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PEPDIA-INT-058212

Gold

Bradykinin (Pro-rich; PrAMPs, natural AMPs; neuropeptide, human; primates, mammals, animals)

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

RPPGFSPFR

Indexed sequence9 aa

1RPPGFSPFR

Length

Molecular weight

1060.23 Da

Formula

C50H73N15O11

Structure type

Linear

Synthesis

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic2

Membrane affinity proxy

Polar1

Solubility proxy

Charged2

Net charge proxy +2

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1060.2085 Da

Molecular formula

C50H73N15O11

Theoretical pI

Net charge at pH 7

1.7601

GRAVY

-1.0444

Instability index

121.9111

Aromaticity

0.2222

Topological polar surface area

413.78 Å²

cLogP

-3.5691

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

RPPGFSPFR

HELM 2.0

validated simple linear

PEPTIDE1{R.P.P.G.F.S.P.F.R}$$$$V2.0

Canonical SMILES

validated

N=C(N)NCCCC(N)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NCC(=O)NC(Cc1ccccc1)C(=O)NC(CO)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(=N)N)C(=O)O

Isomeric SMILES

validated

N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-058212,
  title = {Bradykinin (Pro-rich; PrAMPs, natural AMPs; neuropeptide, human; primates, mammals, animals)},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-058212},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Bradykinin (Pro-rich; PrAMPs, natural AMPs; neuropeptide, human; primates, mammals, animals). (2026). PepDiana record PEPDIA-INT-058212. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-058212

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (11 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P058212_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP01473apd / linked
CTPDB_P058212_ACT_apd_0001	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP01473apd / linked
CTPDB_P058212_ACT_dramp_0002	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP01262dramp / linked
CTPDB_P058212_ACT_dramp_0003	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP08723dramp / linked
CTPDB_P058212_ACT_dramp_0004	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP08723dramp / linked
CTPDB_P058212_ACT_satpdb_0005	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb26950satpdb / linked
CTPDB_P058212_ACT_satpdb_0006	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb26950satpdb / linked
CTPDB_P058212_ACT_satpdb_0007	Bioregulatory	Cell-Cell Communication	Not available in the current structured import	Unknown	Not reported by source	satpdb26950satpdb / linked
CTPDB_P058212_ACT_satpdb_0008	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb26950satpdb / linked
CTPDB_P058212_ACT_satpdb_0009	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb26950satpdb / linked
CTPDB_P058212_ACT_topicalpdb_0010	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	Instillation of bradykinin increased extravasation of Evans blue dye to 93.5±7.5 ng/ml from baseline 8.54±0.93 ng/ml; Evan's blue dye; in vivo	1394topicalpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003998 View all experimental records

Provenance

Source database records (8)

apd

AP01473

Raw sequence

RPPGFSPFR

conoserver

P01330

Raw sequence

RPPGFSPFR

conoserver

P01351

Raw sequence

RPPGFSPFR

conoserver

P01369

Raw sequence

RPPGFSPFR

dramp

DRAMP01262

Raw sequence

RPPGFSPFR

dramp

DRAMP08723

Raw sequence

RPPGFSPFR

satpdb

satpdb26950

Raw sequence

RPPGFSPFR

topicalpdb

1394

Raw sequence

RPPGFSPFR

Citation trail

Literature (5 records)

{"reference": "Life Sci. 2002 Jul 5;71(7):747-50", "title": "Direct antimicrobial properties of substance P.", "author": "Kowalska K, Carr DB, Lipkowski AW.2002"}

[{"full_text": "Craig,A.Grey., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J. and Cruz,L.J. (2002) Contulakin-G, analogs thereof and uses thereforPatent: US 6369193 09-APR-2002", "authors": "Craig,A.Grey., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J. and Cruz,L.J.", "year": "2002", "title": "Contulakin-G, analogs thereof and uses thereforPatent: US 6369193 09-APR-2002", "journal": "", "url": null, "pmid": null}]

[{"full_text": "Craig,A.Grey., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J. and Cruz,L.J. (2002) Contulakin-G, analogs thereof and uses thereforPatent: US 6369193 09-APR-2002", "authors": "Craig,A.Grey., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J. and Cruz,L.J.", "year": "2002", "title": "Contulakin-G, analogs thereof and uses thereforPatent: US 6369193 09-APR-2002", "journal": "", "url": null, "pmid": null}]

[{"full_text": "Craig,A.G., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J., Cruz,L.J., Wagstaff,J.D., Layer,R.T., Jones,R.M. and McCabe,R.T. (2002) Contulakin-G, analogs thereof and uses thereofPatent: US 6489298 03-DEC-2002", "authors": "Craig,A.G., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J., Cruz,L.J., Wagstaff,J.D., Layer,R.T., Jones,R.M. and McCabe,R.T.", "year": "2002", "title": "Contulakin-G, analogs thereof and uses thereofPatent: US 6489298 03-DEC-

[{"full_text": "Craig,A.G., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J., Cruz,L.J., Wagstaff,J.D., Layer,R.T., Jones,R.M. and McCabe,R.T. (2002) Contulakin-G, analogs thereof and uses thereofPatent: US 6489298 03-DEC-2002", "authors": "Craig,A.G., Griffen,D., Olivera,B.M., Watkins,M., Hillyard,D.R., Imperial,J., Cruz,L.J., Wagstaff,J.D., Layer,R.T., Jones,R.M. and McCabe,R.T.", "year": "2002", "title": "Contulakin-G, analogs thereof and uses thereofPatent: US 6489298 03-DEC-

Peptidomic dissection of the skin secretion of Phasmahyla jandaia (Bokermann and Sazima, 1978) (Anura, Hylidae, Phyllomedusinae).

Rates B, Silva LP, Ireno IC, Leite FS, Borges MH, Bloch C Jr, De Lima ME, Pimenta AM.

Toxicon2011PMID 20932854

-

--PMID 8719791

IP evidence

Patents (1)

US 20080286210

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.491115+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "conoserver",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "topicalpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCTTSTTTC"
}