diketopiperazine (PW)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-062072},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Cyclo(Pro-Trp), Diketopiperazine (PW). (2026). PepDiana record PEPDIA-INT-062072. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-062072

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (28 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P062072_ACT_dbaasp_0000Antimicrobial-1 µg/mlBacillus subtilisNot reported by sourceDBAASPS_6160_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0001Antimicrobial-1 µg/mlMicrococcus luteusNot reported by sourceDBAASPS_6160_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0002Antimicrobial-1 µg/mlStaphylococcus aureusNot reported by sourceDBAASPS_6160_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0003Antimicrobial-100 µg/mlEscherichia coliNot reported by sourceDBAASPS_6160_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0004Antimicrobial-85 µg/mlPseudomonas aeruginosaNot reported by sourceDBAASPS_6160_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0005Antimicrobial-100 µg/mlKlebsiella aerogenesNot reported by sourceDBAASPS_6160_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0006Antimicrobial-80 µg/mlKlebsiella pneumoniaeNot reported by sourceDBAASPS_6160_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0007Antimicrobial-50 µg/mlCandida albicansNot reported by sourceDBAASPS_6160_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0008Antimicrobial-45 µg/mlSaccharomyces cerevisiaeNot reported by sourceDBAASPS_6160_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0009Antimicrobial-NAHuman hepatocellular carcinoma HepG2Not reported by sourceDBAASPS_6160_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0010Antimicrobial-8 µg/mlStaphylococcus epidermidis MTCC 10623Not reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0011Antimicrobial-16 µg/mlStaphylococcus epidermidis MTCC 10623Not reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0012Antimicrobial-4 µg/mlStaphylococcus aureus MTCC 902Not reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0013Antimicrobial-8 µg/mlStaphylococcus aureus MTCC 902Not reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0014Antimicrobial-32 µg/mlEscherichia coli MTCC 2622Not reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0015Antimicrobial-32 µg/mlEscherichia coli MTCC 2622Not reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0016Antimicrobial-16 µg/mlPseudomonas aeruginosa MTCC 2642Not reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0017Antimicrobial-16 µg/mlPseudomonas aeruginosa MTCC 2642Not reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0018Antimicrobial-64 µg/mlKlebsiella pneumoniae MTCC 109Not reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0019Antimicrobial-64 µg/mlKlebsiella pneumoniae MTCC 109Not reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0020Antimicrobial-16 µg/mlStaphylococcus aureusNot reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0021Antimicrobial-32 µg/mlStaphylococcus aureusNot reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0022Antimicrobial-32 µg/mlAspergillus flavus MTCC 183Not reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0023Antimicrobial-8 µg/mlCandida albicans MTCC 277Not reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0024Antimicrobial-4 µg/mlCandida tropicalis MTCC 184Not reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0025Antimicrobial-1 µg/mlTrichophyton rubrum MTCC 296Not reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_dbaasp_0026Antimicrobial-2 µg/mlCryptococcus neoformansNot reported by sourceDBAASPS_6793_chain0dbaasp / linked
CTPDB_P062072_ACT_plantpepdb_0027Antioxidant-Not available in the current structured importUnknownNot reported by sourcePPepDB_429plantpepdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

1

Records

1

Papers

1

Positive

0

Negative

1

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003936View all experimental records

Provenance

Source database records (3)

dbaasp

DBAASPS_6160_chain0

Raw sequence

PW

dbaasp

DBAASPS_6793_chain0

Raw sequence

PW

plantpepdb

PPepDB_429

Raw sequence

PW

Citation trail

Literature (3 records)

Antimicrobial activity, biocompatibility and hydrogelation ability of dipeptide-based amphiphiles.

Mitra RN, Shome A, Paul P, Das PK

Org Biomol Chem2009PMID 19081951

Cyclic dipeptides from rhabditid entomopathogenic nematode-associated Bacillus cereus have antimicrobial activities.

Nishanth Kumar S, Nath VS, Pratap Chandran R, Nambisan B

World J Microbiol Biotechnol2014PMID 23979826

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:17.814455+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET
{
  "toxicity": [
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human fibroblasts"
    }
  ]
}
Source metadata
[
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  }
]