Record tools

Copy identifiers or export this single peptide record for a local research note.

PEPDIA-INT-056024

Gold

PolyP 4

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

VHLPPP

Indexed sequence6 aa

1VHLPPP

Length

Molecular weight

658.80 Da

Formula

C32H50N8O7

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic2

Membrane affinity proxy

Polar0

Solubility proxy

Charged1

Net charge proxy +1

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

658.7888 Da

Molecular formula

C32H50N8O7

Theoretical pI

6.7111

Net charge at pH 7

-0.1788

GRAVY

Instability index

104.6333

Aromaticity

Topological polar surface area

211.13 Å²

cLogP

0.0088

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

VHLPPP

HELM 2.0

validated simple linear

PEPTIDE1{V.H.L.P.P.P}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(Cc1c[nH]cn1)NC(=O)C(N)C(C)C)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)N1CCCC1C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-056024,
  title = {PolyP 4},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-056024},
  note = {Accessed from local PepDiana development build}
}

APA-style note

PolyP 4. (2026). PepDiana record PEPDIA-INT-056024. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-056024

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (10 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P056024_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	200.0 µM	Unknown	Not reported by source	2465ahtpdb / linked
CTPDB_P056024_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	200.0 µM	Unknown	Not reported by source	5392ahtpdb / linked
CTPDB_P056024_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	200.0 µM	Unknown	Cushman and Cheung (1971)	5755ahtpdb / linked
CTPDB_P056024_ACT_ahtpdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	200.0 µM	Unknown	Not reported by source	6445ahtpdb / linked
CTPDB_P056024_ACT_cppsite_0004	Cell-Penetrating	CPP	Not available in the current structured import	Unknown	Not reported by source	1512cppsite / linked
CTPDB_P056024_ACT_dramp_0005	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP34639dramp / linked
CTPDB_P056024_ACT_dramp_0006	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP34639dramp / linked
CTPDB_P056024_ACT_plantpepdb_0007	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	PPepDB_205plantpepdb / linked
CTPDB_P056024_ACT_satpdb_0008	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb23212satpdb / linked
CTPDB_P056024_ACT_satpdb_0009	Cell-Penetrating	Drug Delivery	Not available in the current structured import	Unknown	Not reported by source	satpdb23519satpdb / linked

Provenance

Source database records (9)

ahtpdb

2465

Raw sequence

VHLPPP

ahtpdb

6445

Raw sequence

VHLPPP

ahtpdb

5392

Raw sequence

VHLPPP

ahtpdb

5755

Raw sequence

VHLPPP

cppsite

1512

Raw sequence

VHLPPP

dramp

DRAMP34639

Raw sequence

VHLPPP

plantpepdb

PPepDB_205

Raw sequence

VHLPPP

satpdb

satpdb23212

Raw sequence

VHLPPP

satpdb

satpdb23519

Raw sequence

VHLPPP

Citation trail

Literature (4 records)

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

Angiotensin I-converting enzyme inhibitory activities of synthetic peptides related to the tandem repeated sequence of a maize endosperm protein.

Susumu MARUYAMA

Agricultural and Biological Chemistry, ISSN:0002-1369; VOL.53; NO.4; PAGE.1077-10811989

Integration of QSAR modelling and QM/MM analysis to investigate functional food peptides with antihypertensive activity

Jin Tan et al.

Molecular Simulation Volume 39, Issue 12, 20132013

-

--PMID 15054781

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.113046+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cppsite",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSSCC"
}