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PEPDIA-INT-044476

Gold

Human calcitonin

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP

Indexed sequence32 aa

1CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP

Length

Molecular weight

3420.91 Da

Formula

C151H227N39O46S3

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic11

Membrane affinity proxy

Polar12

Solubility proxy

Charged3

Net charge proxy +1

Aromatic5

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

3420.8463 Da

Molecular formula

C151H227N39O46S3

Theoretical pI

6.7248

Net charge at pH 7

-0.1734

GRAVY

0.0063

Instability index

34.8719

Aromaticity

0.125

Topological polar surface area

1353.81 Å²

cLogP

-16.1641

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

105

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP

HELM 2.0

validated simple linear

PEPTIDE1{C.G.N.L.S.T.C.M.L.G.T.Y.T.Q.D.F.N.K.F.H.T.F.P.Q.T.A.I.G.V.G.A.P}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(Cc1c[nH]cn1)NC(=O)C(Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(Cc1ccccc1)NC(=O)C(CC(=O)O)NC(=O)C(CCC(N)=O)NC(=O)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CCSC)NC(=O)C(CS)NC(=O)C(NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CC(N)=O)NC(=O)CNC(=O)C(N)CS)C(C)O)C(C)O)C(C)O)C(C)O)C(C)O)C(=O)NCC(=O)NC(C(=O)NCC(=O)NC(C)C(=O)N1CCCC1C(=O)O)C(C)C

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CS)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-044476,
  title = {Human calcitonin},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-044476},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Human calcitonin. (2026). PepDiana record PEPDIA-INT-044476. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-044476

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (4 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P044476_ACT_satpdb_0000	Bioregulatory	Cell-Cell Communication	Not available in the current structured import	Unknown	Not reported by source	satpdb26020satpdb / linked
CTPDB_P044476_ACT_thpdb_0001	Clinical / Approved Drug	General Therapeutic	Not available in the current structured import	Unknown	Not reported by source	Th1184_10793_rec0thpdb / unavailable
CTPDB_P044476_ACT_topicalpdb_0002	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	6.20 (cm/sec) * 10 8; permeability coefficient for transdermal iontophoretic transport of peptide/ protein drugs from polyacrylamide hydrogels was measured.; in vitro	1644topicalpdb / linked
CTPDB_P044476_ACT_topicalpdb_0003	Wound Healing	Skin Penetrating	Not available in the current structured import	Unknown	1.95(cm/sec) * 10 8; permeability coefficient for transdermal iontophoretic transport of peptide/ protein drugs from p-HEMA hydrogels was measured.; in vitro	1647topicalpdb / linked

Provenance

Source database records (4)

Source-specific sequence or modification context. One or more source records use a sequence notation that differs from the canonical backbone. Open each raw sequence before interpreting stereochemistry, terminal groups, or non-standard residues.

satpdb

satpdb26020

Raw sequence

CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP

thpdb

Th1184_10793_rec0

Raw sequence

CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP

topicalpdb

1644

Raw sequence

CGNLSTCMLGTYTQ DFNKFHTFPQTAIGVGAP

topicalpdb

1647

Raw sequence

CGNLSTCMLGTYTQ DFNKFHTFPQTAIGVGAP

Citation trail

Literature (1 records)

-

--PMID 8321834

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:21.983112+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "thpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "topicalpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSHHHHHHHHHHHHHHHHHHCTTTTTCCSCC"
}