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PEPDIA-INT-048486

Gold

Angiotensin I-converting enzyme inhibitor F7-1

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

KDYRL

Indexed sequence5 aa

1KDYRL

Length

Molecular weight

693.80 Da

Formula

C31H51N9O9

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic2

Membrane affinity proxy

Polar0

Solubility proxy

Charged3

Net charge proxy +1

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

693.7915 Da

Molecular formula

C31H51N9O9

Theoretical pI

8.5898

Net charge at pH 7

0.7592

GRAVY

-1.88

Instability index

-25.82

Aromaticity

0.2

Topological polar surface area

325.17 Å²

cLogP

-1.8011

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

KDYRL

HELM 2.0

validated simple linear

PEPTIDE1{K.D.Y.R.L}$$$$V2.0

Canonical SMILES

validated

CC(C)CC(NC(=O)C(CCCNC(=N)N)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CC(=O)O)NC(=O)C(N)CCCCN)C(=O)O

Isomeric SMILES

validated

CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-048486,
  title = {Angiotensin I-converting enzyme inhibitor F7-1},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-048486},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Angiotensin I-converting enzyme inhibitor F7-1. (2026). PepDiana record PEPDIA-INT-048486. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-048486

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (8 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P048486_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	26.5 µM	Unknown	Extraction-free spectrophotometric assay	1261ahtpdb / linked
CTPDB_P048486_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	26.5 µM	Unknown	Li G-H et al. 2005	1824ahtpdb / linked
CTPDB_P048486_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	26.5 µM	Unknown	Modified Lieberman’s method	2695ahtpdb / linked
CTPDB_P048486_ACT_ahtpdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	26.5 µM	Unknown	Not reported by source	5326ahtpdb / linked
CTPDB_P048486_ACT_ahtpdb_0004	Metabolic/Cardiovascular	ACE Inhibitor	26.5 µM	Unknown	Li et al (2005)	6095ahtpdb / linked
CTPDB_P048486_ACT_plantpepdb_0005	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	PPepDB_3828plantpepdb / linked
CTPDB_P048486_ACT_plantpepdb_0006	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	PPepDB_3828plantpepdb / linked
CTPDB_P048486_ACT_satpdb_0007	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb16599satpdb / linked

Provenance

Source database records (7)

ahtpdb

2695

Raw sequence

KDYRL

ahtpdb

1261

Raw sequence

KDYRL

ahtpdb

1824

Raw sequence

KDYRL

ahtpdb

6095

Raw sequence

KDYRL

ahtpdb

5326

Raw sequence

KDYRL

plantpepdb

PPepDB_3828

Raw sequence

KDYRL

satpdb

satpdb16599

Raw sequence

KDYRL

Citation trail

Literature (6 records)

ISOLATION AND CHARACTERIZATION OF PEPTIDES WITH ANTIHYPERTENSIVE ACTIVITY IN FOODSTUFFS.

Puchalska P1, Alegre ML, López MC.

Crit Rev Food Sci Nutr. 2013 Sep 2.2013PMID 24915368

Antihypertensive Properties of Plant Protein Derived Peptides

Anne Pihlanto and Sari Ma?kinen

Bioactive Food Peptides in Health and Disease Edited by Blanca Hernandez-Ledesma and Chia-Chien Hsieh, ISBN 978-953-51-0964-8, 276 pages2013

Vegetable foods: A cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities.

M C García, P Puchalska, C Esteve, M L Marina

Talanta 03/2013; 106C:328-349.2013PMID 23598136

Novel angiotensin I-converting enzyme inhibitory peptides isolated from Alcalase hydrolysate of mung bean protein

Li, G. H. et al.,

Pept Sci 12 p.509-142006PMID 16680798

Integration of QSAR modelling and QM/MM analysis to investigate functional food peptides with antihypertensive activity

Jin Tan et al.

Molecular Simulation Volume 39, Issue 12, 20132013

-

--PMID 24547749

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.113046+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "plantpepdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCCC"
}