ProForma 2.0
validated simple linear
GIVEQCCASVCSLYQLENYCN
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PEPDIA-INT-058191
GoldPepDiana tier derived from the internal quality score plus activity and literature coverage; it is not an external database rating.Insulin A chain
70
Quality PepDiana 0–100 composite of sequence, source, activity, literature, and cross-database evidence completeness.
3
Source DBs
9
Activities
3
Source refs
1
Literature
0
Patents
Integrated record
Sequence and molecular profile
GIVEQCCASVCSLYQLENYCN
Indexed sequence21 aa
1GIVEQCCASVCSLYQLENYCN
Length
21
Molecular weight
2339.68 Da
Formula
C97H151N25O34S4
Structure type
Linear
Synthesis
Ribosomal
Chirality
-
Family
-
Gene
-
Residue composition
C
4
V
2
E
2
Q
2
S
2
L
2
Y
2
N
2
G
1
I
1
A
1
Physicochemical profile
Hydrophobic8
Membrane affinity proxy
Polar10
Solubility proxy
Charged2
Net charge proxy -2
Aromatic2
Binding interaction proxy
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.
Computed properties
physchem-20260620Molecular weight
2339.6435 Da
Molecular formula
C97H151N25O34S4
Theoretical pI
4.05
Net charge at pH 7
-2.2759
GRAVY
0.319
Instability index
7.019
Aromaticity
0.0952
Topological polar surface area
973.2 Ų
cLogP
-11.1923
Hydrogen-bond donors
36
Hydrogen-bond acceptors
36
Rotatable bonds
75
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{G.I.V.E.Q.C.C.A.S.V.C.S.L.Y.Q.L.E.N.Y.C.N}$$$$V2.0
Canonical SMILES
validated
CCC(C)C(NC(=O)CN)C(=O)NC(C(=O)NC(CCC(=O)O)C(=O)NC(CCC(N)=O)C(=O)NC(CS)C(=O)NC(CS)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(C(=O)NC(CS)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CS)C(=O)NC(CC(N)=O)C(=O)O)C(C)C)C(C)C
Isomeric SMILES
validated
CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)C(C)C)C(C)C
Follow-up research
External analysis tools
Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.
Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.
Research workflow
Citation and local history
BibTeX
@misc{PEPDIA-INT-058191,
title = {Insulin A chain},
author = {{PepDiana Consortium}},
year = {2026},
howpublished = {PepDiana Multifunctional Peptide Database},
url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-058191},
note = {Accessed from local PepDiana development build}
}APA-style note
Insulin A chain. (2026). PepDiana record PEPDIA-INT-058191. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-058191
This record is saved to local recent-view history so it can reappear on the peptide browser page.
Integrated source-database annotations
Biological activity (9 records)
| Stable record | Activity | Subtype | Value | Target | Assay method | Source |
|---|---|---|---|---|---|---|
| CTPDB_P058191_ACT_dbaasp_0000 | Antimicrobial | - | NA | Candida albicans | Not reported by source | DBAASPS_4095_chain0dbaasp / linked |
| CTPDB_P058191_ACT_dbaasp_0001 | Antimicrobial | - | NA | Candida glabrata ATCC 90030 | Not reported by source | DBAASPS_4095_chain0dbaasp / linked |
| CTPDB_P058191_ACT_dbaasp_0002 | Antimicrobial | - | NA | Candida krusei | Not reported by source | DBAASPS_4095_chain0dbaasp / linked |
| CTPDB_P058191_ACT_dbaasp_0003 | Antimicrobial | - | NA | Cryptococcus neoformans | Not reported by source | DBAASPS_4095_chain0dbaasp / linked |
| CTPDB_P058191_ACT_dbaasp_0004 | Antimicrobial | - | NA | Saccharomyces cerevisiae | Not reported by source | DBAASPS_4095_chain0dbaasp / linked |
| CTPDB_P058191_ACT_dbaasp_0005 | Antimicrobial | - | NA | Candida albicans | Not reported by source | DBAASPS_4095_chain0dbaasp / linked |
| CTPDB_P058191_ACT_dbaasp_0006 | Antimicrobial | - | NA | Candida glabrata | Not reported by source | DBAASPS_4095_chain0dbaasp / linked |
| CTPDB_P058191_ACT_satpdb_0007 | Bioregulatory | Cell-Cell Communication | Not available in the current structured import | Unknown | Not reported by source | satpdb13429satpdb / linked |
| CTPDB_P058191_ACT_thpdb_0008 | Clinical / Approved Drug | General Therapeutic | Not available in the current structured import | Unknown | Not reported by source | Th1214_10851_rec0thpdb / unavailable |
Provenance
Source database records (3)
Citation trail
Literature (1 records)
MUC7 20-Mer: investigation of antimicrobial activity, secondary structure, and possible mechanism of antifungal action.
Bobek LA, Situ H
Audit surface
Raw annotations and release metadata
Integrated record last updated: 2026-04-15T00:59:17.814455+00:00
Modification summary
No structured modification annotations are available for this record.
Source metadata
[
{
"source_db": "dbaasp",
"organism_name": "Unknown"
},
{
"source_db": "satpdb",
"organism_name": "Unknown"
},
{
"source_db": "thpdb",
"organism_name": "Unknown"
}
]Structure metadata
{
"source_db": "satpdb",
"dssp_states": "CHHHHHTTTTCCHHHHGGGCC"
}