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PEPDIA-INT-044741

Gold

Unnamed peptide

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

TKVIP

Indexed sequence5 aa

1TKVIP

Length

Molecular weight

556.71 Da

Formula

C26H48N6O7

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic2

Membrane affinity proxy

Polar1

Solubility proxy

Charged1

Net charge proxy +1

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

556.6953 Da

Molecular formula

C26H48N6O7

Theoretical pI

8.4101

Net charge at pH 7

0.3972

GRAVY

0.5

Instability index

-14.74

Aromaticity

Topological polar surface area

217.18 Å²

cLogP

-0.9444

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

TKVIP

HELM 2.0

validated simple linear

PEPTIDE1{T.K.V.I.P}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)C(C)O)C(C)C)C(=O)N1CCCC1C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)[C@@H](C)O)C(C)C)C(=O)N1CCC[C@H]1C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

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Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-044741,
  title = {Unnamed peptide},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-044741},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Unnamed peptide. (2026). PepDiana record PEPDIA-INT-044741. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-044741

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (9 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P044741_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	400.0 µM	Unknown	Cushman and Cheung (1971)	1724ahtpdb / linked
CTPDB_P044741_ACT_ahtpdb_0002	Metabolic/Cardiovascular	ACE Inhibitor	400.0 µM	Unknown	Not reported by source	2488ahtpdb / linked
CTPDB_P044741_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Cushman and Cheung (1971)	4165ahtpdb / linked
CTPDB_P044741_ACT_ahtpdb_0003	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Cushman and Cheung (1971)	5001ahtpdb / linked
CTPDB_P044741_ACT_ahtpdb_0004	Metabolic/Cardiovascular	ACE Inhibitor	400.0 µM	Unknown	Not reported by source	6496ahtpdb / linked
CTPDB_P044741_ACT_fermfoodb_0005	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	LC-ESI-MS/MS.	FermFooDB_Casein_FMDB319fermfoodb / linked
CTPDB_P044741_ACT_fermfoodb_0006	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	LC-ESI-MS/MS.	FermFooDB_Casein_FMDB320fermfoodb / linked
CTPDB_P044741_ACT_fermfoodb_0007	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	LC-ESI-MS/MS.	FermFooDB_Casein_FMDB321fermfoodb / linked
CTPDB_P044741_ACT_satpdb_0008	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb25097satpdb / linked

Provenance

Source database records (9)

ahtpdb

4165

Raw sequence

TKVIP

ahtpdb

2488

Raw sequence

TKVIP

ahtpdb

1724

Raw sequence

TKVIP

ahtpdb

6496

Raw sequence

TKVIP

ahtpdb

5001

Raw sequence

TKVIP

fermfoodb

FermFooDB_Casein_FMDB319

Raw sequence

TKVIP

fermfoodb

FermFooDB_Casein_FMDB320

Raw sequence

TKVIP

fermfoodb

FermFooDB_Casein_FMDB321

Raw sequence

TKVIP

satpdb

satpdb25097

Raw sequence

TKVIP

Citation trail

Literature (7 records)

Antihypertensive peptides from food proteins: a review.

Martínez-Maqueda D1, Miralles B, Recio I, Hernández-Ledesma B.

Food Funct. 2012 Apr;3(4):350-61.2012PMID 22249830

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

Antihypertensive peptides: production, bioavailability and incorporation into foods.

Hernández-Ledesma B1, del Mar Contreras M, Recio I.

Adv Colloid Interface Sci. 2011 Jun 9;165(1):23-352011PMID 21185549

Identification of two distinct antibacterial domains within the sequence of bovine alpha(s2)-casein.

Recio I1, Visser S

Biochim Biophys Acta. 1999 Aug 5;1428(2-3):314-26.1999PMID 10434050

Is the structural diversity of tripeptides sufficient for developing functional food additives with satisfactory multiple bioactivities?

Jian-Hui Wang et al.,

Journal of Molecular Structure 1040 (2013) 164-1702013

-

--PMID 22103626

-

--PMID 8880454

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:10.991164+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "fermfoodb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCCC"
}