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PEPDIA-INT-047244

Gold

Myxinidin

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

GIHDILKYGKPS

Indexed sequence12 aa

1GIHDILKYGKPS

Length

Molecular weight

1327.55 Da

Formula

C61H98N16O17

Structure type

Linear

Synthesis

Ribosomal

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic4

Membrane affinity proxy

Polar1

Solubility proxy

Charged4

Net charge proxy +2

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1327.5277 Da

Molecular formula

C61H98N16O17

Theoretical pI

8.505

Net charge at pH 7

0.8454

GRAVY

-0.5167

Instability index

16.9667

Aromaticity

0.0833

Topological polar surface area

533.11 Å²

cLogP

-3.7225

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

GIHDILKYGKPS

HELM 2.0

validated simple linear

PEPTIDE1{G.I.H.D.I.L.K.Y.G.K.P.S}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)CN)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CC(=O)O)C(=O)NC(C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(Cc1ccc(O)cc1)C(=O)NCC(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CO)C(=O)O)C(C)CC

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)CC

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-047244,
  title = {Myxinidin},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-047244},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Myxinidin. (2026). PepDiana record PEPDIA-INT-047244. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-047244

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (49 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P047244_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP01578apd / linked
CTPDB_P047244_ACT_apd_0001	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP01578apd / linked
CTPDB_P047244_ACT_apd_0003	Antimicrobial	Anti-Biofilm	Not available in the current structured import	Unknown	Not reported by source	AP01578apd / linked
CTPDB_P047244_ACT_apd_0004	Wound Healing	Wound Healing	Not available in the current structured import	Unknown	Not reported by source	AP01578apd / linked
CTPDB_P047244_ACT_camp_0005	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3348camp / linked
CTPDB_P047244_ACT_camp_0006	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3348camp / linked
CTPDB_P047244_ACT_camp_0007	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3348camp / linked
CTPDB_P047244_ACT_dbaasp_0008	Antimicrobial	-	2.0 µg/ml	Escherichia coli D31	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0009	Antimicrobial	-	2.5 µg/ml	Salmonella typhimurium C610	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0010	Antimicrobial	-	8.5 µg/ml	Staphylococcus epidermidis C621	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0011	Antimicrobial	-	7.0 µg/ml	Pseudomonas aeruginosa Z61	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0012	Antimicrobial	-	10.0 µg/ml	Pseudomonas aeruginosa K799	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0013	Antimicrobial	-	10.0 µg/ml	Candida albicans C627	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0014	Antimicrobial	-	2.0 µg/ml	Aeromonas salmonicida subsp. salmonicida A449	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0015	Antimicrobial	-	1.0 µg/ml	Vibrio anguillarum 02-11	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0016	Antimicrobial	-	2.0 µg/ml	Yersinia ruckeri 96-4	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0017	Antimicrobial	-	NA	Escherichia coli D31	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0018	Antimicrobial	-	>32 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0019	Antimicrobial	-	>32 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0020	Antimicrobial	-	>32 µM	Salmonella typhimurium KCTC 1926	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0021	Antimicrobial	-	>32 µM	Salmonella typhimurium KCTC 1926	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0022	Antimicrobial	-	>32 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0023	Antimicrobial	-	>32 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0024	Antimicrobial	-	>32 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0025	Antimicrobial	-	>32 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0026	Antimicrobial	-	>32 µM	Listeria monocytogenes KCTC 3710	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0027	Antimicrobial	-	>32 µM	Escherichia coli CCARM 1229	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0028	Antimicrobial	-	>32 µM	Escherichia coli CCARM 1238	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0029	Antimicrobial	-	>32 µM	Salmonella typhimurium CCARM 8009	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0030	Antimicrobial	-	>32 µM	Salmonella typhimurium CCARM 8013	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0031	Antimicrobial	-	>32 µM	Staphylococcus aureus CCARM 3114	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0032	Antimicrobial	-	>32 µM	Staphylococcus aureus CCARM 3709	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0033	Antimicrobial	-	>32 µM	Pseudomonas aeruginosa 3592	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0034	Antimicrobial	-	>32 µM	Pseudomonas aeruginosa 5018	Not reported by source	DBAASPS_3389_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0035	Antimicrobial	-	5 µM	Escherichia coli ATCC 11219	Not reported by source	DBAASPS_6810_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0036	Antimicrobial	-	30 µM	Pseudomonas aeruginosa ATCC 13388	Not reported by source	DBAASPS_6810_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0037	Antimicrobial	-	20 µM	Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028	Not reported by source	DBAASPS_6810_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0038	Antimicrobial	-	10 µM	Klebsiella pneumoniae ATCC 10031	Not reported by source	DBAASPS_6810_chain0dbaasp / linked
CTPDB_P047244_ACT_dbaasp_0039	Antimicrobial	-	10 µM	Staphylococcus aureus ATCC 6538	Not reported by source	DBAASPS_6810_chain0dbaasp / linked
CTPDB_P047244_ACT_dramp_0040	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP04532dramp / linked
CTPDB_P047244_ACT_dramp_0041	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP04532dramp / linked
CTPDB_P047244_ACT_dramp_0042	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP04532dramp / linked
CTPDB_P047244_ACT_dramp_0043	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP04532dramp / linked
CTPDB_P047244_ACT_dramp_0044	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP29542dramp / linked
CTPDB_P047244_ACT_hemolytik_0045	Toxicity	Hemolytic	500.0 µg/ml	Erythrocytes	Not reported by source	1290hemolytik / linked
CTPDB_P047244_ACT_satpdb_0046	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb19051satpdb / linked
CTPDB_P047244_ACT_satpdb_0047	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb19051satpdb / linked
CTPDB_P047244_ACT_satpdb_0048	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb19051satpdb / linked
CTPDB_P047244_ACT_satpdb_0049	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb19051satpdb / linked

Provenance

Source database records (8)

apd

AP01578

Raw sequence

GIHDILKYGKPS

camp

CAMPSQ3348

Raw sequence

GIHDILKYGKPS

dbaasp

DBAASPS_3389_chain0

Raw sequence

GIHDILKYGKPS

dbaasp

DBAASPS_6810_chain0

Raw sequence

GIHDILKYGKPS

dramp

DRAMP04532

Raw sequence

GIHDILKYGKPS

dramp

DRAMP29542

Raw sequence

GIHDILKYGKPS

hemolytik

1290

Raw sequence

GIHDILKYGKPS

satpdb

satpdb19051

Raw sequence

GIHDILKYGKPS

Citation trail

Literature (4 records)

Myxinidin, a novel antimicrobial peptide from the epidermal mucus of hagfish, Myxine glutinosa L.

Subramanian S, Ross NW, MacKinnon SL.2009

Mar Biotechnol (NY)2009PMID 38204197

-

--PMID 19330556

Myxinidin, a novel antimicrobial peptide from the epidermal mucus of hagfish, Myxine glutinosa L.

Subramanian S, Ross NW, MacKinnon SL

Mar Biotechnol2009PMID 26450121

Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish.

Cantisani M, Leone M, Mignogna E, Kampanaraki K, Falanga A, Morelli G, Galdiero M, Galdiero S

Antimicrob Agents Chemother2013PMID 24002100

IP evidence

Patents (1)

WO 2017048028

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.604459+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Rabbit erythrocytes"
    },
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "100",
      "source_db": "dbaasp",
      "assay_method": "1% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "200",
      "source_db": "dbaasp",
      "assay_method": "5% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Vero cells"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.19330556] Non-hemolytic activity against rabbit red blood cells at concentrations 50-fold higher than its antimicrobial activity.",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCGGGCCSSSCC"
}