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PEPDIA-INT-061847

Gold

Dermaseptin S4 (1-10)AMD[M4K]

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

ALWKTLLKKV

Indexed sequence10 aa

1ALWKTLLKKV

Length

Molecular weight

1199.55 Da

Formula

C59H102N14O12

Structure type

Linear

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic6

Membrane affinity proxy

Polar1

Solubility proxy

Charged3

Net charge proxy +3

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1199.5277 Da

Molecular formula

C59H102N14O12

Theoretical pI

10.3023

Net charge at pH 7

2.7929

GRAVY

0.41

Instability index

15.7

Aromaticity

0.1

Topological polar surface area

439.3 Å²

cLogP

0.0675

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

ALWKTLLKKV

HELM 2.0

validated simple linear

PEPTIDE1{A.L.W.K.T.L.L.K.K.V}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(C)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(C(=O)O)C(C)C)C(C)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)O)C(C)C)[C@@H](C)O

Follow-up research

External analysis tools

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-061847,
  title = {Dermaseptin S4 (1-10)AMD[M4K]},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-061847},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Dermaseptin S4 (1-10)AMD[M4K]. (2026). PepDiana record PEPDIA-INT-061847. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-061847

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (12 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P061847_ACT_camp_0000	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ17552camp / linked
CTPDB_P061847_ACT_camp_0001	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ17552camp / linked
CTPDB_P061847_ACT_camp_0002	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ17552camp / linked
CTPDB_P061847_ACT_dbaasp_0003	Antimicrobial	-	40±1 µM	Escherichia coli TG1	Not reported by source	DBAASPS_620_chain0dbaasp / linked
CTPDB_P061847_ACT_dbaasp_0004	Antimicrobial	-	>50 µM	Leishmania major (promastigote)	Not reported by source	DBAASPS_620_chain0dbaasp / linked
CTPDB_P061847_ACT_dbaasp_0005	Antimicrobial	-	30±5 µM	Cryptococcus neoformans B3501	Not reported by source	DBAASPS_620_chain0dbaasp / linked
CTPDB_P061847_ACT_dbaasp_0006	Antimicrobial	-	>50 µM	Staphylococcus aureus B38302	Not reported by source	DBAASPS_620_chain0dbaasp / linked
CTPDB_P061847_ACT_dbaasp_0007	Antimicrobial	-	50±10 µM	Escherichia coli U16318	Not reported by source	DBAASPS_620_chain0dbaasp / linked
CTPDB_P061847_ACT_dbaasp_0008	Antimicrobial	-	>32 µM	Escherichia coli O157:H7 ATCC 43895	Not reported by source	DBAASPS_620_chain0dbaasp / linked
CTPDB_P061847_ACT_hemolytik_0009	Toxicity	Hemolytic	100.0 µM	Erythrocytes	Not reported by source	1019hemolytik / linked
CTPDB_P061847_ACT_satpdb_0010	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb18766satpdb / linked
CTPDB_P061847_ACT_satpdb_0011	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb18766satpdb / linked

Provenance

Source database records (4)

camp

CAMPSQ17552

Raw sequence

ALWKTLLKKV

dbaasp

DBAASPS_620_chain0

Raw sequence

ALWKTLLKKV

hemolytik

1019

Raw sequence

ALWKTLLKKV

satpdb

satpdb18766

Raw sequence

ALWKTLLKKV

Citation trail

Literature (4 records)

-

--PMID 11847217

-

--PMID 16436700

Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity

Feder R, Dagan A, Mor A

J Biol Chem2000PMID 10660589

Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity

Feder R, Dagan A, Mor A

J Biol Chem2000PMID 16436701

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:15.432864+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": ">100",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": ">50",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCTTTSGGGC"
}