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PEPDIA-INT-047410

Silver

Omiganan IP-12

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

IRLRWRWKWPWP

Indexed sequence12 aa

1IRLRWRWKWPWP

Length

Molecular weight

1780.17 Da

Formula

C90H126N26O13

Structure type

Synthesis

Synthetic

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic6

Membrane affinity proxy

Polar0

Solubility proxy

Charged4

Net charge proxy +4

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1780.1299 Da

Molecular formula

C90H126N26O13

Theoretical pI

Net charge at pH 7

3.7591

GRAVY

-1.325

Instability index

118.2833

Aromaticity

0.3333

Topological polar surface area

640.72 Å²

cLogP

1.6505

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

IRLRWRWKWPWP

HELM 2.0

validated simple linear

PEPTIDE1{I.R.L.R.W.R.W.K.W.P.W.P}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N1CCCC1C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N1CCCC1C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-047410,
  title = {Omiganan IP-12},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-047410},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Omiganan IP-12. (2026). PepDiana record PEPDIA-INT-047410. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-047410

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (8 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P047410_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP04872apd / linked
CTPDB_P047410_ACT_apd_0001	Bioregulatory	Chemotactic	Not available in the current structured import	Unknown	Not reported by source	AP04872apd / linked
CTPDB_P047410_ACT_dbaasp_0002	Antimicrobial	-	4 µg/ml	Staphylococcus warneri	Not reported by source	DBAASPS_22910_chain0dbaasp / linked
CTPDB_P047410_ACT_dbaasp_0003	Antimicrobial	-	4 µg/ml	Staphylococcus epidermidis	Not reported by source	DBAASPS_22910_chain0dbaasp / linked
CTPDB_P047410_ACT_dbaasp_0004	Antimicrobial	-	16 µg/ml	Enterococcus faecalis	Not reported by source	DBAASPS_22910_chain0dbaasp / linked
CTPDB_P047410_ACT_dbaasp_0005	Antimicrobial	-	8 µg/ml	Acinetobacter baumannii	Not reported by source	DBAASPS_22910_chain0dbaasp / linked
CTPDB_P047410_ACT_dbaasp_0006	Antimicrobial	-	8 µg/ml	Klebsiella pneumoniae	Not reported by source	DBAASPS_22910_chain0dbaasp / linked
CTPDB_P047410_ACT_dbaasp_0007	Antimicrobial	-	32 µg/ml	Pseudomonas aeruginosa	Not reported by source	DBAASPS_22910_chain0dbaasp / linked

Provenance

Source database records (2)

apd

AP04872

Raw sequence

IRLRWRWKWPWP

dbaasp

DBAASPS_22910_chain0

Raw sequence

IRLRWRWKWPWP

Citation trail

Literature (1 records)

Omiganan-Based Synthetic Antimicrobial Peptides for the Healthcare of Infectious Endophthalmitis.

Wang S, Ong ZY, Qu S, Wang Y, Xin J, Zheng Z, Wu H. 2024

ACS Biomater Sci Eng2024PMID 39449570

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:12.810082+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µg/ml",
      "value": "100",
      "source_db": "dbaasp",
      "assay_method": "0% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Rabbit erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": ">2000",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Rabbit erythrocytes"
    },
    {
      "source_db": "dbaasp",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human umbilical vein endothelial cells HUVEC"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  }
]